Study on the dissolution of four effective components in Paracetamol,Aminophenazone Phenacetin,Caffeine and Chlorphenamine Maleate Granules
GUO Li-rong XU Song WU Yin-shuang LI Na
Yunnan Institute of Materia Medica,Yunnan Baiyao Group Innovation and R &D Center,Yunnan Province Company Key Laboratory for Traditional Chinese Medicine and Ethnic Drug of New Drug Creation,Kunming 650111,China
Abstract：Objective To establish a method for the dissolution of four effective components in Paracetamol,Aminophenazone Phenacetin,Caffeine and Chlorphenamine Maleate Granules.Methods The paddle method was adopted,the rotation rate was 50 r/min,and the volume of dissolution mediums was 900 ml.Hydrochloric acid solution (0.1N),phosphate buffer (pH=6.8),water and acetic acid-sodium acetate buffer solution (pH=4.0) were adopted as dissolution mediums.Results The dissolution of Caffeine,Paracetamol,Chlorpheniramine Maleate and Aminopyrine were all above 85% of the labelled quantity in 1 h.Conclusion The study provides the experimental basis for the consistency evaluation of the dissolution curves of Paracetamol,Aminophenazone Phenacetin,Caffeine and Chlorphenamine Maleate Granules in vitro.
郭丽蓉； 徐松； 吴银双； 李娜. 酚氨咖敏颗粒中四种有效成分的溶出研究[J]. 中国当代医药, 2020, 27(14): 15-20.
GUO Li-rong； XU Song； WU Yin-shuang； LI Na. Study on the dissolution of four effective components in Paracetamol,Aminophenazone Phenacetin,Caffeine and Chlorphenamine Maleate Granules. 中国当代医药, 2020, 27(14): 15-20.
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