Abstract：Objective To explore the related factors of postoperative symptom aggravation in surgical treatment of myasthenia gravis(MG).Methods The clinical data of 128 patients with MG who underwent thymectomy in the Second Affiliated Hospital of Zhengzhou University from June 2013 to June 2019 were retrospectively analyzed.The preoperative and postoperative classifications of each patient were evaluated according to the surgical classification standard of MG,and patients were divided into the addition group and the stable group based on whether they were aggravated.The addition group:after surgery,the symptoms of MG patients were aggravated during the hospitalization(type increased),or the amount of medication requirement was increased.The stable group:after surgery,the symptoms of MG patients were relieved(type reduced)or unchanged(type unchanged)during the hospitalization,or the amount of medication needed to maintain current symptoms was reduced.Single factor and multivariate Logistic regression were used to analyze the related factors of postoperative symptoms aggravated.Results Of the 128 patients,40 cases were in the addition group,and 88 cases were in the stable group.There were statistically significant differences in the surgical methods,Osserman classification and pathological types of thymus between the two groups(P＜0.05).Logistic regression analysis showed that surgical methods,Osserman classification,and thymus pathological type were related factors affecting postoperative symptoms of MG patients(P＜0.05).In Osserman classification,compared with typeⅠMG patients,patients of typesⅡB andⅢhad a higher probability of postoperative aggravation of symptoms.Conclusion Thymectomy is the main surgical treatment for MG.The choice of surgical methods,Osserman classification and the pathological type of thymoma are related factors for the aggravation of symptoms in MG patients after surgical treatment.Choosing a reasonable surgical method,combined with the MG Osserman classification and the pathological type of the thymus,has guiding significance for the prevention of postoperative symptoms of MG.
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