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2020 Vol. 27, No. 2
Published: 2020-01-18
 
 
4 Analysis the tolerance and pharmacokinetics of Tefentai Tablets in healthy volunteers
LIANG Hong; LI Jie; WU Yu-chun; CHENG Nan; CHEN Hua-rong; WU Gui-hui
Objective To analyze the tolerance and pharmacokinetics of Tefentai Tablets in healthy volunteers. Methods In this study,a randomized,double-blind method was used to study 26 healthy volunteers from January to June 2017,all patients were given 300 and 600 mg of Tefentanil,two doses of which were given single or multiple times,once a day for multiple times,7 days in a row,in which the drug elution cycle was 2 weeks.The pharmacokinetic parameters (the highest blood concentration [Cmax],the lowest blood concentration [Cmin],the average blood concentration[Cavg],the curve area of blood concentration over a period of time [AUC0-t],the infinite curve area of blood concentration[AUC0-∞] and accumulation index) were measured by high performance liquid chromatography at different time points.Pharmacokinetic parameters,high performance liquid chromatography characteristics and related adverse reactions were analyzed. Results The peak time (Tmax) was (1.02±0.13) h,and the half-life (t1/2) was (3.08±0.09) h after taking different doses of Tifentai Tablets for many times in healthy volunteers.The Tmaxof M8 was (3.05±0.07) h and t1/2was(9.56±0.67) h;The Tmaxof M9 was (4.11±0.15) h and T1/2was (6.17±0.21) h.At the dosage of 300 mg,there were no significant differences in Cmax,Cmin,Cavg,AUC0-t,AUC0-∞and accumulation index between multiple and single administration of Tifental (P>0.05).AUC0-tand AUC0-∞in multiple administration of metabolite N-benzoyl-O-(dimethylaminoethyl)-L-tyrosine (M8) and metabolite N-benzoyl-L-tyrosine-o-(N-oxidation-dimethylaminoethyl) - L-tyrosine(M9) were significantly higher than those of single administration (P<0.05).Cmaxof M9 multiple administration was higher than that of single administration,the difference was statistically significant (P<0.05).At the dosage of 600 mg,Cmaxin Tifental of multiple administration was higher than that of single administration,the difference was statistically significant (P<0.05).There were no significant differences in Cmin,Cavg,AUC0-t,AUC0-∞,accumulation index between multiple and single administration of Tifental (P>0.05).Cmaxand AUC0-tin multiple administration of M8 and M9 were significantly higher than that of single administration,the differences were statistically significant (P<0.05).The AUC0-∞of M9 multiple administration was higher than that of single administration,the difference was statistically significant (P<0.05).At the dose of 600 mg,repeated administration increased Cmax of Tifental,but had no significant effect on AUC0-∞of its exposure.The Cmaxof metabolites M8 and M9 increased,and the exposure of AUC0-∞increased.After several times of oral administration (doses of 300 and 600 mg) of Tifentai Tablets to healthy volunteers,a case of adverse event with foreign body sensation occurred in one volunteer at the dose of 600 mg,which was determined to be unrelated to the drug,and no volunteer withdrew from the trial due to adverse event. Conclusion Tifentai Tablets 600 mg dose not show obvious accumulation effect and high safety,in order to obtain better antiviral effect,it is suggested that the daily reference dose be 600 mg.
2020 Vol. 27 (2): 4-8 [Abstract] ( 86 ) HTML (53 KB)  PDF  (0 KB)  ( 11 )
9 Injury mechanism study of rs3775291 mutation of Toll-like receptor 3 gene in acute and chronic myocardial ischemia of diabetes mellitus rats
SHAO Liang； ZHANG Ping； CAI Xin-yong； XIAO Bin； MEI Song-bei
Objective To explore the injury mechanism of Toll-like receptor 3 (TLR3) gene rs3775291 mutation in acute and chronic myocardial ischemia of diabetes mellitus rats.Methods Eighty gene knockout SD rats were selected as the research objects from the Experimental Animal Center of Nanchang University from January to April 2019.They were divided into wild-type group (n=40) and mutant type group (n=40) by random number table method.The rats in the wild-type group were only silk thread passed through coronary artery but left ventricular branch was not ligated,and normal saline was injected through tail vein.In the mutant type group,TLR3 gene knockout rats were selected to make the model.The TLR3,nuclear factor κB (NF-κB) protein expressions,chemokine 10 (IP-10),interleukin 8 (IL-8),and tumor necrosis factor α (TNF-α) levels were compared between the two groups.Results The TLR3 and NF-κB protein expressions in the mutant type group were higher than those in the wild-type group,with statistically significant differences (P<0.05).There were no significant differences in the levels of IP-10,IL-8 and TNF-α between the two groups (P>0.05).Conclusion In the diabetes mellitus rat model of acute and chronic myocardial ischemia,the expression levels of TLR3 gene and protein were significantly increased,and the levels of inflammatory indicators were also increased.The mutation of TLR3 gene rs3775291 site is closely related to the injury mechanism.
2020 Vol. 27 (2): 9-11 [Abstract] ( 92 ) HTML (32 KB)  PDF  (0 KB)  ( 9 )
12 Research progress of Anlotinib in the treatment of lung cancer
LI Lian-gang； JIANG Jun
Lung cancer is one of the most common malignant tumors.In recent years,incidence and mortality of lung cancer have been ranked first in China.When most lung cancers are found,they are already in the advanced stage,so the survival rate of patients is low and there is also a lack of effective treatment methods.Therefore,seeking new medication that can prolong the survival time of lung cancer patients is of more important value.As tumor treatment methods advance,the antiangiogenic drug Anlotinib developed independently by China has shown great antineoplastic effects in the treatment of lung cancer.At present,it has been applied to the third-line treatment of advanced lung cancer.However,there remain a lot of questions regarding the clinical application of Anlotinib.Further research on Anlotinib′s antineoplastic mechanism,combined treatment methods and biomarkers which predicate the efficacy can benefit more lung cancer patients.This article reviews the research advances of Anlotinib in the treatment of lung cancer.
2020 Vol. 27 (2): 12-14 [Abstract] ( 123 ) HTML (33 KB)  PDF  (0 KB)  ( 18 )
15 Research progress of gastric retention-type sustained and controlled release drug delivery system
WU Tian-yi; HU Ning; SUN Shu-ping

The gastric retention-type sustained and controlled release drug delivery system is a type of drug that can prolong the drug retention time in the stomach,increase the absorption of the drug in the gastrointestinal tract,or enhance the therapeutic effect of the drug in the stomach,reduce adverse reactions and the number of medications,and improve clinical efficacy new drug delivery system.By reviewing relevant literature in recent years at home and abroad,this article reviews the recent research progress of several gastric retention-type sustained and controlled release drug delivery system based on recent research hotspots of gastric-retentive preparations.In addition,the application of nanotechnology and 3D printing technology in the system of gastric retention and drug retention was introduced briefly,which provides a reference for the theoretical research and development of this type of drug delivery system.
2020 Vol. 27 (2): 15-17 [Abstract] ( 97 ) HTML (34 KB)  PDF  (0 KB)  ( 13 )
18 Research progress in the treatment of cesarean scars pregnancy
YUAN Bei-bei; XIANG Hui-zhen; LEI Dan
Cesarean section was originally used to solve the problems of dystocia,fetal distress,severe pregnancy complications,misalignment of the fetus,etc.However,in recent years,due to the influence of multiple factors such as society and individuals,with the liberalization of the "Two children" policy,the cesarean section rate has gradually increased,and postoperative complications have also increased,the incidence of one of the serious long-term complications-cesarean scars pregnancy (CSP) is also increasing.CSP if not timely diagnosis and treatment,can occur placenta implantation and uterine rupture,leading to massive bleeding,even maternal death and other serious complications.There is no uniform treatment plan for CSP.This paper reviews the research progress of CSP from the definition,incidence,pathogenesis,classification,diagnosis and treatment of CSP.
2020 Vol. 27 (2): 18-21 [Abstract] ( 99 ) HTML (46 KB)  PDF  (0 KB)  ( 17 )
22 Predictive value of plasma lactate and carboxyhemoglobin on long-term prognosis in patients with carbon monoxide poisoning
YIN Jing-yi； GUO Zhi-xing ； ZHONG Yi-qi ； LING Xiao-mei ； CHANG Li-ying ； XU Jin-ping ； ZHANG Yu-qi； LI Xiao-yue
Objective To explore the predictive value of plasma lactate and carboxyhemoglobin on long-term prognosis in patients with carbon monoxide poisoning (COP).Methods The clinical data of 108 COP patients admitted to the Emergency Department of the Second Affiliated Hospital of Guilin Medical University from January 2017 to January 2019 were collected,and they were divided into poor prognosis group (n=16) and good prognosis group (n=92) according to whether there were remaining neurological complications.The receiver operating characteristic (ROC) curve was used to analyze the predictive value of plasma lactate and carboxyhemoglobin for the long-term prognosis of patients with COP.Results The levels of plasma lactate and carboxyhemoglobin in the poor prognosis group were higher than those in the good prognosis group,and the differences were statistically significant (P<0.05).The areas under the ROC curve of plasma lactate and carboxyhemoglobin were 0.816 (95%CI: 0.682-0.949) and 0.672 (95%CI: 0.529-0.814),respectively.When the optimal threshold value of plasma lactate was 7.95 mmol/L,the sensitivity was 68.8% and the specificity was 94.6%.When the optimal threshold value of carboxyhemoglobin was 20.2%,the sensitivity was 93.8%and the specificity was 33.7%.The Youden index of the serial test was greater than that of the parallel test,and their sensitivity and specificity were 64.5%,96.4%,and 98.1%,31.9%,respectively.Conclusion Both carboxyhemoglobin and plasma lactate have certain value in predicting the long-term prognosis of patients with COP.The combination of plasma lactate value and carboxyhemoglobin concentration has a higher specificity for the prognosis of COP patients,which may be of more clinical value.
