Abstract：Objective To investigate the effect of Azithromycin combined with Fluticasone Propionate on pediatric chronic cough caused by Mycoplasma pneumoniae (MP) infection. Methods A total of 126 children with MP infection and chronic cough admitted to the Department of Neonatology, the First Affiliated Hospital of Guangxi University of Science and Technology from September 2018 to August 2019 were selected as the research objects, and they were divided into observation group and control group by random number table method, 63 cases in each group. The control group was treated by Azithromycin, and the observation group was given the same but combined with Fluticasone Propionate. The clinical efficacy, fractional exhaled nitric oxide (FeNO), C-reactive protein (CRP), eosinophil (EOS) counts,and cough relapse rates of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). The serum CRP, EOS and FeNO in the observation group were lower than those of the control group, the differences were statistically significant(P＜0.05). The recurrence rate of cough in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion The treatment of Azithromycin combined with Fluticasone Propionate in children with chronic cough with MP infection can further improve the treatment effect and reduce the recurrence.
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