中药外敷对ICU 重症患者深静脉血栓的预防效果

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摘要目的探讨中药外敷对ICU 重症患者深静脉血栓的预防效果。方法选取2020年1月至2021年1月深圳平乐骨伤科医院ICU 收治的128 例重症患者作为研究对象，按随机数字表法分为对照组（64 例）和观察组（64 例）。对照组予以抗凝治疗，观察组在对照组的基础上加用中药外敷，两组持续用药10 d。比较两组凝血功能、血液流变学指标及深静脉血栓发生率。结果治疗前，两组的凝血功能[凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT），D-二聚体（D-D）]比较，差异无统计学意义（P＞0.05）；治疗后，两组的PT、APTT、TT 长于本组治疗前，两组的D-D 水平低于本组治疗前，差异有统计学意义（P＜0.05）；治疗后，观察组的PT、APTT、TT 长于同期对照组，观察组的D-D 水平低于同期对照组，差异有统计学意义（P＜0.05）。治疗前，两组的血液流变学指标[全血高切黏度（HBV）、全血低切黏度（LBV）、血浆黏度（PV）]比较，差异无统计学意义（P＞0.05）；治疗后，两组的HBV、LBV、PV 水平低于本组治疗前，差异有统计学意义（P＜0.05）；治疗后，观察组的HBV、LBV、PV 水平低于同期对照组，差异有统计学意义（P＜0.05）。观察组的深静脉血栓发生率低于对照组，差异有统计学意义（P＜0.05）。结论中药外敷可改善ICU 重症患者凝血功能，降低血液黏度，减少深静脉血栓发生，值得广泛应用。

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	王志刚
	杜丽娟
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	唐何军
	陈兴贤

关键词 ： ICU 重症患者, 中药外敷, 深静脉血栓, 凝血功能, 血液流变学指标

Abstract：Objective To explore the preventive effect of traditional Chinese medicine external application on deep vein thrombosis in ICU severe patients.Methods A total of 128 severe patients admitted to the ICU of Shenzhen Pingle Orthopedics and Injury Hospital from January 2020 to January 2021 were selected as the study subjects, and divided into the control groups (64 cases) and the observation groups (64 cases) according to the random number table method.The control group received anticoagulation treatment, and the observation group applied traditional Chinese medicine on the basis of the control group, the two groups continued medication for 10 days.The blood coagulation function, the blood rheology index and the incidence of the deep vein thrombosis were compared between the two groups.Results Before treatment, the comparison of coagulation function (prothrombin time [PT], activated partial thromboplastin time [APTT],thrombin time [TT], D-dimer [D-D]) were compared between the two groups, with no statistical significant differences(P>0.05).After treatment, PT, APTT, and TT in the two groups were longer than those before treatment in this group,and the D-D levels was lower than that before treatment in this group, and the differences were statistical significant(P<0.05).After treatment, the PT, APTT and TT in the observation group were longer than those in the control group at the same period, and the D-D levels in the observation group was lower than that in the control group at the same period, and the differences were statistical significant (P<0.05).Before treatment, the blood rheological indexes (high blood viscosity [HBV], low blood viscosity [LBV], and plasma viscosity [PV]) were compared between the two groups, with no statistical significant differences (P>0.05).After treatment, the levels of HBV, LBV, and PV in the two groups were lower than those before treatment in this group, and the differences were statistical significant (P<0.05).After treatment,the levels of HBV, LBV, and PV in the observation group were lower than those in the control group at the same period, and the differences were statistical significant (P<0.05).The incidence of deep vein thrombosis in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05).Conclusion External application of traditional Chinese medicine can improve coagulation function, reduce blood viscosity and reduce severe ICU thrombosis, which is worth extensive application.

Key words： ICU severe Traditional Chinese medicine external application Deep vein thrombosis Coagulation function Blood rheological indexes

引用本文:

王志刚；杜丽娟；宋璐；唐何军；陈兴贤. 中药外敷对ICU 重症患者深静脉血栓的预防效果[J]. 中国当代医药, 2021, 28(36): 154-157.
WANG Zhigang； DU Lijuan； SONG Lu； TANG Hejun； CHEN Xingxian. Preventive effect of traditional Chinese medicine external application on deep vein thrombosis in ICU severe patients. 中国当代医药, 2021, 28(36): 154-157.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2021/V28/I36/154

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