2020 Vol. 27 (2): 22-24转31 [Abstract] ( 93 ) HTML (36 KB)  PDF  (0 KB)  ( 15 )
25 Clinical effect of Metformin in the treatment of nonalcoholic fatty liver
YANG Gao-zhong； SUN Xia-lin； YANG Sheng-sheng； TANG Xiong
Objective To explore the clinical effect of Metformin in the treatment of nonalcoholic fatty liver.Methods Sixty patients with nonalcoholic fatty liver admitted to our hospital from April 2018 to April 2019 were randomly divided into control group and experimental group,with 30 cases in each group.The control group was treated with Polyene Phosphatidylcholine,and the experimental group was supplemented with Metformin on the basis of the control group.The therapeutic effect,liver function index,blood lipid level and insulin resistance index before and after treatment were compared between the two groups.Results The total effective rate of the experimental group was 93.3%,higher than 70.0% of the control group,the difference was statistically significant (P<0.05).The alanine aminotransferase,aspartate aminotransferase,triglyceride,total cholesterol and insulin resistance index in the experimental group were lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion Metformin assisted treatment of non-alcoholic fatty liver can improve the therapeutic effect of patients,improve the liver function index and blood lipid level of patients,which is worthy of clinical application.
2020 Vol. 27 (2): 25-27 [Abstract] ( 93 ) HTML (31 KB)  PDF  (0 KB)  ( 14 )
28 Changes of human leukocyte antigen-B27 and inflammatory indexs in patients with spondyloarthritis and its clinical significance
ZHANG Jia-yong; GUO Jin; SHEN Jie; CHEN Yu-ling
Objective To investigate the changes of human leukocyte antigen-B27 and inflammatory indexs in patients with spondyloarthritis (SpA) and its clinical significance.Methods A total of 196 cases of SpA patients admitted to our hospital from January 2014 to December 2018,which met the research conditions,were selected as the SpA group,and 200 cases of healthy physical examination patients who were examined in our hospital during the same period were selected as the healthy control group.Blood HLA-B27,tumor necrosis factor-α (TNF-α),C-reactive protein (CRP),urinary color doppler ultrasound and abdominal orthotopic X-ray were detected.The occurrence of urolithiasis in the two groups was observed and compared.HLA-B27 positive rate,TNF-α and CRP levels of patients with urolithiasis (+)SpA group and patients with urolithiasis (-) SpA group were compared.Results The incidence of urolithiasis in SpA group was 19.89% (35/176),which was higher than 3.00% (6/200) in healthy control group,the difference was statistically significant (P<0.01).The HLA-B27 positive rate in urolithiasis (+) SpA group (82.86%) was higher than that in urolithiasis (-) SpA group (60.99%),the difference was statistically significant (P<0.05).The levels of TNF-α and CRP in urolithiasis (+) SpA group were higher than those in urolithiasis (-) SpA group,the differences were statistically significant (P<0.05).Conclusion The incidence of urolithiasis in patients with SpA is high,the HLA-B27,TNF-α,and CRP have a certain predictive effect on the risk of urolithiasis.
2020 Vol. 27 (2): 28-31 [Abstract] ( 88 ) HTML (36 KB)  PDF  (0 KB)  ( 13 )
32 Effect of continued rehabilitation and discharge guidance on the quality of life in patients with schizophrenia
HE Jian-jun
Objective To explore the effect of continuous rehabilitation and discharge guidance on the quality of life in patients with schizophrenia.Methods A total of 200 patients with schizophrenia treated in our hospital from January 2016 to December 2017 were selected as subjects.According to the random number table method,they were divided into two groups,100 cases in each group.Patients in the control group were given routine rehabilitation and discharge guidance,while patients in the study group were given continuous rehabilitation and discharge guidance.The satisfaction of patients in the two groups was compared.The quality of life scores of the two groups were compared mmediately after discharge and at 1,3,6,9 and 12 months after discharge.Discharge recurrence rates were compared between the two groups.Results The satisfaction score of patients in the study group was (94.10±3.10) points,which was higher than that in the control group for (80.99±2.14) points,with statistically significant difference (P<0.05).The quality of life scores in the study group at 1,3,6,9 and 12 months after discharge were higher than those of the control group,and the differences were statistically significant (P<0.05).The recurrence rate of patients in the study group after discharge was 2% (2/100),which was lower than that in the control group for 14% (14/100),with statistically significant difference (P<0.05).Conclusion The effect of continuation of rehabilitation and discharge guidance for patients with schizophrenia can improve the patients′ satisfaction and quality of life,and reduce the recurrence rate of patients after discharge.It is worthy of clinical application.
2020 Vol. 27 (2): 32-34转38 [Abstract] ( 96 ) HTML (34 KB)  PDF  (0 KB)  ( 12 )
35 Clinical study on the anticoagulation effect of 4% Sodium Citrate sealing tube in hemodialysis catheters
WEI Yao-liang
Objective To compare the effect of 4% Sodium Citrate and heparin sodium on the sealing of continuous renal replacement therapy (CRRT) hemodialysis catheters.Methods A total of 100 critically ill patients who were treated with bedside CRRT treatment in the Department of Intensive Care Unit (ICU) of Chen Xing-hai Hospital in Zhongshan City from March 2018 to May 2019 were selected as the subjects of the study.The patients were divided into observation group and control group by the random number table method,with 50 patients in each group.In the observation group,4% Sodium Citrate was used to seal the tube,while in the control group,100 U/ml Heparin Sodium saline was used to seal the tube.Catheter indwelling time and ICU stay time were compared between the two groups.The incidence rates of pipe blockage,blood volume>15 ml withdrawn 6 s before extubation,ionic calcium<1.0 mmol/L,catheteral-related infection,bleeding and hematomas around the puncture point were compared between the two groups.Results There was no significant difference in the time of catheter indwelling between the observation group and the control group(P>0.05).There was no significant difference in the time of ICU stay between the observation group and the control group (P>0.05).The incidence rate of pipe blockage in the observation group was lower than that in the control group,the difference was statistically significant (P<0.05),and the incidence rate of blood volume >15 ml withdrawn 6 s before extubation in the observation group was higher than that in the control group,the difference was statistically significant (P<0.05).There were no significant differences in the incidence rates of ionic calcium <1.0 mmol/L,catheteralrelated infection,bleeding and hematomas around the puncture point between the two groups (P>0.05).Conclusion The application of 4% Sodium Citrate sealing tube in the treatment of CRRT can effectively reduce the incidence of adverse events under the premise of ensuring the therapeutic effect,which is worth popularizing in clinical practice.
2020 Vol. 27 (2): 35-38 [Abstract] ( 97 ) HTML (35 KB)  PDF  (0 KB)  ( 13 )
39 Clinical effect of Guizhi Decoction combined with Salmeteroticasone Aerosol in the treatment of bronchial asthma
CHEN Li-sheng ； XU Ai-ting ； FEI Chun-xian
Objective To observe the clinical effect of Guizhi Decoction combined with Salmeteroticasone Aerosol in the treatment of bronchial asthma.Methods A total of 80 patients with bronchial asthma admitted to our hospital from June 2017 to February 2019 were selected as the subjects of this study.The patients were randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with Salmeteroticasone Aerosol alone.On the basis of the treatment of the control group,patients in the observation group were given Guizhi Decoction,2 doses/d,once in the morning and once in the evening.The clinical treatment effect,the disappearance time of wheezing symptoms,levels of pulmonary function indexs (forced expiratory volume in 1 second [FEV1],forced vital capacity [FVC],FEV1/FVC) before and after treatment,and occurrence of adverse reactions in the two groups were compared.Results The total effective rate of the observation group was 95.00%,which was higher than that of the control group (80.00%),and the difference was statistically significant (P<0.05).The disappearance time of wheezing symptoms in the observation group was (5.3±0.6) d,which was shorter than that in the control group for (7.6±0.7) d,and the difference was statistically significant (P<0.05).Before treatment,the levels of pulmonary function indexs (FEV1,FVC,FEV1/FVC) were compared between the two groups,and the differences were not statistically significant (P>0.05).After treatment,the levels of pulmonary function indexs (FEV1,FVC,FEV1/FVC) in the observation group were higher than those in the control group,and the differences were statistically significant (P<0.05).After treatment,the levels of pulmonary function indexs (FEV1,FVC,FEV1/FVC) in the observation group were higher than those before treatment,and the differences were statistically significant (P<0.05).During the treatment period,4 cases (10.00%) of adverse reactions occurred during treatment in the control group and 2 cases (5.00%) in the observation group.There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Guizhi Decoction combined with Salmeteroticasone Aerosol has a significant effect on bronchial asthma,which can shorten the time of patients′ wheezing symptoms,improve patients′ pulmonary function and reduce adverse reactions.Therefore,it is worthy of clinical application and promotion.
