Abstract：Objective To investigate the risk factors of secondary malignant glaucoma after trabeculectomy in patients with primary angle-closure glaucoma (PACG) in order to guide clinical practice.Methods The clinical data of 140 cases of patients with PACG (120 eyes) treated in the ophthalmology department of our hospital from June 2017 to December 2018 were retrospectively analyzed.According to whether secondary malignant glaucoma occurred,the patients were divided into observation group (n=60,60 eyes with secondary malignant glaucoma) and control group (n=80,60 eyes without secondary malignant glaucoma).The relevant data of the two groups of patients were compared,and the factors that might lead to secondary malignant glaucoma were recorded and analyzed.Results There were significant differences in age,axial length,lens thickness,preoperative intraocular pressure,anterior chamber depth and angle structure between the two groups (P<0.05).There were no significant differences in gender,education level,family income per capita,hypertension,diabetes mellitus and coronary heart disease between the two groups (P>0.05).Logistic regression analysis showed that age ≤60 years,high preoperative intraocular pressure,angle closed completely,axial length <22 mm,lens thickness <4.5 mm,and anterior chamber depth ＜2 mm were all risk factors for secondary malignant glaucoma after PACG trabeculectomy (OR>1,P<0.05).Conclusion Age,preoperative intraocular pressure,anterior chamber angle structure,axial length,lens thickness and anterior chamber depth all increase the risk of malignant glaucoma in patients with PACG.For patients with such risk factors,preoperative symptomatic treatment should be actively taken to reduce the risk of malignant glaucoma in patients after surgery and improve the prognosis of patients.
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