Abstract:Objective To observe the effect of Levodopa and Benserazide Hydrochloride Tablets combined with Pramipexole in the treatment of Parkinson′s disease. Methods Ninety-four patients with Parkinson′s disease admitted to the Internal Medicine Department of Dianbai District People′s Hospital of Maoming City, Guangdong Province from October 2018 to June 2020 were selected as the research subjects. They were divided into a control group (n=47) and an observation group (n=47)using the odd/even number distribution method.Patients in the control group were treated with Levodopa and Benserazide Hydrochloride Tablets.Patients in the observation group were provided with Levodopa and Benserazide Hydrochloride Tablets combined with Pramipexole. The Webster comprehensive rating scale (Webster) score and the Parkinson′s disease rating scale Ⅲpart motor examination evaluation (UPDRS Ⅲ) score before and after medication were compared between the two groups, and the total effective rate of the two groups was compared. Results Webster and UPDRS Ⅲscores before medication in the two groups were compared, and the differences were not statistically significant (P>0.05). After two months of medication, the Webster and UPDRS Ⅲscores of the two groups were lower than those before medication, and the differences were statistically significant (P<0.05). The Webster and UPDRS Ⅲscores of the observation group after two months of medication were lower than those of the control group, the differences were statistically significant (P<0.05). The total effective rate of observation group (89.36%) was higher than that of control group (61.70%), and the difference was statistically significant (P<0.05). Conclusion The effectiveness of the treatment of patients with Parkinson′s disease is significantly improved in the combination of Levodopa and Benserazide Hydrochloride Tablets and Pramipexole compared with Levodopa and Benserazide Hydrochloride Tablets alone. It can effectively improve the clinical symptoms of patients and control the development of their disease. It has high medicinal value and is worthy of clinical application.
谢盛. 多巴丝肼片联合普拉克索治疗帕金森病的效果[J]. 中国当代医药, 2021, 28(16): 89-92.
XIE Sheng. Effect of Levodopa and Benserazide Hydrochloride Tablets combined with Pramipexole in the treatment of Parkinson′s disease. 中国当代医药, 2021, 28(16): 89-92.