2020 Vol. 27 (2): 39-41 [Abstract] ( 98 ) HTML (36 KB)  PDF  (0 KB)  ( 9 )
42 Clinical effect of Terbutaline and Tiotropium Bromide in the treament of patients with acute exacerbation of chronic obstructive pulmonary disease
LU Yu-lin； YUAN Hua-bao； LIU Xian-kui
Objective To investigate the clinical effect of Terbutaline and Tiotropium Bromide in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).Methods Retrospective analysis was performed on 90 cases of COPD patients admitted and treated in our hospital from January 2017 to February 2019 were selected as research objects,and they were divided into group A,B and C according to different treatment methods,with 30 cases in each group.Tiotropium Bromide was used in group A,Terbutaline in group B,and Terbutaline combined with Tiotropium Bromide in group C.The total therapeutic efficiency of the three groups was compared.And the pulmonary function indicators of the three groups were compared,such as the forced expiratory volume in the first second (FEV1),forced lung capacity (FVC),and the forced expiratory volume per second vs.forced vital capacity ratio(FEV1/FVC).The blood gas analysis indexs of the three groups were compared,such as hydrogen ion concentration index (pH value),partial arterial blood pressure of carbon dioxide (PaCO2),blood oxygen partial pressure (PaO2).The adverse reactions of the three groups were compared.Results There was no statistically significant difference in total effective rate of clinical treatment between group A and group B (P>0.05).The total effective rate of clinical treatment of group C was higher than that of group A and B,and the differences were statistically significant (P<0.05).After treatment,FEV1,FVC,FEV1/FVC in group A showed no statistically significant difference compared with group B (P>0.05).After treatment,FEV1,FVC and FEV1/FVC in group C were higher than those in group A and group B,with statistically significant differences (P<0.05).There was no statistically significant difference in pH value,PaCO2and PaO2between group A and group B after treatment (P>0.05).After treatment,PaO2in group C was higher than that in group A and group B,with statistically significant differences (P<0.05).After treatment,PaCO2in group C was lower than that in group A and group B,with statistically significant difference (P<0.05).There was no statistically significant difference in the total incidence of adverse reactions among the three groups (P>0.05).Conclusion Combining Tiotropium Bromide with Terbutaline can improve the clinical therapeutic effect,improve the pulmonary function and ensure the safety of treatment for patients with acute exacerbation of COPD.
2020 Vol. 27 (2): 42-45 [Abstract] ( 97 ) HTML (40 KB)  PDF  (0 KB)  ( 9 )
46 Clinical effect of T3-4sympathetic nerve chain resection under single-hole thoracoscope in the treatment of primary hand sweat
3-4sympathetic nerve chain resection under single-hole thoracoscope in the treatment of primary hand sweat[J]. 中国当代医药, 2020,27(2): 46-48')" href="#"> CHEN Hai-jun
Objective To investigate the clinical effect of T3-4sympathetic nerve chain resection under single-hole thoracoscope in the treatment of primary hand sweat.Methods Thirty-one patients with primary hand sweat treated in our hospital from December 2013 to December 2018 were selected as research objects,they were divided into observation group (15 cases) and control group (16 cases) according to different treatment methods.The control group received double-hole thoracoscopy surgery,and the observation group received single-hole thoracoscopy T3-4sympathectomy.The hospitalization time,intraoperative blood loss,visual analogue scale (VAS) score,high sensitivity C-reactive protein(hs-CRP),interleukin-6 (IL-6) and cortisol levels before and after surgery were compared between the two groups.Results The hospitalization time of the observation group was shorter than that of the control group,and the intraoperative blood loss was less than that of the control group,the VAS score at 2,12 h,and 24h after surgery was lower than that of the control group,the differences were statistically significant (P<0.05).The serum hs-CRP,IL-6,and cortisol levels in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion The single-hole thoracoscopic T3-4sympathetic nerve chain resection for the treatment of primary hand sweat reduces the hospitalization time,reduces the intraoperative blood loss,inflammatory factors and cortisol levels,and alleviates the pain of patients.It is worthy of clinical promotion and application.
2020 Vol. 27 (2): 46-48 [Abstract] ( 88 ) HTML (34 KB)  PDF  (0 KB)  ( 14 )
49 Clinical effect of Dexzopiclone combined with Flupentixol and Melitracen in the treatment of insomnia with depression and (or) anxiety
SHI Lin-juan； LI Hui-mian
Objective To investigate the clinical effect of Dexzopiclone combined with Flupentixol and Melitracen in the treatment of insomnia with depression and(or)anxiety.Methods A retrospective analysis was performed on 144 cases of insomnia with depression and (or) anxiety admitted to our hospital from January 2018 to January 2019 were selected as the study subjects.According to the different medication methods,they were divided into group A (n=46),group B (n=48),and group C (n=50).Group A was treated with Dexzopiclone,group B was treated with Flupentixol and Melitracen,and group C was treated with Dexzopiclone combined with Flupentixol and Melitracen.The scores of Pittsburgh sleep quality index (PSQI),Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) were compared among the three groups.The treatment emergent symptom scale (TESS) score and adverse reactions were compared among the three groups.Results The HAMD and HAMA scores of patients in group B and C after treatment were lower than those of group A,the differences were statistically significant (P<0.05).There was no significant difference in HAMD and HAMA scores between group B and group C (P>0.05).The PSQI score of group C after treatment was lower than that of group A and group B,the difference was statistically significant (P<0.05).There was no significant difference in TESS score and total incidence of adverse reactions among the three groups (P>0.05).Conclusion The patients of insomnia with depression and (or) anxiety were treated with Dexzopiclone Tablets combined with Flupentixol and Melitracen,the patients′ clinical anxiety and depression were significantly improved and well tolerated,worthy of clinical application.
2020 Vol. 27 (2): 49-51转55 [Abstract] ( 127 ) HTML (35 KB)  PDF  (0 KB)  ( 14 )
52 Clinical effect of Repaglinide combined with Metformin on the treatment of sulfonylurea secondary failure diabetes
WANG Xiao-xia
Objective To investigate the clinical effect of Repaglinide combined with Metformin on the treatment of sulfonylurea secondary failure diabetes.Methods Fifty patients with sulfonylurea secondary failure diabetes admitted to our hospital from May 2016 to May 2018 were enrolled as the study subjects.They were divided into control group(25 cases) and observation group (25 cases) according to random number table method.Patients in the control group were treated with Metformin on the basis of sulfonylureas,and patients in the observation group were treated with Repaglinide and Metformin.The blood glucose control effect and adverse reactions were compared between the two groups.Results There were no significant differences in the levels of fasting plasma glucose (FPG),blood sugar 2 hours after meal(2 h PG) and glycosylated hemoglobin (HbA1c) between the two groups before treatment (P>0.05).The FPG and 2 h PG levels in the two groups after treatment for 3,6,and 12 weeks were lower than those before treatment,with statistical significance (P<0.01).The HbA1c levels in the two groups after 6 and 12 weeks of treatment were lower than those before treatment,the differences were statistically significant (P<0.05).The levels of FPG and HbA1c in the observation group were lower than those in the control group after 6 and 12 weeks of treatment,the differences were statistically significant (P<0.05).The 2 h PG levels in the observation group were lower than those in the control group after 3,6,and 12 weeks of treatment,the differences were statistically significant (P<0.01 ).The insulin (INS) levels after treatment in both groups were lower than those before treatment,and the C-peptide (CP) levels were higher than those before treatment,the differences were statistically significant (P<0.05).The INS level of the patients in the observation group after treatment was lower than that in the control group,and the CP level was higher than that in the control group,the differences were statistically significant (P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant (P<0.05).Conclusion The combination of Repaglinide and Metformin on the treatment of sulfonylurea secondary failure diabetes patients has better blood sugar control effect and better adverse reaction improvement,which is worthy of promotion.
