Abstract：Objective To observe the preventive and therapeutic effects of compound Chinese medicine components on diabetes mellitus (DM), and to explore its prevention and treatment mechanism.Methods The rat model of DM was induced by intraperitoneal injection of streptozotocin administered at a dose of 55 mg/kg.After a successful modeling, a total of 40 rats were randomly assigned into the blank control group, the model control group and the drug intervention group (the high-dose drug intervention group, the low-dose drug intervention group), 10 cases in each group.The drug intervention group was treated with high- and low-dose of compound Chinese medicine components, the blank control group and the model control group were intragastrically administered with normal saline per day according to the weight standard of 10 ml/kg.The levels of fasting blood glucose (FBG), glucose tolerance, superoxide dismutase (SOD) activity and malondialdehyde (MDA) in pancreas were observed.Results The level of blood glucose of the model control group was significantly higher than that of the blank control group (P＜0.001).The levels of blood glucose at 0.0, 0.5, 1.0, 2.0 h of the drug intervention group were significantly lower than those of the model control group (P＜0.05).The levels of glucose tolerance of the model control group were significantly lower than those of the blank control group, the levels of glucose tolerance for some time of the compound Chinese medicine component intervention group in a large dose administration were significantly higher than those of the model control group.The level of SOD of the model control group was significantly lower than that of the blank control group, and the MDA of the model control group was higher than that of the blank control group, the level of SOD of the high-dose intervention group was significantly higher than that of the model control group, the level of MDA of the high-dose drug intervention group was greatly lower than that of the model control group (P＜0.01).The level of SOD of the low-dose drug intervention group was higher than that of the model control group, with statistical difference (P＜0.05).The MDA in the low-dose drug intervention group was much lower than that in the model control group, with statistical significance (P＜0.01).Conclusion Compound Chinese herbal medicines have preventive and therapeutic effects on diabetes mellitus.
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