Abstract：Objective To investigate the clinical efficacy and safety evaluation of doxycycline joint clindamycin for Mycoplasma infection of female genital tract.Methods 129 cases with Mycoplasma infection of female genital tract were divided into treatment group（65 cases）and control group（64 cases）by different treatments in our hospital department of gynaeology from January 2013 to October 2014.The treatment group were given doxycycline by oral joint clindamycin by intrarenous，while the control group were given doxycycline alone.Curative effect of two groups were observed and safety were evaluated.Results The total effective rate was 96.92%in the treatment group，higher than 79.69%in the control group，the difference between the two groups was statistically significant（P＜0.05）.The adverse events occurred in patients of the treatment group was 15.38%，compared with 14.06%in the control group，the difference between the two groups was not statistically significant（P＞0.05）.Conclusion For Mycoplasma infection of female genital tract，the treatment of doxycycline joint clindamycin has a better clinical efficacy and safety.
Kwak DW，Hwang HS，Kwon JY，et al.Co-infection with vaginal Ureaplasma urealyticum and Mycoplasma hominis increases adverse pregnancy outcomes in patients with preterm labor or preterm premature rupture of membranes［J］. J Matern Fetal Neonatal Med，2014，27（4）：333-337.
［4］
Le Guern R，Loïez C，Loobuyck V，et al.A new case of Mycoplasma hominis mediastinitis and sternal osteitis after cardiac surgery［J］.Int J Infect Dis，2015，（31）：53-55.
［5］
Ratliff AE，Duffy LB，Waites KB，et al.Comparison of the illumigene Mycoplasma DNA amplification assay and culture for detection of Mycoplasma pneumoniae［J］.J Clin Microbiol，2014，52（4）：1060-1063.
Pinna GS，Skevaki CL，Kafetzis DA.The significance of Ureaplasma urealyticum as a pathogenic agent in the paediatric population［J］.Curr Opin Infect Dis，2006，19（3）：283-289.
［9］
Abele-Horn M，Wolff C，Dressel P，et al.Polymerase chain reaction versus culture for detection of Ureaplasma urealyticum and Mycoplasma hominis in the urogenital tract of adults and the respiratory tract of newborns［J］.Eur J Clin Microbiol Infect Dis，1996，15（7）：595-598.
［11］
Ye G，Jiang Z，Wang M，et al.The resistance analysis of Ureaplasma urealyticum and Mycoplasma hominis in female reproductive tract specimens［J］.Cell Biochem Biophys，2014，68（1）：207-210.
［12］
Bayraktar MR，Ozerol IH，Gucluer N，et al.Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women［J］.Int J Infect Dis，2010，14（2）：e90-e95.
［13］
Bebear CM，Renaudin H，Charron A，et al.In vitro activity of trovafloxacin compared to those of five antimicrobials against Mycoplasmas including Mycoplasma hominis and Ureaplasma urealyticum fluoroquinolone resistant isolates that have been genetically characterized［J］.Antimicrob Agents Chemother，2000，44（9）：2557-2560.
Ocvirk J，Heeger S，McCloud P，et al.A review of the treatment options for skin rash induced by EGFR-targeted therapies：Evidence from randomized clinical trials and a meta-analysis［J］.Radiol Oncol，2013，47（2）：166-175.
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