Clinical efficacy and safety of Pramipexole combined with Levodopa in the treatment of Parkinson′s disease
MA Chun-li1 XU Tian-yin1 WANG Yi-ning2
1. The First Department of Neurology, the Second Affiliated Hospital of Mudanjiang Medical University, Heilongjiang Province, Mudanjiang 157000, China;
2. The First Department of Cardiology, the Second Affiliated Hospital of Mudanjiang Medical University, Heilongjiang Province, Mudanjiang 157000, China
Abstract：Objective To investigate the clinical effect and safety of Pramipexole combined with Levodopa in the treatment of Parkinson′s disease. Methods From January 2017 to December 2018, 100 patients with Parkinson′s disease treated in our hospital were selected as subjects, and divided into control group (n=50) and study group (n=50) by random lottery method. Patients in the control group were treated with Levodopa, while patients in the study group were treated with Pramipexole combined with Levodopa. The clinical treatment effect of patients of the two groups was compared, the concise health status scale (SF-36) scores and the Hamilton depression scale (HAMD-17) scores of the two groups before and after treatment were compared, and the occurrence of adverse reactions of patients in the two groups was compared. Results The total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P＜0.05). After treatment, indexes of SF-36 scores in the study group were higher than those in the control group, and the differences were statistically significant (P＜0.05). After treatment, the HAMD-17 score in the study group was lower than that in the control group, with statistically significant difference (P＜0.05).The total incidence of adverse reactions in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The application of Pramipexole combined with Levodopa in the treatment of Parkinson′s disease can effectively improve the symptoms of the disease, improve the clinical efficacy, and has high safety. It has important clinical application value.
马春丽；徐甜颖；王以宁. 普拉克索联合左旋多巴治疗帕金森病的临床效果及安全性[J]. 中国当代医药, 2020, 27(19): 81-84.
MA Chun-li；XU Tian-yin；WANG Yi-ning. Clinical efficacy and safety of Pramipexole combined with Levodopa in the treatment of Parkinson′s disease. 中国当代医药, 2020, 27(19): 81-84.
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