2020 Vol. 27 (2): 52-55 [Abstract] ( 98 ) HTML (34 KB)  PDF  (0 KB)  ( 10 )
56 Correlation analysis of hyperthyroidism and serum uric acid
QIN Yu-jun
Objective To analyze the correlation of hyperthyroidism and serum uric acid (SUA).Methods A total of 100 patients with hyperthyroidism admitted to our hospital from June 2017 to August 2018 were selected as observation group (50 patients with normal SUA and 50 patients with high SUA),and 100 healthy medical personnel were selected at the same time as control group,the thyroid function indexes and SUA levels were measured in both groups,and the levels of the indicators in the two groups were compared.Results The free of triiodothyronine (FT3) was (24.34±1.09)pmol/L,free thyroxine (FT4) was (64.33±1.92) pmol/L,SUA was (309.45±2.12) μmol /L in the observation group,which were higher than (4.43±1.98) pmol/L,(17.45±2.01) pmol/L,(278.34±2.01) μmol/L in the control group;the thyroid stimulating hormone (TSH) was (0.14±0.01) μIU/ml in the observation group,which was lower than (2.55±0.12) μIU/ml in the control group,the differences were statistically significant (P<0.05).The serum total triiodothyronine (TT3),total thyroxine (TT4),FT3,FT4,thyroglobulin antibody (TgAb),TSH receptor antibody (TRAb) in high SUA population are higher than those in normal SUA population,TSH and thyroid peroxidase antibody (TPOAb) in high SUA population were lower than those in normal SUA population,with statistically significant differences (P<0.05).TT3and TT4were positively correlated with SUA levels (P＜0.05).Conclusion Hyperthyroidism has a certain correlation with SUA,and should be paid attention to clinically.
2020 Vol. 27 (2): 56-58 [Abstract] ( 114 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
59 Application effect of noninvasive real-time arterial blood pressure monitoring system in trigeminal nerve microvascular decompression surgery
ZENG Shu-qiong; ZHANG Chun-xia ; LI Xiu-qi

Objective To explore the application effect of noninvasive real-time arterial blood pressure monitoring system in trigeminal nerve microvascular decompression surgery.Methods A total of 100 patients with trigeminal nerve microvascular decompression surgery admitted to our hospital from February 2016 to February 2019 were selected as the study objects,they were divided into control group (n=50) and observation group (n=50) according to the random drawing method.The blood pressure of the control group was measured by routine blood pressure detector,and the observation group was monitored by noninvasive real-time arterial blood pressure monitoring system.Blood pressure before and after operation was compared between the two groups.The effect of operation and the total incidence of adverse reactions were compared between the two groups.Results There was no significant difference in systolic pressure(SBP) and diastolic pressure (DBP) between the two groups (P>0.05).The levels of SBP and DBP in the two groups were lower than those before operation at 10 minutes and after operation,the differences were statistically significant(P<0.05).The levels of SBP and DBP in the observation group were higher than those in the control group at 10 minutes after operation and after operation,the differences were statistically significant (P<0.05).There was no significant difference of total effective rate of surgical treatmentbetween the two groups (P>0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant (P<0.05).Conclusion For patients undergoing trigeminal microvascular decompression surgery,conventional blood pressure detector and noninvasive real-time arterial blood pressure monitoring system have the same effect on surgical treatment,but noninvasive real-time arterial blood pressure monitoring system can continuously monitor the blood pressure level of patients and reduce the incidence of complications,which is worthy of clinical application.
2020 Vol. 27 (2): 59-61 [Abstract] ( 90 ) HTML (31 KB)  PDF  (0 KB)  ( 14 )
62 Application effect of controlled low central venous pressure technique in laparoscopic hepatectomy
GAN Qin
Objective To investigate the effect of controlled low central venous pressure technique in laparoscopic hepatectomy.Methods A total of 100 patients undergoing laparoscopic hepatectomy in Department of Hepatobiliary and Pancreatic Surgery of our hospital from October 2014 to January 2019 were selected as the study subjects.They were randomly divided into control group and observation group,50 cases in each group.The patients in the control group underwent normal central venous pressure technique,and the patients in the observation group underwent controlled low central venous pressure technique.The surgical related indexes,liver and kidney function,and blood gas analysis indexes of the two groups were compared.Results The total amount of bleeding and intraoperative blood loss in the observation group were lower than those in the control group,and the liver cutting time was shorter than that in the control group,the differences were statistically significant (P<0.05).There were no significant differences in total bilirubin,serum creatinine,alanine aminotransferase and blood urea nitrogen levels between the two groups one day before surgery (P>0.05).At one day after surgery,total bilirubin and blood creatinine,alanine aminotransferase and blood urea nitrogen levels were higher than those one day before surgery,and which in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).At one day after operation,there were no significant differences in blood gas pH (pH) and oxygen saturation (SpO2) between the two groups (P>0.05).The oxygenpartial pressure (PaO2) and residual alkali (BE) of the observation group were lower than those of the control group,and the bicarbonate (HCO3-) was higher than that of the control group,the differences were statistically significant (P<0.05).Conclusion Controlled low central venous pressure technique can not only reduce the amount of bleeding,shorten the time of liver cutting,promote the recovery of liver and kidney function,but also reduce the influence on arterial blood gas index in laparoscopic hepatectomy.It is worthy of promotion in clinical practice.
2020 Vol. 27 (2): 62-64 [Abstract] ( 92 ) HTML (35 KB)  PDF  (0 KB)  ( 11 )
65 Effect of ultrasonic knife combined with peel bridge lateral transfer in the treatment of circumferential mixed hemorrhoid
LIU Yi-wu
Objective To evaluate the curative effect of ultrasonic knife and peel bridge lateral transfer in the treatment of circumferential mixed hemorrhoids.Methods Ninety patients with circumferential mixed hemorrhoids in our hospital from July 2016 to February 2019 were selected,and they were divided into control group (traditional external dissection and internal ligation,45 cases) and observation group (ultrasonic knife combined with peel bridge lateral transfer,45 cases) according to random number table method.The clinical efficacy,operation time,intraoperative bleeding volume,healing time and complications were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant (P<0.05).There was no significant difference in operation time between the two groups (P>0.05),the amount of bleeding in the observation group was less than that in the control group,and the healing time was shorter than that in the control group,the differences were statistically significant (P<0.05).The incidences of anal stenosis,pain,perianal edema,dysuria and external hemorrhoids in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion Ultrasound scalpel combined with peel bridge lateral transfer in the treatment of circular mixed hemorrhoid has definite curative effect,and can also promote the recovery after operation and reduce the occurrence of complications after operation.
2020 Vol. 27 (2): 65-67 [Abstract] ( 95 ) HTML (31 KB)  PDF  (0 KB)  ( 12 )
68 Clinical effect of laparoscopic hepatectomy in the treatment of intrahepatic bile duct stones
YUAN Yang-chun； LI Mu-ran ； XIE Tian ； LUO Yu-qing
Objective To study the clinical effect of laparoscopic hepatectomy in the treatment of intrahepatic bile duct stones.Methods A total of 110 patients with intrahepatic bile duct stones admitted to our hospital from April 2015 to April 2019 were selected as the research objects.According to the computer random method,they were divided into observation group and control group,55 cases in each group.Laparoscopic hepatectomy was performed in the observation group and laparotomy was performed in the control group.The intraoperative and postoperative conditions and complications were compared between the two groups.Results The operation time of the patients with intrahepatic bile duct stones in the observation group was longer than that in the control group,and the amount of bleeding during the operation was less than that in the control group,the differences were statistically significant (P<0.05).The analgesic,feeding time,first time out of bed and hospitalization time of patients with intrahepatic bile duct stones in the observation group were shorter than those in the control group,and the differences were statistically significant (P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant (P<0.05).Conclusion Laparoscopic hepatectomy for intrahepatic bile duct stones is effective and safe,which is worth studying.
2020 Vol. 27 (2): 68-70 [Abstract] ( 85 ) HTML (31 KB)  PDF  (0 KB)  ( 13 )
71 Clinical effect of laparoscopic repairing combined with highly selective vagotomy for duodenal ulcer perforation
ZOU Yong; GONG Zhao-hua; YE Bo-jian; LUO Jie-bo
Objective To investigate the value of laparoscopic repairing combined with highly selective vagotomy in the treatment of duodenal ulcer perforation.Methods From January 2014 to January 2018,60 patients with duodenal ulcer perforation admitted to our hospital were selected as the study subjects.They were divided into the control group (n=30) and observation group (n=30) using odds or even number method.In the control group,laparoscopic repairing was used,while in the observation group,on the basis of the control group,highly selective vagotomy was added.The clinical efficacy,surgical related indexes and complications were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group with significant difference (P<0.05).There were no significant differences in the operation time and intraoperative blood loss between the observation group and the control group (P>0.05).The maximum acid output one year after operation was lower than that in the control group with significant difference (P<0.05).The hospital stay time in the observation group was shorter than that in the control group,and the difference was statistically significant (P<0.05).The total incidence of complications in the observation group was lower compared with that in the control group,and the difference was statistically significant (P<0.05).Conclusion Laparoscopic repairing combined with highly selective vagotomy for the treatment of duodenal ulcer perforation is effective by shortening hospital stay time,reducing maximum acid output and alleviating complications.
