Changes of renal tubular related indexes in IgA nephropathy combined with hyperuricemia
LIU Ye-wei1 SUN Ming1 SUN Yi-jun1 WU Wen-bin2▲
1.Clinical College of Weifang Medical University in Shandong Province,Weifang 261053,China;
2.Department of Nephrology,Yidu Central Hospital of Weifang City in Shandong Province,Weifang 262500,China.
Abstract:Objective To investigate the changes of renal tubular related index in patients with hyperuricemia IgA nephropathy,and understand the impact of high uric acid on renal tubules.Methods A total of 105 patients with primary IgA nephropathy treated in Yidu Central Hospital of Weifang from February 2014 to January 2016 were selected as the subjects,and divided into normal uric acid group(n=55)and hyperuricemia group(n=50).The urinary β2-microglobulin(β2-MG),N-acetyl-β-D-glucosaminidase(NAG),Retinol-binding protein(RBP),titratable acid(TA),urinary ammonium ion(NH4+),urine osmotic pressure(UOSM)were observed.Results The urinary β2-MG,RBP and NAG in high uric acid group were significantly higher than those in normal uric acid group,the difference was statistically significant(P<0.01).There was no significant difference in urine TA,NH4+and UOSM between the two groups(P>0.05).Conclusion Hyperuricemia has obvious damage to the proximal tubules of patients with IgA nephropathy,but it has little effect on the acidification and concentration and dilution of distal tubules.
刘叶伟;孙铭;孙逸君;武文斌. 伴高尿酸血症IgA肾病患者肾小管相关指标的变化[J]. 中国当代医药, 2018, 25(10): 68-70.
LIU Ye-wei;SUN Ming;SUN Yi-jun;WU Wen-bin. Changes of renal tubular related indexes in IgA nephropathy combined with hyperuricemia. 中国当代医药, 2018, 25(10): 68-70.
Moriyama T,Itabashi M,Takei T,et al.High uric acid level is a risk factor for progression of IgA nephropathy with chronic kidney disease stage G3a[J].J Nephrol,2015,28(4):451-456.
Moriyama T,Tanaka K,Iwasaki C,et al.Prognosis in IgA nephropathy:30-year analysis of 1 012 patients at a single center in Japan[J].PloS one,2014,9(3):e91756.
[5]
Zeng CH,Le W,Ni Z,et al.A multicenter application and evaluation of the oxford classification of IgA nephropathy in adult chinese patients[J].Am J Kidney Dis,2012,60(5):812-820.
Syrjonen J,Mustonen J.Hypertriglyceridaemia and hyperuricaemia are risk factors for progression of IgA nephropathy[J].Nephrol Dial Transplant,2000,15(1):34-42.