Abstract：Objective To explore the clinical effect of Hydrotalcite combined with quadruple therapy in the treatment of helicobacter pylori(Hp)infection and duodenal ulcer(DU).Methods A total of 108 DU patients with HP infection who were visited in the outpatient department of Qianjiang Central Hospital Affiliated to Changjiang University from May 2017 to December 2019 were selected.According to the random digital table method,they were divided into control group(n=54)and study group(n=54).The control group was given a quadruple regimen of Colloidal Bismuth Tartrate,Pantoprazole,Clarithromycin and Amoxicillin.The study group was combined with Hydrotalcite on this regimen.The clinical efficacy and Hp eradication rate of the two groups of patients after treatment were compared,and the changes in serum inflammatory factor levels before and after treatment were compared.Results The total effective rate of treatment and Hp eradication rate in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the levels of inflammatory factors between the two groups before treatment(P>0.05).After treatment,the levels of serum interleukin-6(IL-6)and tumor necrosis factor alpha (TNF-α)in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion Hydrotalcite combined with quadruple therapy can improve the clinical symptoms of DU patients with Hp infection,increase the Hp eradication rate,reduce the level of inflammatory mediators,Improve the degree of inflammation of gastric antrum mucosa,and enhance the efficacy.
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