Abstract：ObjectiveTo observe the clinical effect of Shugan Jieyu Capsules combined with Duloxetine in the treatment of depression in patients with parkinson disease (PD).Methods73 PD patients with depression treated in outpatient of the psychiatry department of our hospital from February 2016 to June 2017 were selected as object and they were randomly divided into the control group (36 cases)and combined group (37 cases).Patients in the control group were treated with Duloxetine Hydrochloride Enteric-coated Tablets,while the patients in the combined group were treated with Shugan Jieyu Capsules at the same time.4weeks were a course of treatment and the patients were treated continuously for 2 courses.The score of HAMD,UPDRS-Ⅲand ADL before treatment and at the fourth,eighth week of treatment were compared in patients between the two groups.At the eighth week of treatment,the treatment effect between the two groups was compared according to HAMD reduction rate,and the incidence of adverse reactions during the treatment of the two groups was compared at the same time.ResultsAt the fourth and eighth weeks treatment,the score of HAMD,UPDRS-Ⅲin the two groups were significantly decreased,ADL score was obviously increased,and there was a statistical difference compared with before treatment(P＜0.05).At the eighth weeks treatment,the score of HAMD and UPDRS-Ⅲ of the patients in the combined group were significantly lower than those in the control group(P＜0.05)and at the fourth and eighth weeks treatment,ADL score of the patients in the combined group was significantly higher than that in the control group(P＜0.05).At the eighth weeks,the total effective rate of the patients in the combined group was 91.89%,which was significantly higher than that of the control group (71.31%)(P＜0.05).The incidence of adverse drug reactions in the combined group was 13.51%,compared with 19.44%in the control group,the difference was not statistically significant(P＞0.05).ConclusionThe combination of Shugan Jieyu Capsules combined with Duloxetine is effective in the treatment of PD complicated with depression,both can work together to strengthen the effect of depressive symptoms,help improve the daily living ability and exercise ability of patients,and can reduce the incidence of adverse drug reaction,it is worthy of clinical promotion and application.
姚旭东;刘芳. 疏肝解郁胶囊联合度洛西汀治疗帕金森患者抑郁的临床效果[J]. 中国当代医药, 2018, 25(2): 157-159转171.
YAO Xu-dong; LIU Fang. Clinical effect of Shugan Jieyu Capsules combined with Duloxetine in the treatment of depression in patients with parkinson disease. 中国当代医药, 2018, 25(2): 157-159转171.
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