Abstract：Objective To explore the significance of CCL-18 and CyclinD1 in the detection of oral and maxillofacial malignant tumors.Methods Sixty four patients with oral and maxillofacial malignant tumors admitted to our hospital from February 2016 to February 2018 were selected as the analysis group,and 64 healthy volunteers at the same period were selected as the reference group,serum tests were performed in both groups.Routine examinations were performed once in the control group.The patients in the analysis group were tested before and 1 month after the treatment,preoperative serum levels of CCL-18 and CyclinD1 were compared between the two groups.The levels of CCL-18 and CyclinD1 in serum before and after operation,different pathological types,lymph node metastasis and different clinical stages were compared and analyzed.Results The levels of CCL-18 and CyclinD1 in serum of the analysis group before operation were higher than those of the control group,the differences were statistically significant(P＜0.05).The levels of CCL-18 and CyclinD1 in the serum of the analysis group at 1 month after operation were lower than those before operation,and the differences were statistically significant(P＜0.05).The level of CCL-18 in serum of patients without lymph node metastasis was significantly lower than that of patients with lymph node metastasis,the difference was significant(P＜0.05).The level of CCL-18 in serum of patients with stage II was significantly higher than that of patients with other 3 stages,the difference was significant(P＜0.05).The level of serum Cyclin D1 in patients with stage II was significantly lower than that in patients with other 3 stages,the difference was significant(P＜0.05).Conclusion Compared with healthy volunteers,the serum levels of CCL-18 and CyclinD1 in patients with oral and maxillofacial malignant tumors were significantly higher,which can be considered as an assistant diagnostic method for maxillofacial malignant tumors,and have a certain reference value.
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