Abstract：[Abstract]Objective To investigate the clinical efficacy and safety of simple nasal obstructive continuous positive airway pressure oxygen（CPAP）therapy for neonatal respiratory distress syndrome（RDS）.Methods A total of 40 children with RDS treated in our hospital from October 2015 to October 2017 were selected and divided into observation group and control group by random number table method，20 cases in each group.The control group was treated with pulmonary surfactant; the observation group was treated with CPAP，and the clinical efficacy and safety were analyzed.Results There were no significant difference in arterial partial pressure of oxygen（PaO2），arterial partial pressure of carbon dioxide（PaCO2）and oxygen saturation（SaO2）between the two groups before treatment（P＞0.05）.After treatment，PaO2，PaCO2 and SaO2 of the two groups were significantly improved（P＜0.05）.After treatment，the PaO2 and SaO2 indexes of the observation group were higher than those of the control group，and the PaCO2 indexes was lower than that of the control group，the differences were statistically significant（P＜0.05）.The rate of intraventricular hemorrhage and mortality in the observation group were lower than those in the control group，and the treatment time of positive pressure breathing was shorter than that in the control group，the differences were statistically significant（P＜0.05）.Conclusion CPAP can effectively improve the clinical symptoms of RDS in children，and it is safe and reliable，which is worthy of clinical application.
Principi N，Di Pietro GM，Esposito S.Bronchopulmonary dysplasia：clinical aspects and preventive and therapeutic strategies[J].J Transl Med，2018，16（1）：36-42.
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