克罗恩病伴肛周病变的临床特征及相关因素分析

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摘要目的探讨克罗恩病伴肛周病变的临床特点及肛周病变的相关影响因素。方法回顾性分析安徽省立医院（即安徽医科大学附属省立医院）消化内科2013年1月～2017年12月的90 例克罗恩病住院患者的临床资料，依据是否合并肛周病变将其分为肛周病变组（63 例）与未合并肛周病变组（27 例）。对肛周病变组患者的住院资料进行临床分析，并与未合并肛周病变组进行对比研究，将两组患者的各项指标[性别、年龄、吸烟史、发病部位、疾病类型、营养情况、克罗恩病疾病活动指数（CDAI）等]纳入统计学分析，分析克罗恩病肛周病变的相关影响因素。结果两组患者的性别、年龄、营养情况、CDAI 评分等比较，差异无统计学意义（P＞0.05）。两组患者的抽烟、发病部位、疾病类型方面比较，差异有统计学意义（P＜0.05）。其中抽烟和发病部位是克罗恩病肛周病变的独立危险因素（P＜0.05）。结论抽烟和发病部位是克罗恩病肛周病变发生的重要影响因素，予以更为积极的干预，以提高患者的生活质量。

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	李浩
	王巧民
	李鸣涛
	朱林林

关键词 ：克罗恩病, 肛周病变, 临床特点, 影响因素

Abstract：Objective To explore the clinical characteristics of perianal Crohn′s disease and the related factors of perianal lesions. Methods The clinical data of 90 patients with Crohn′s disease hospitalized in the Department of Gastroenterology of Anhui Provincial Hospital (Affiliated Provincial Hospital of Anhui Medical University) from January 2013 to December 2017 were retrospectively analyzed. The patients were divided into the perianal lesions group (63 cases) and the non-perianal lesions group (27 cases) according to whether there were perianal lesions or not. The clinical data of patients with perianal lesions were analyzed and compared with those and without perianal lesions, and the indexes such as sex, age, smoking history, location of disease, disease type, nutritional status, Crohn′s disease activity index (CDAI) score of the two groups were included in statistical analysis to analyze the related factors of perianal lesions. Results There were no significant differences in gender, age, nutrition status, CDAI score between the two groups(P＞0.05), but there were significant differences in smoking, location of disease and type of disease between the two groups (P＜0.05). Smoking and location were independent risk factors for perianal lesions of Crohn′s disease (P＜0.05).Conclusion Smoking and the location of disease are important factors affecting the occurrence of perianal lesions in Crohn′s disease. More active intervention will lead to a greater improvement in the quality of life of patients.

Key words： Crohn&prime s disease； Perianal lesions； Clinical feature； Influencing factors

引用本文:

李浩；王巧民；李鸣涛；朱林林. 克罗恩病伴肛周病变的临床特征及相关因素分析[J]. 中国当代医药, 2019, 26(9): 57-60.
LI Hao；WANG Qiao-min； LI Ming-tao；ZHU Lin-lin. Clinical characteristics and related factors analysis of Crohn′s disease with perianal lesions. 中国当代医药, 2019, 26(9): 57-60.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2019/V26/I9/57

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