2020 Vol. 27 (2): 71-73 [Abstract] ( 101 ) HTML (31 KB)  PDF  (0 KB)  ( 13 )
74 Applaction effect comparison of different internal fixation methods in patients with multiple rib fractures
LIANG Lei; WANG Ze-xue
Objective To compare the applaction effect of different internal fixation methods in the treatment of multiple rib fractures.Methods A total of 200 patients with multiple rib fractures admitted to our hospital from March 2017 to February 2019 were selected as research objects,and were divided into observation group and control group according to the principle of segmental randomization,with 100 cases in each group.Patients in the control group were internally fixed with nickel-titanium embracing fixator,while patients in the observation group were internally fixed with rib locking titanium plate.The visual analogue scale (VAS) scores,intraoperative blood loss,postoperative hospital stay and complications of the two groups were compared before treatment and 24 and 48 h after treatment.Results At 24 and 48 h after treatment,the VAS scores of the patients in the observation group were lower than those in the control group,and the amount of intraoperative hemorrhage was less than that in the control group,and the total incidence rate of complications was lower than that in the control group,the differences were statistically significant (P<0.05).There was no significant difference in hospital stay between the two groups (P>0.05).Conclusion Compared with nickel-titanium embracing fixator internal fixation,rib locking titanium plate internal fixation applied in patients with multiple rib fractures can significantly relieve patient pain,reduce intraoperative blood loss,shorten hospitalization time and reduce the incidence of postoperative complications,which is worthy of clinical application and promotion.
2020 Vol. 27 (2): 74-77 [Abstract] ( 97 ) HTML (36 KB)  PDF  (0 KB)  ( 14 )
78 Clinical effect of arthroscopic treatment of shoulder dislocation combined with fracture of greater tubercle of humerus
GUO Jiu-sheng; HUANG Xiao-hua; GUAN Zhen-hua
Objective To explore the clinical effect of arthroscopic treatment of shoulder dislocation combined with fracture of greater tubercle of humerus.Methods The clinical data of 46 patients with shoulder dislocation combined with fracture of greater tubercle of humerus from April 2017 to April 2018 were analyzed retrospectively,the patients were divided into participating group and the research group by balanced grouping method,with 23 cases in each group.The participating group treated with traditional methods,and the research group treated with arthroscope for surgery.The total effective rate,complication rate,visual analogue scale (VAS) score,Neer shoulder function score and joint activity of the two groups were compared.Results The total effective rate of the research group was 95.65%,which was higher than 65.22% of the participating group,the difference was statistically significant (P<0.05).The total incidence of complications in the research group was 4.35%,which was lower than 34.78% in the participation group,the difference was statistically significant (P<0.05).After treatment,the VAS score and joint activity score of the research group were lower than those of the participation group,and neer elbow function score was higher than that of the participation group,the differences were statistically significant (P<0.05).Conclusion Arthroscopic treatment of shoulder dislocation combined with fracture of greater tubercle of humerus can improve the treatment effect of patients,reduce the incidence of complications of patients,relieve the pain of patients,improve the elbow joint function and activity of patients,which is worthy of clinical application and promotion.
2020 Vol. 27 (2): 78-80 [Abstract] ( 82 ) HTML (30 KB)  PDF  (0 KB)  ( 14 )
81 Effect of Gemcitabine combined with Erlotinib in the treatment of advanced pancreatic cancer
WANG Min; ZHAO Jian-hua
Objective To investigate the effect of Gemcitabine combined with Erlotinib in the treatment of advanced pancreatic cancer.Methods Forty patients with advanced pancreatic cancer admitted to our hospital from January 2017 to January 2018 were selected as the research objects for retrospective analysis.They were divided into control group(20 cases) and observation group (20 cases) according to different treatment methods.Patients in the observation group were treated with Gemcitabine combined with Erlotinib,while patients in the control group were treated with Gemcitabine combined with Tegafur.The clinical therapeutic effects,clinical benefits (pain relief intensity ≥50%,analgesic drug dosage reduction ≥50%,weight gain >7%) and adverse reactions (leukopenia,thrombocytopenia,rash,nausea and vomiting,transaminase elevation) were compared between the two groups.Results The total effective rate of patients in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The total clinical benefit rate of patients in the observation group was higher than that in the control group,and the difference was statistically significant (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion After Gemcitabine combined with Erlotinib is adopted for advanced pancreatic cancer patients,the total treatment efficiency and clinical total benefit rate of the patients are improved,the incidence rate of adverse reactions of the patients is not increased,and the method has higher clinical application value.
2020 Vol. 27 (2): 81-83 [Abstract] ( 107 ) HTML (32 KB)  PDF  (0 KB)  ( 18 )
84 Effect comparison of minimally invasive laparoscopic and traditional open hepatectomy in the treatment of liver cancer
HUANG Xue-kai
Objective To compare the clinical effect of hepatectomy for liver cancer using minimally invasive laparoscopy and laparoscopy.Methods A total of 50 patients with liver cancer who had surgical indications admitted to our hospital from March 3,2017 to March 3,2018 were selected as the subjects.They were divided into the experimental group and the control group according to their willing,with 25 cases in each group.In the experimental group,minimally invasive laparoscopic hepatectomy was adopted for lump removal in liver cancer patients,and in the control group,traditional laparotomy for liver cancer resection was used.The operation time,intraoperative bleeding volume,operation recovery,changes of serological indexes before and after treatment,and the survival rate,recurrence rate and metastasis rate in one year follow-up were compared between the two groups.Results There was no significant difference in operation time between the two groups (P>0.05).The feeding time,drainage tube retention time and hospitalization time of patients in the experimental group were shorter than those in the control group,the amount of intraoperative bleeding was less than that in the control group,and the postoperative pain score was lower than that in the control group,the differences were statistically significant (P<0.05).After treatment,the levels of alanine aminotransferase (ALT),aspartate aminotransferase (AST),procalcitonin (PCT) in the experimental group were lower than those in the control group,and the albumin (ALB) level was higher than that in the control group,the differences were statistically significant (P<0.05).The levels of ALT,AST and PCT in the two groups after treatment were higher than those before treatment,and the ALB level was lower than that before treatment,the differences were statistically significant(P<0.05).Follow up for 1 years,there was no significant difference in the survival rate,recurrence rate or metastasis rate between the two groups (P>0.05).Conclusion For liver cancer patients with surgical indications,compared with traditional laparotomy for hepatectomy,minimally invasive laparoscopic surgery can reduce intraoperative amount of bleeding,reduce the postoperative pain score,promote postoperative recovery,and relieve liver injury,which is worthy of popularization and application.
2020 Vol. 27 (2): 84-86转90 [Abstract] ( 100 ) HTML (33 KB)  PDF  (0 KB)  ( 12 )
87 Clinical effect of Amifostine combined with Gemcitabine and Cisplatin in the treatment of advanced breast cancer
MU Ya-nan
Objective To investigate the clinical effect of Amifostine combined with Gemcitabine and Cisplatin in the treatment of advanced breast cancer.Methods A total of 140 patients with advanced breast cancer treated in the First Affiliated Hospital,School of Medicine,Shihezi University from May 2014 to June 2016 were selected as the study subjects.They were divided into experimental group and reference group by random number table method,with 70 cases in each group.The control group was treated with Gemcitabine and Cisplatin,and the experimental group was treated with Amifostine.The total effective rate,the total incidence of adverse reactions,the survival time and the 1-year and 2-year expected survival rates of the two groups were compared,and the pain of the two groups before and after treatment was observed.Results The total effective rate of the experimental group (71.43%) was higher than that of the reference group (58.57%),and the difference was statistically significant (P<0.05).The total incidence of adverse reactions in the experimental group (14.29%) was lower than that in the reference group (25.71%),and the difference was statistically significant (P<0.05).The survival time of the experimental group was longer than that of the reference group,and the 1-year and 2-year expected overall survival rate was higher than that of the reference group,the differences were statistically significant (P<0.05).After treatment,the pain score of the experimental group was lower than that of the reference group,the difference was statistically significant (P<0.05).The pain scores of the two groups after treatment was lower than those before treatment,the differences were statistically significant (P<0.05).Conclusion For patients with advanced breast cancer,Amifostine combined with Gemcitabine and Cisplatin can improve the therapeutic effect and reduce the total incidence of adverse reactions,which is worthy of promotion and application.
2020 Vol. 27 (2): 87-90 [Abstract] ( 72 ) HTML (36 KB)  PDF  (0 KB)  ( 10 )
91 Effect of cervical ring electrotomy on the treatment of cervical precancerous lesions
HUANG Chao
Objective To explore the effect of cervical ring electrotomy on the treatment of cervical precancerous lesions.Methods A total of 76 patients with cervical precancerous lesions who were admitted to our hospital from February 2013 to February 2018 were enrolled in the study.They were divided into control group and observation group according to the order of admission,38 cases in each group.The control group was given routine surgery and the observation group was given cervical ring electrotomy.Perioperative indicators,treatment outcomes,incidence of complications,and recurrence rates were compared between the two groups.Results The operation time,vaginal discharge duration,and hospitalization time of the observation group were shorter than those of the control group,and the intraoperative blood loss was less than that of the control group,the differences were statistically significant (P<0.05).The total effective rate of treatment in the observation group was 97.37%,which significantly higher than 86.84% of the control group,the difference was statistically significant (P<0.05).The overall incidence of complications in the observation group was 5.26%,the recurrence rate was 2.63%,which was lower than 23.68% and 15.79% of the control group,the differences were statistically significant (P<0.05).Conclusion The application of cervical ring electrotomy to cervical precancerous lesions has the advantages of small trauma,simple operation,excellent prognosis,high safety and extremely high clinical application and popularization value.
