Changes of the level of serum Leptin,TNF-α and IL-6 and its clinical significance in the aged patients with femoral neck fracture before and after total hip replacement
LI Liang-qi ZHAO Chong-hai WANG Hai-tao CHAI Guo-lu
Department of the First Orthopaedy,Orthopaedy Hospital of Jiamusi City in Heilongjiang Province,Jiamusi 154002, China
Abstract：ObjectiveTo study the level changes of serum Leptin,TNF-α and IL-6 and its clinical significance in the aged patients with femoral neck fracture before and after total hip replacement.Methods56 cases of aged patients with femoral neck fracture who were treated by operation in Jiamusi Orthopaedy Hospital from January 2015 to June 2016 were selected as the observation group,at the same period,50 normal aged individuals were selected as the control group.The serum levels of Leptin,TNF-α and IL-6 were measured in the control group and in the observation group before operation and at the 1st,3nd,7th,14th d after total hip replacement.ResultsThe serum levels of Leptin,TNF-α and IL-6 were significantly higher in aged patients with femoral neck fracture than that the normal aged individuals,the differences were statistically significant(P＜0.01).The serum levels of Leptin,TNF-α and IL-6 were increased grandually at the 1st,3nd,7th d after total hip replacement in the aged patients with femoral neck fracture,the differences were statistically significant(P＜0.01).ConclusionThe high levels of Leptin,TNF-α and IL-6 may involve the development of acute traumatic inflammatory response,which can effect the bone healing.
李良琦 ；赵崇海 ；王海涛 ；柴国禄. 老年股骨颈骨折患者全髋关节置换手术前后血清Leptin、TNF-α、IL-6水平的变化及临床意义[J]. 中国当代医药, 2017, 24(31): 98-100.
LI Liang-qi；ZHAO Chong-hai；WANG Hai-tao ；CHAI Guo-lu. Changes of the level of serum Leptin,TNF-α and IL-6 and its clinical significance in the aged patients with femoral neck fracture before and after total hip replacement. 中国当代医药, 2017, 24(31): 98-100.
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