Abstract：［Abstract］Objective To establish a rapid and accurate，environmental protection，high sensitivity method for the determination of antazoline hydrochloride.Methods The potentiometric titration was performed on Mettler DL-50 and Mettler DG115-GC using 5.0 ml hydrochloric acid and 50 ml ethylalcohol as solvent and Sodium hydroxide as titrantion.The potentiometric titration in contrastwas compared with non-aqueous titration method.Results The linear range ofweight was 0.12 to 0.35g（r=0.9998，n=6），the RSD of accuracy experiment and repeatability experimentwere 0.3%，0.2%and 0.3%.Potentiometric titration and non-aqueous titration results were consistent.Conclusion Potentiometric titration method is fast，accurate，sensitive，and elimination of the existingmethods of environmental pollution factors，can be used as bupropion hydrochloride hismethod for the determination of imidazoline
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