2020 Vol. 27 (2): 91-93 [Abstract] ( 75 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
94 Risk factors investigation of PICC-related upper extremity venous thrombosis in patients with tumor chemotherapy
HUANG Zeng-guang
Objective To analyze the risk factors of PICC-related venous thrombosis of upper extremities in patients with tumor chemotherapy.Methods A total of 200 cases of cancer patients treated with chemotherapy in our hospital from February 10,2015 to May 10,2016 were selected as the research objects.According to the occurrence of upper extremity venous thrombosis,they were divided into observation group (with upper extremity venous thrombosis) and control group (without upper extremity venous thrombosis),100 cases in each group.The influencing factors of two groups of patients were analyzed.Results There were significant differences in age,history of venous thrombosis,chronic renal insufficiency,anticoagulant drugs,time of chemotherapy and fluid replacement,D-Dimer (D-D) level before catheterization between the two groups (P<0.05);Logistic regression analysis showed that age >60 years old,history of venous thrombosis,chronic renal insufficiency,and increased D-D level before catheterization were risk factors for PICC-related upper extremity venous thrombosis (P<0.05).Conclusion The risk factors for PICC-related upper extremity venous thrombosis in tumor chemotherapy patients are age >60 years old,history of venous thrombosis,chronic renal insufficiency,and increased D-D level before catheterization,to prevention and treatment measures for these factors can significantly reduce the incidence of venous thrombosis and ensure patient safety.
2020 Vol. 27 (2): 94-96 [Abstract] ( 82 ) HTML (28 KB)  PDF  (0 KB)  ( 13 )
97 Effect comparison of Magnesium Sulfate combined with Nimodipine and Labetalol respectively in the treament of preeclampsia
LI Na； LI Fan-qing； QU Si-rao； ZHAO Man-man
Objective To observe the effect of Magnesium Sulfate combined with Nimodipine and Labetalol respectively in the treament of preeclampsia.Methods A total of 100 patients with preeclampsia admitted to our hospital from March 2015 to March 2018 were selected and divided into group A and group B using random number table method,50 cases in each group.Group A was treated with Magnesium Sulfate combined with Nimodipine,while group B was treated with Magnesium Sulfate combined with Labetalol.The curative effect，blood pressure and 24h urine protein changes before and after treatment in the two groups were observed.The levels of serum leukemia inhibitory factor (LIF) and Cystatin-C (Cys-C) before and after treatment in the two groups were compared.The pregnancy outcome and neonatal Apgar score of the two groups were observed.Results The total effective rate (94.00%) in group B was higher than that in the group A (80.00%),with statistical difference (P<0.05).After treatment,systolic blood pressure,diastolic blood pressure and 24h urine protein levels in both groups were lower than those before treatment,while after treatment,systolic blood pressure,diastolic blood pressure and 24h urine protein levels in group B were lower than those in group A,the differences were statistically significant (P<0.05).After treatment,the level of serum LIF in the two groups was higher than that before treatment,the level of Cys-C was lower than that before treatment,the level of LIF in group B was higher than that in group A,and the level of Cys-C was lower than that in group A,the differences were statistically significant (P<0.05).Apgar score neonatal in group B was higher than that in group A,the difference was statistically significant (P<0.05).Conclusion Magnesium Sulfate combined with Labetalol has better therapeutic effect,it can effectively reduce blood pressure and 24h urine protein level,improve serum LIF,Cys-C level and neonatal Apgar score.
2020 Vol. 27 (2): 97-99转109 [Abstract] ( 102 ) HTML (35 KB)  PDF  (0 KB)  ( 14 )
100 Application effect of Ergometrine combined with Oxytocin in cesarean section of scarred uterus
FANG Li-mei; KE Ying; LIU Gui-rong
Objective To analyze the application effect of Ergometrine combined with Oxytocin in cesarean section of scarred uterus.Methods A total of 72 parturients with scar uterine cesarean section treated in our hospital from January 2018 to January 2019 were selected as the subjects,and divided into group A and group B by double-blind method,with 36 cases in each group.Group A was treated with Oxytocin alone,and group B was treated with Ergometrine combined with Oxytocin.The amount of bleeding,diastolic blood pressure,systolic blood pressure,total incidence of adverse reactions were observed in the two groups.Results The amount of bleeding in group B was less than that in group A after 2 and 24hours administration,and the differences were statistically significant (P<0.05).The diastolic pressure ([65±4] mmHg) and systolic pressure ([110±10] mmHg) of group B were lower than those of group A([68±7],[117±13] mmHg),with statistically significant differences (P<0.05).The incidence of adverse reactions in group B was 5.5%,lower than 33.3% in group A,and the difference was statistically significant (P<0.05).Conclusion In order to avoid postpartum hemorrhage of scarred uterus,Ergometrine combined with Oxytocin should be adopted to improve the treatment effect of patients and reduce the incidence of adverse reactions.
2020 Vol. 27 (2): 100-102 [Abstract] ( 84 ) HTML (34 KB)  PDF  (0 KB)  ( 15 )
103 Relationship between vaginal microecosystem and high-risk Human Papillomavirus infection or cervical lesions
LI Juan； TIAN Tian； XIE Gui-fang ； FENG Yong-bo
Objective To investigate the correlation between vaginal microecosystem and high-risk Human Papillomavirus (HPV) infection and cervical lesions.Methods A total of 300 women who were screened for cervical cancer in our hospital from August 2016 to December 2018 were selected as the subjects.All subjects were examined for vaginal microecosystem,cervical liquid-based cytology,and high-risk HPV.The detection of Lactobacillus,cleanliness grading,high-risk HPV infection,and cervical lesions were observed and statistically analyzed.Results In the subjects,194 participants (64.7%) were detected with large/medium amount of Lactobacillus,and 106 cases (35.3%) with less/no Lactobacillus.The vaginal cleanliness Ⅰ-Ⅱwas 252 cases (84.0%),and the remaining 48 cases (16.0%) were in Ⅲ-Ⅳ.A total of 78 cases (26.0%) with high-risk HPV infection,and 222 cases (74.0%) without high-risk HPV infection.There were 64 cases (21.3%) with cervical lesions,and 236 cases (78.7%) with normal cervix.The positive rate of bacterial infection (BV),Monilial infection,and Trichomonas infection were 10.7%,13.0% and 0.6%,respectively.The proportion of Lactobacilli less/no,vaginal cleanliness Ⅲ-Ⅳ,and Monilial infection positive in cervical lesions were higher than those in cervical normal cases,the differences were statistically significant (P<0.05).There was no significant difference in BV and Trichomonad positive rates between patients with cervical lesions and those with normal cervix (P>0.05).Conclusion Lactobacillus is beneficial to maintain vaginal micro-ecological balance.Poor cleanliness combined with Monilial infection will increase the risk of high-risk HPV infection and cervical lesions.
2020 Vol. 27 (2): 103-105转113 [Abstract] ( 78 ) HTML (33 KB)  PDF  (0 KB)  ( 15 )
106 Clinical effect of inserting balloon+ring+anti-adhesion membrane after transcervial resection of intrauterine adhesion
XIAO Qian
Objective To investigate the clinical effect of inserting balloon+ring+anti-adhesion membrane after transcervial resection of intrauterine adhesion.Methods A total of 50 cases of patients with intrauterine adhesion admitted to our hospital from January to December 2018 were selected as the study objects,and they were randomly divided into observation group and control group,with 25 cases in each group.Both groups were treated with transcervial resection of intrauterine adhesion,the control group was treated with postoperative intrauterine balloon implantation,and the observation group was treated with inserting balloon+ring+anti-adhesion membrane.The clinical efficacy and uterine cavity morphology of the two groups were compared,the menstrual volume,increased menstrual volume,less menstrual volume and amenorrhea rate were counted,and the occurrence of adverse reactions of the two groups were recorded.Results The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant (P<0.05).The normal rate of uterine cavity morphology in the observation group was higher than that in the control group,the basic normal rate and the rate of re-adhesion were lower than those in the control group (P<0.05).The observation group had more menstrual volume than the control group,the increased rate of menstrual volume was higher than the control group,the less menstrual volume and amenorrhea rate were lower than the control group,the differences were statistically significant (P<0.05).No adverse reactions such as infection,fever,uterine perforation,and incarcerated IUD were found in the two groups.Conclusion In the treatment of intrauterine adhesion of inserting balloon+ring+anti-adhesion membrane after transcervial resection of intrauterine adhesion can effectively improve the surgical effect,restore the uterine cavity shape,reduce the rate of re-adhesion,improve the menstrual situation,and has a higher safety,with positive clinical significance.
