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摘要目的探讨补肾健脾益气方治疗脾肾气虚型慢性肾脏病3 期的临床效果。方法选取2016年3月～2017年12月湖北省中医院收治的100 例脾肾气虚型慢性肾脏病3 期患者作为研究对象，按照随机数字表法将其分为对照组（50 例）与试验组（50 例）。对照组患者采用西医基础治疗，试验组患者在对照组的基础上加用补肾健脾益气方。比较两组患者治疗前后的血肌酐（SCr）、血尿素氮（BUN）、尿素（UA）、肾小球滤过率（eGFR）、尿蛋白（U-Pro）指标、治疗效果及不良反应发生情况。结果两组患者治疗前的SCr、BUN、UA、eGFR、U-Pro 比较，差异无统计学意义（P＞0.05）；试验组患者治疗12 周后的SCr、BUN、UA、U-Pro 水平均低于治疗前，eGFR 高于治疗前，差异有统计学意义（P＜0.01）；对照组患者治疗12 周后的SCr、UA 水平均低于治疗前，差异有统计学意义（P＜0.05）；对照组患者治疗前与治疗12 周后的BUN、eGFR、U-Pro 比较，差异无统计学意义（P＞0.05）；试验组患者治疗12 周后的SCr、UA、U-Pro 水平均低于对照组，eGFR 高于对照组，差异有统计学意义（P＜0.05）；两组患者治疗12 周后的BUN 水平比较，差异无统计学意义（P＞0.05）。试验组患者的治疗总有效率为72.92%，明显高于对照组的46.81%，差异有统计学意义（P＜0.05）。疗程结束后两组患者均未出现明显的不良反应。结论采用补肾健脾益气方治疗慢性肾脏病3 期脾肾气虚型患者，在改善中医症候、减少尿蛋白、保护肾功能方面均有良好的临床效果。

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	田曼
	祁正亮
	李姣

关键词 ：补肾健脾益气方, 慢性肾脏病3 期, 脾肾气虚, 随机对照研究

Abstract：Objective To explore the clinical effect of Bushen Jianpi Yiqi Recipe in the treatment of stage 3 chronic kidney disease with spleen and kidney qi deficiency type.Methods One hundred patients with stage 3 chronic kidney disease of spleen and kidney qi deficiency who were admitted to Hubei Provincial Hospital of Traditional Chinese Medicine from March 2016 to December 2017 were selected as the study subjects.They were divided into control group (50 cases) and experimental group (50 cases) according to the random number table method.The patients in the control group were treated with Western medicine, and the patients in the experimental group were treated with Bushen Jianpi Yiqi Recipe on the basis of the control group.The serum creatinine (SCr), blood urea nitrogen (BUN), urea (UA),glomerular filtration rate (eGFR) and urine protein (U-Pro) index before and after treatment, the treatment effect and adverse reactions were compared between the two groups.Results There were no significant differences in SCr, BUN,UA, eGFR and U-Pro between the two groups before treatment (P＞0.05).The levels of SCr, BUN, UA and U-Pro in the experimental group after 12 weeks of treatment were lower than those before treatment, the eGFR was higher than that before treatment, and the differences were statistically significant (P＜0.01).The levels of SCr and UA in the control group after 12 weeks of treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05).There were no significant differences in BUN, eGFR and U-Pro between the control group before treatment and after 12 weeks of treatment (P＞0.05).The levels of SCr, UA and U-Pro in the experimental group after 12 weeks of treatment were lower than those in the control group, the eGFR was higher than that in the control group, and the differences were statistically significant (P＜0.05).There was no significant difference in BUN level between the two groups after 12 weeks of treatment (P＞0.05).The total effective rate of the treatment in the experimental group was 72.92%, which was significantly higher than that in the control group (46.81%), and the difference was statistically significant (P＜0.05).There were no significant adverse reactions in the two groups after the end of the treatment.Conclusion Bushen Jianpi Yiqi Recipe in the treatment of patients with stage 3 chronic kidney disease of spleen and kidney qi deficiency has good clinical effect in improving traditional Chinese medicine symptoms, reducing urine protein and protecting kidney function.

Key words： Bushen Jianpi Yiqi Recipe Stage 3 chronic kidney disease Spleen and kidney qi deficiency Randomized controlled study

基金资助:中国中医科学院中医基础理论研究所基本科研业务费自主选题项目（YZ-1755）

引用本文:

田曼；祁正亮；李姣.

补肾健脾益气方治疗脾肾气虚型慢性肾脏病3 期的临床效果

[J]. 中国当代医药, 2019, 26(12): 12-15转25.
TIAN Man；QI Zheng-liang；LI Jiao. Clinical effect of Bushen Jianpi Yiqi Recipe in the treatment of stage 3 chronic kidney disease with spleen and kidney qi deficiency type. 中国当代医药, 2019, 26(12): 12-15转25.

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