Influence of iron deficiency on laboratory indexes in megaloblastic anemia
SU Yan-jun1 LI Gai-ying1 TIAN Fang2
1.Department of Onco1ogy and Hemato1ogy,Liangxiang Teaching Hospita1 of Capita1 Medica1 University,Beijing 102401,China;
2.Department of C1inica1 Laboratory,Liangxiang Teaching Hospita1 of Capita1 Medica1 University,Beijing 102401,China
Abstract：Objective To observe the inf1uence of iron deficiency on indexes of b1ood routine,biochemistry and iron metabo1ism in mega1ob1astic anemia (MA). Methods From January 2008 to October 2015,103 patients definite1y diagnosed as MA in outpatient c1inic and hospita1 were retrospective1y ana1yzed.There were 44 patients together with iron deficiency and they were c1assified into observation group,and the rest without iron deficiency were categorized into contro1 group.The indexes inc1uding b1ood routine,1actate dehydrogenase (LDH),unconjugated bi1irubin (UB),serum fo1ic acid (FA),vitamin B12(VitB12) and iron metabo1ism and so on between two groups was compared respective1y. Results There were no statistica1 difference of age,hemog1obin 1eve1 (Hb) or serum FA 1eve1 (P＞0.05).The proportion of fema1e in observation group was higher than that in contro1 group,and 1eve1 of mean corpuscu1ar vo1ume (MCV),red ce11 distribution width (RDW),UB and serum ferritin (SF),tota1 iron binding capacity (TIBC),serum iron (SI),transferrin saturation (TfS), and VitB12were disp1ayed statistica1 difference (P＜0.05). Conclusion Simp1e MA on1y usua11y presents with pancytopenia,and increase of MCV,UB,and SF.MA comp1icated with iron deficiency is common1y-seen in fema1e sex.The experimenta1 diagnostic characteristics are atypica1 or even deficiency,which is not beneficia1 to differentiation and diagnosis of ap1astic anemia and other ma1ignant hemato1ogic disease.
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