2020 Vol. 27 (2): 106-109 [Abstract] ( 101 ) HTML (34 KB)  PDF  (0 KB)  ( 12 )
110 Effect comparison of different methods in the treatment of ovarian cancer and their impact on patients′ quality of life
LAI Ying
Objective To compare the effect of different methods in the treatment of ovarian cancer and their impact on patients′ quality of life.Methods A total of 58 patients with ovarian cancer from January 2015 to Octorber 2017 were selected as the subjects,and divided as the experimental group and control group by random number table method,with 29 cases in each group.The experimental group was treated with preopearative Paclitaxel+Carboplatin (TC)chemotherapy+cytoreductive surgery+peritoneal TC thermofusion+postoperative conventional chemotherapy,and the control group recerived cytoreductive surgery+postoperative routine chemotherapy.The operation condition,treatment effect,quality of life score,complications,recurrence rate and mortality of the two groups were compared.Results The operation time and hospitalization time of the experimental group were shorter than those in the control group,and the differences were statistically significant (P<0.05).The amount of blood loss ([425.29±142.73] ml) and ascites([670.35±163.87] ml) in the experimental group were less than those in the control group ([801.62±125.26],[893.40±164.38] ml),and the differences were statistically significant (P<0.05).The total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant (P<0.05).There was no significant difference in the quality of life scores between the two groups before treatment (P>0.05).The scores of emotional function and total health status in the experimental group were higher than those before treatment and the control group,while the scores of pain,fatigue,constipation and shortness of breath in the experimental group were lower than those before treatment and the control group,and the differences were statistically significant (P<0.05).The scores of pain and fatigue in the control group were lower than before treatment,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications between the two groups (P>0.05).The recurrence rate and mortality rate of the experimental group were lower than those of the control group,and the differences were statistically significant (P<0.05).Conclusion For patients with ovarian cancer,preopearative TC chemotherapy+cytoreductive surgery+peritoneal TC thermofusion+postoperative conventional chemotherapy has better curative effect than tumor cytoreductive surgery+postoperative conventional chemotherapy,which can be widely used in clinic.
2020 Vol. 27 (2): 110-113 [Abstract] ( 80 ) HTML (36 KB)  PDF  (0 KB)  ( 13 )
114 Effect of repeated cesarean section on secondary pregnant women with scarred uterus and the newborns
YIN Jun
Objective To investigate the effect of repeated cesarean section on secondary pregnant women with scarred uterus and the newborns.Methods The clinical data of 130 pregnant women with cesarean section admitted to our hospital from January 2017 to June 2018 were retrospectively analyzed.A total of 65 cases of non-scarred uterus with cesarean section were selected as control group,and 65 cases of scarred uterus with repeated cesarean section were taken as observation group.The operation time,duration of lochia and hospital stays were compared between the two groups.The maternal bleeding volume,postoperative complications and neonatal outcome in the two groups were observed.Results The operation time,duration of lochia and hospital stays in the observation group were longer than those in the control group,the intraoperative and postoperative bleeding volume in the observation group were more than those in the control group,and the differences were statistically significant (P<0.05).The total incidence of hysterectomy,placenta accreta and postpartum hemorrhage in observation group was higher than that in the control group,and the difference was statistically significant (P<0.05).The rate of neonatal asphyxia in the observation group was higher than that in the control group,while the Apgar scores of newborns in the observation group were lower than those in the control group,and the differences were statistically significant (P<0.05).There was no statistical difference in the neonatal weight between the two groups (P>0.05).Conclusion The scar uterus with repeated cesarean section has higher risk and more postoperative complications,and it has a greater impact on mother and fetus.Clinically,it is necessary to strictly control cesarean section indexes,so as to reduce the incidence of scar uterus with repeated cesarean section.
2020 Vol. 27 (2): 114-116 [Abstract] ( 78 ) HTML (32 KB)  PDF  (0 KB)  ( 11 )
117 Clinical effect of pelvic floor rehabilitation therapy instrument combined with pelvic floor muscle exercise on female pelvic floor dysfunction
CHEN Xin-ming； BA Jing； DENG Ying-ying
Objective To explore the clinical effect of pelvic floor rehabilitation therapy instrument combined with pelvic floor muscle exercise on female pelvic floor dysfunction.Methods From September 2017 to January 2019,62 cases of female pelvic floor dysfunction patients admitted to our hospital were selected as research objects,and they were divided into control group(30 cases)and observation group(32 cases)according to the random number table method.Patients in the control group were given pelvic floor muscle exercise,while patients in the observation group were given pelvic floor rehabilitation therapy instrument combined with pelvic floor muscle exercise.The clinical efficacy,pelvic floor muscle strength and quality of life between the two groups were compared.Results The total effective rate of patients in the observation group was 93.75%,which was higher than 73.33% in the control group,and the difference was statistically significant (P<0.05).After treatment,the pelvic floor muscle strength score,pelvic floor class I and Ⅱmuscle fiber muscle voltage of patients in the observation group were higher than those in the control group,and the fatigue degree of pelvic floor class I and Ⅱmuscle fiber were lower than those in the control group,the differences were statistically significant (P<0.05).The scores of psychosis,somatization compulsion,hostility,interpersonal relationship and paranoid ideation in the observation group were lower than those in the control group,and the differences were statistically significant (P<0.05).Conclusion Pelvic floor rehabilitation therapy instrument combined with pelvic floor muscle exercise can improve the quality of life of female patients with pelvic floor dysfunction,promote pelvic floor muscle recovery,and has good clinical effect.
2020 Vol. 27 (2): 117-119转123 [Abstract] ( 87 ) HTML (35 KB)  PDF  (0 KB)  ( 9 )
120 Application value of four-dimensional hysterosalpingocontrast sonography in diagnosis of tubal patency and diseased region
ZENG Wen
Objective To investigate the clinical value of four-dimensional hysterosalpingocontrast sonography in diagnosis of tubal patency and diseased region.Methods The clinical data of 121 female patients with four-dimensional hysterosalpingocontrast sonography in our hospital from October 2016 to October 2018 were retrospectively analyzed.They were given laparoscopic Methylene Blue hydrotubation after radiography for 4 weeks.The diagnostic results,diagnostic efficiency and diseased region were analyzed.Results The diagnostic results of laparoscopic Methylene Blue hydrotubation were taken as the gold standard,the diagnostic accordance rate of four-dimensional hysterosalpingocontrast sonography in tubal patency was 86.79%,the proportion of partial obstruction was 58.33%,the proportion of complete obstruction was 81.48%,and the total diagnostic accordance rate was 80.27%.The diagnostic sensitivity,specificity,positive predictive value,negative predictive value of four-dimensional hysterosalpingocontrast sonography in oviduct obstruction were 81.48%,88.03%,79.52%,89.29%,respectively.The fimbria lesions accounted for the highest proportion in patients with partial obstruction and complete obstruction,which were 27.27% and 32.61%,respectively.Conclusion Four-dimensional hysterosalpingocontrast sonography is an effective method for clinical diagnosis of female tubal patency,it can determine the location of the lesion,which is helpful for providing reference for the design of clinical follow-up treatment plan.
2020 Vol. 27 (2): 120-123 [Abstract] ( 83 ) HTML (33 KB)  PDF  (0 KB)  ( 10 )
124 Application effect of uterine compression suture combined with uterine artery ascending branch ligation in cesarean section of placenta previa
CHEN Sui-rong
Objective To investigate the application effect of uterine compression suture（UCS）combined with uterine artery ascending branch ligation in cesarean section of placenta previa.Methods A total of 54 pregnant women with placenta previa were selected in our hospital from January 2017 to February 2018.According to random number table method,they were divided into the control group and the observation group,27 cases in each group.The control group was given UCS to stop bleeding,and the observation group was combined with the uterine artery ascending branch ligation to stop bleeding.The intraoperative conditions,postoperative blood loss,hemostasis and postpartum hemorrhage were compared.Results The intraoperative blood loss of the observation group was lower than that of the control group,the blood transfusion rate was lower than that of the control group,the operation time was shorter than that of the control group,the differences were statistically significant (P<0.05).The bleeding volume at 2,12 and 24hours after operation in the observation group was lower than that in the control group,the differences were statistically significant (P<0.05).The total hemostatic effeciency of the observation group (96.30%) was higher than that of the control group(77.78%),the difference was statistically significant (P<0.05).The total incidence of postpartum complications in the observation group was lower than that of the control group,the difference was statistically significant (P<0.05).Conclusion For the placenta previa,combined use of UCS and uterine artery ascending branch ligation has better hemostasis effect,which can significantly prevent postpartum hemorrhage and reduce the risk of postoperative complications.
