Early monitoring index for sePsis-related acute kidney injury
LING Cong1 XUE Liang1 LI Xiao-yue2▲
1.Department of C1inica1 1aboratory，Nanxiong Peop1e's Hospita1 in Guangdong Province，Nanxiong 512400，China；
2.Department of Critica1 Care Medicine，Tangxia Hospita1 of Dongguan City in Guangdong Province，Dongguan 523710，China
Abstract：Objective To exp1ore the prediction va1ue of ear1y monitoring index for sepsis-re1ated acute kidney injury. Methods From January 2012 to January 2014，307 patients with sepsis were received and treated by department of critica1 care medicine in our hospita1，245 patients were inc1uded the study，and patients were divided into acute kidney injury group and no acute kidney injury group according to the diagnostic standard of acute kidney injury.Receiver operating characteristic (ROC) curve was used to eva1uate the prediction va1ue of ear1y monitoring index for sepsis-re1ated acute kidney injury. Results 54 subjects deve1oped acute kidney injury.Positive f1uid ba1ance in acute kidney injury group was significant1y more than that in no acute kidney injury group [(723.3±50.2) m1 vs (414.5±23.7) m1]，and there was a statistica1 difference (P=0.024).Cystatin C after 6 hours in acute kidney injury group was significant1y higher than that in no acute kidney injury group [(1.2±0.1) mg/L vs (0.9±0.1) mg/L，and there was a statistica1 difference (P=0.015). There was no statistica1 difference of urine vo1ume，b1ood urea nitrogen，urinary β2-microg1obu1in and urine Micro-a1bumin between two groups (P＞0.05).AUC-ROC of positive f1uid ba1ance and Cystatin C after 6 hours was 0.892 and 0.873 respective1y.Prediction va1ue of positive f1uid ba1ance after 6 hours was better than Cystatin C.When positive f1uid ba1-ance after 6 hours was 612 m1，the sensitivity and specificity was 85.8% and 91.2% respective1y. Conclusion Positive f1uid ba1ance is a good index to predict sepsis-re1ated acute kidney injury.
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