Abstract：Objective To explore the effects of different treatment program in rheumatoid arthritis（RA）.Methods 250 patients with RA who got first diagnosis in department of rheumatism of Chenghai people′s hospital from June 2014 to August 2015 were selected as study objects.250 RA patients were randomly divided into methotrexate（MTX）group，leflunomide（LEF）group，MTX+LEF group，MTX+tripterygium glycosides group and MTX+total glucoside of paeony group according to the admission order，and each group was 50 cases.The effects adverse and curative effect among five groups were observed.Results Two weeks after followed up treatment，the clinical and laboratory efficacy of the five groups were similar，and the difference had no statistical significance（P＞0.05）；Four，twelve and twenty-four weeks after followed up，the clinical and laboratory efficacy in MTX+LEF group，LEF group，MTX+tripterygium glycosides group and MTX+total glucoside of paeony group was better than that of MTX group respectively，and the difference was statistical significance（P＜0.05）.The adverse effects in MTX+LEF group was 20.00%，obvious lower than that was 38.00%in MTX group，and the difference was statistical significance（χ2=3.93，P＜0.05）.Conclusion The effects of MTX+LEF in treating RA is exact，and with less adverse effects.It should be major recommended use in clinic.
林伟耿;林秋强;陈韧. 不同治疗方案对类风湿关节炎的效果观察[J]. 中国当代医药, 2016, 23(16): 4-7转11.
LIN Wei-geng;LIN Qiu-qiang;CHEN Ren. Effects observation of different treatment program in rheumatoid arthritis. 中国当代医药, 2016, 23(16): 4-7转11.
京公网安备 11010502046607号