胰岛自身抗体和生化指标在糖尿病分型诊断中的应用价值

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摘要目的分析探讨针对糖尿病患者检测抗胰岛素抗体、抗胰岛细胞抗体、抗谷氨酸脱羧酶抗体的临床应用价值。方法选取我院2013年8月~2016年8月收治的临床DM患者230例作为研究对象,检测患者的抗胰岛素抗体、抗胰岛细胞抗体、抗谷氨酸脱羧酶抗体。根据抗体阴性/阳性分为T1DM组和T2DM组,分别比较两组的空腹葡萄糖、空腹胰岛素及空腹C肽浓度。结果 T1DM组患者的IAA-Ab、ICA-Ab以及GAD-Ab阳性率明显高于T2DM组,差异有统计学意义（P<0.05）。IAA-Ab、ICA-Ab以及GAD-Ab阳性组和阴性组的空腹胰岛素浓度比较,差异有统计学意义（P<0.05）,空腹葡萄糖和空腹C-肽比较,差异无统计学意义（P>0.05）。结论糖尿病患者检测自身抗体,对糖尿病的早期诊断、分型和治疗有很大的指导意义。

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	鲍彩丽
	俞莹
	刘雯
	应筱雯
	杜山青
	吴迪
	龚玲
	汤园园

关键词 ：抗胰岛细胞抗体, 抗胰岛素抗体, 抗谷氨酸脱羧酶抗体, 糖尿病

Abstract：Objective To analyze and discuss the clinical application value of detection islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies in the diagnosis of diabetes mellitus.Methods 230 cases of clinical diabetes mellitus patients admitted to our hospital from August 2013 to August 2016 were selected as the study subjects.The indexes of islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies were detected.The T1DM group and T2DM group were divided according to antibody negative/positive classification,the FBG,INS and CP concentrations of two groups were observed.Results The positive rate of islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies of patients in T1DM group was significantly higher than that in T2DM group,and the differences were statistically significant (P<0.05).The INS concentrations of islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies of positive group and negative group were compared,and the differences were statistically significant (P<0.05);the indexes of FBG and CP of islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies of positive group and negative group were compared,and the difference was not statistically significant (P>0.05).Conclusion For diabetes mellitus patients,the detection of insulin autoantibodies have great guiding significance in the early diagnosis,typing and treatment.

Key words： Islet cell antibodies Anti-insulin antibodies Glutamic acid decarboxylase antibodies Diabetes mellitus

收稿日期: 2017-07-10

PACS:

R587.1

通讯作者: ^▲汤园园（1969-）,女,上海人,主管技师,研究方向：临床检验

作者简介: 鲍彩丽（1981-）,女,安徽亳州人,本科,主管医师,研究方向：临床检验（生化专业）

引用本文:

鲍彩丽, 俞莹, 刘雯, 应筱雯, 杜山青, 吴迪, 龚玲, 汤园园. 胰岛自身抗体和生化指标在糖尿病分型诊断中的应用价值[J]. 中国当代医药, 2017, 24(24): 112-114.
BAO Cai-li, YU Ying, LIU Wen, YING Xiao-wen, DU Shan-qing, WU Di, GONG Ling, TANG Yuan-yuan. The application value of insulin autoantibodies and biochemical indexes in the type diagnosis of diabetes mellitus. 中国当代医药, 2017, 24(24): 112-114.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2017/V24/I24/112

[10]	邱阳,郭慧淑,刘越坚,等.免疫印迹法检测胰岛自身抗体系列在糖尿病分型诊断中的应用[J].中国老年学杂志,2013,33（7）：1517-1518.
[11]	张成诗,吴兵,魏光明,等.糖尿病自身抗体联合检测在糖尿病分型中的应用价值研究[J].中国实验诊断学,2014, 18（6）：931-933.
[13]	易波,黄干,谢志国,等.胰岛自身抗体检测及标准化研究进展[J].中华糖尿病杂志,2015,7（8）：521-524.
[14]	陈双,付麒,顾愹,等.1型糖尿病临床诊断模型的建立[J].中华糖尿病杂志,2016,8（10）：598-602.
[15]	李萍,梁琳琅,陈若然,等.僵人综合征合并成人隐匿性自身免疫糖尿病一例及文献回顾[J].中华糖尿病杂志,2017,9（1）：50-53.
[1]	周晖,李正康,徐晓明,等.胰岛自身抗体和生化指标在糖尿病分型诊断中的应用价值[J].重庆医学,2016,45（21）：2909-2913.
[3]	李翠,李丽.胰岛自身抗体测定对糖尿病分型的临床意义[J].现代中西医结合杂志,2013,22（1）：85-86.
[4]	杨秉潜.胰岛自身抗体检测在糖尿病分型诊断中的价值[J].检验医学与临床,2013,10（20）：2741-2742.
[6]	施云,沈捷,顾愹,等.1型糖尿病患者人类白细胞抗原Ⅰ类基因与胰岛功能及胰岛自身抗体的关系[J].中华糖尿病杂志,2013,5（7）：392-397.
[2]	Wilmot-Roussel H,Lévy DJ,Carette C, et al .Factors associated with the presence of glutamic acid decarboxylase and islet antigen-2 autoantibodies in patients with long-standing type 1 diabetes[J].Diabetes Metab,2013,39（3）：244-249.
[5]	Ly LD,Twigg SM,Tran DT, et al .Most type 1 diabetes presenting as diabetic ketoacidosis in Vietnamese people is negative for pancreatic islet cell autoantibodies[J].Diabetes Res Clin Pract,2012,96（3）：63-65.
[7]	Liu J,Lei DP,Jin T, et al .Altered expression of miR-21 and PTEN in human laryngeal and hypopharyngeal squamous cell carcinomas[J].Asian Pac J Cancer Prev,2011,12（10）：2653-2657.
[8]	Siraj ES,Rogers DG,Gupta MK, et al .A simple screening method for individuals at risk of developing type 1 diabetes: measurement of islet cell autoantibodies （GADA,IA-2A,and IAA) on dried capillary blood spots collected on filter paper[J].Horm Metab Res,2012,44（11）：855-860.
[9]	Kong YH,Kim MS,Lee DY.Comparison of the prevalence of islet autoantibodies according to age and disease duration in patients with type 1 diabetes mellitus[J].Ann Pediatr Endocrinol Metab,2013,18（2）：65-70.
[12]	Wang Y,Zhu Y,Lv P, et al .The role of miR-21 in proliferation and invasion capacity of human tongue squamous cell carcinoma in vitro[J].Int J Clin Exp Pathol,2015,8（5）：4555-4563.