2020 Vol. 27 (2): 124-126 [Abstract] ( 77 ) HTML (33 KB)  PDF  (0 KB)  ( 14 )
127 Clinical effect of laparoscopic uterine artery ligation in the treatment of cesarean scar pregnancy
CHEN Mei-rong
Objective To investigate the clinical effect of laparoscopic uterine artery ligation in the treatment of cesarean scar pregnancy.Methods From December 2017 to December 2018,80 patients with uterine scar pregnancy after cesarean section admitted to our hospital were selected as the research objects,and the patients were randomly divided into control group and observation group according to odd even method,with 40 cases in each group.Patients in the control group were treated with Methotrexate and curettage,patients in the observation group were treated with Methotrexate and laparoscopic uterine artery ligation.The therapeutic effects and related surgical indexes of the patients between the two groups were compared.Results The total effective rate of patients in the observation group was 97.5%,compared with 87.5% in the control group,the difference was not statistically significant (P>0.05).The intraoperative blood loss of the patients in the observation group was less than that of the control group,and the hospitalization and menstruation recovery time were shorter than those of the control group,the differences were statistically significant(P<0.05).Conclusion Laparoscopic ligation of uterine artery for scar pregnancy can effectively reduce the amount of bleeding during operation,improve the treatment effect,shorten the hospitalization time and menstrual cycle time,and is worthy of clinical application and promotion.
2020 Vol. 27 (2): 127-129 [Abstract] ( 80 ) HTML (30 KB)  PDF  (0 KB)  ( 12 )
130 Clinical effect of Oral Rehydration Salt Ⅲcombined with Racecadotril and Zinc Gluconate in the treatment of acute diarrhea in children
WANG Heng
Objective To investigate the clinical effect of Oral Rehydration Salt Ⅲcombined with Racecadotril and Zinc Gluconate in the treatment of acute diarrhea in children.Methods A total of 90 children with acute diarrhea admitted to our hospital from January 2018 to January 2019 were selected as the research objects and randomly divided into experimental group (45 cases) and control group (45 cases).The experimental group was treated with Oral Rehydration Salt Ⅲcombined with Racecadotril and Zinc Gluconate,while the control group was treated with Oral Rehydration Salt Ⅲ.The remission time of clinical symptoms and clinical therapeutic effects of the two groups of children were compared.Results The stool characteristics returned to normal and the stool frequency reduction time,diarrhea duration,fever reduction time,abdominal pain and vomiting relief time of the children in the experimental group were shorter than those in the control group,with statistically significant differences (P<0.05).The total effective rate of the experimental group was 95.6%,which was higher than 77.8% of the control group,and the difference was statistically significant (P<0.05).Conclusion Combined application of Oral Rehydration Salt Ⅲ,Racecadotril and Zinc Gluconate in the treatment of children with acute diarrhea can improve the total effective rate of treatment and shorten the remission time of clinical symptoms.
2020 Vol. 27 (2): 130-132 [Abstract] ( 69 ) HTML (32 KB)  PDF  (0 KB)  ( 16 )
133 Effect of labor management according to the time limit of new labor process on maternal and infant outcomes under painless labor
ZHANG Wei-qiang
Objective To explore the effect of labor management according to the time limit of new labor process on maternal and infant outcomes under painless labor.Methods A total of 210 cases of single term pregnant women who gave birth painlessly in our hospital from July 2017 to July 2018 were selected as the research objects,and divided into study group (105 cases) and reference group (105 cases) according to the admission number of the pregnant women.The study group adopted the time limit management of the new stage of labor under painless labor,while the reference group adopted the standard management of the traditional stage of labor.The delivery mode,duration of each stage of labor,pregnancy complications,occurrence of maternal complications,neonatal outcomes and clinical medical intervention were compared between the two groups.Results The natural delivery rate of the study group was higher than that of the reference group,the first stage of labor and the total stage of labor were longer than those of the reference group,and the total clinical medical intervention rate was lower than that of the reference group,and the differences were statistically significant (P<0.05).There were no significant difference between the two groups in the second stage of labor,the third stage of labor,the incidences of pregnancy complications,the incidences of maternal complications,neonatal outcomes (P>0.05).Conclusion The time limit management of the new stage of labor under painless delivery is implemented for single term pregnant women.Although the first stage of labor and the total stage of labor are slightly longer,it can improve the natural delivery rate,reduce medical intervention and ensure the life and health of mothers and infants.Therefore,it is recommended to apply and popularize it in clinical practice.
2020 Vol. 27 (2): 133-135 [Abstract] ( 72 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
136 Clinical effect of transcranial stimulation combined with language intervention in the treatment of language retardation in children with cerebral palsy
YANG Juan-zi ; LIU Qi-yun; LI Xia
Objective To explore the clinical effect of transcranial stimulation combined with language intervention in the treatment of language retardation in children with cerebral palsy.Methods From January 2017 to January 2019,64 cases of cerebral palsy children with language retardation admitted to the department of pediatric encephalopathy in our hospital were selected as the subjects,they were divided into reference group and study group by the random number table method,with 32 cases in each group.The children in the reference group were treated with systematic language training intervention,while the children in the study group were treated with transcranial stimulation on the basis of reference group.The treatment effect and speech rehabilitation of the two groups were compared.Results The total effective rate of treatment in the study group was higher than that in the reference group,and the difference was statistically significant (P<0.05).Before treatment,there were no significant differences in language comprehension quotient and language expression quotient scores between the two groups (P>0.05).After treatment,the scores of language comprehension and language expression quotient in the two groups were higher than those before treatment,and the differences were statistically significant (P<0.05).After treatment,The scores of language comprehension and language expression quotient in the study group were higher than those in the reference group,and the differences were statistically significant (P<0.05).Conclusion Transcranial stimulation combined with language intervention in the treatment of language retardation in children with cerebral palsy can improve the clinical treatment effect and promote the development of children′s language system,which is worthy of clinical popularization.
2020 Vol. 27 (2): 136-138 [Abstract] ( 78 ) HTML (33 KB)  PDF  (0 KB)  ( 15 )
139 Influence of early and late onset of severe preeclampsia on maternal and infant prognosis
WU Xiao-shuang; WEN Ying
Objective To investigate the influence of early and late onset of severe preeclampsia on maternal and infant prognosis.Methods A total of 156 patients with severe preeclampsia admitted to our hospital from June 2016 to June 2018 were enrolled as subjects,they were divided into early onset group (early onset severe preeclampsia,59 cases)and late onset group (late onset of severe preeclampsia,97 cases) according to their gestational age.Clinical data such as blood pressure level,duration of termination,treatment time,and the way of ending the delivery were collected,the incidence of complications and perinatal outcomes were compared between the two groups.Results The diastolic blood pressure and systolic blood pressure of the early onset group were higher than those of the late onset group,the duration of termination was shorter than that of the late onset group,the treatment time in the early onset group was longer than that of the late onset group,the way of ending the delivery was worse than that of the late onset group,the rate of therapeutic induction of labor was higher than that of the late onset group,the differences were statistically significant(P<0.05).The incidence rates of complications such as eclampsia,liver and kidney function injury,hypoproteinemia and placental abruption in the early onset group were higher than those in the late onset group,and the differences were statistically significant (P<0.05).In the early onset group,the incidence of fetal growth restriction,premature delivery,low birth weight,fetal asphyxia,and perinatal mortality were higher than those of the late onset group,the differences were statistically significant (P<0.05).Conclusion Compared with patients with late onset severe preeclampsia,patients with early onset severe preeclampsia have an early gestational age,a high incidence of complications,a poor perinatal outcome and a more serious condition.Therefore,clinical should strengthen the monitoring of blood pressure in pregnancy,to achieve early prevention,early detection,early intervention,in order to improve the prognosis of mother and child.
2020 Vol. 27 (2): 139-141 [Abstract] ( 68 ) HTML (32 KB)  PDF  (0 KB)  ( 13 )
142 Effect analysis of Racecadotril in adjuvant treatment of children with acute diarrhea
HUANG Zhuan-di
Objective To investigate the clinical effect of Racecadotril in the treatment of children with acute diarrhea.Methods Ninety-six children with acute diarrhea admitted to our hospital from April to October 2018 were selected as research objects and divided into control group and experimental group according to random number table method,48 cases in each group.On the basis of routine treatment,the control group was treated with Montmorillonite Powder and Bifidobacterium Quadruple Viable Tablets,while the experimental group was treated with Racecadotril on the basis of the control group for 5-7 days.After treatment,the clinical effects,clinical symptom grading and quantitative scores and clinical symptom improvement before and after treatment were compared between the two groups.Results The total effective rate of clinical treatment in the experimental group was higher than that in the control group,and the difference was statistically significant (P<0.05).Before treatment,there was no significant difference in clinical symptom grading and quantitative scores between the two groups (P>0.05).After treatment,the clinical symptom grading quantitative scores of the two groups of children were lower than those before treatment,and the anorexia,stool frequency and stool character scores of the experimental group were lower than those of the control group,with statistically significant differences (P<0.05).The fever reduction,vomiting cessation,abdominal pain and distension cessation,stool frequency return to normal and stool character return to normal time in the experimental group were shorter than those in the control group,the differences were statistically significant (P<0.05).Conclusion Racecadotril is effective in the treatment of children with acute diarrhea.which can effectively improve the clinical symptoms of children and shorten the treatment time,and is worthy of clinical promotion and application.
2020 Vol. 27 (2): 142-144 [Abstract] ( 71 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
145 Risk factors investigation of secondary malignant glaucoma after trabeculectomy for primary angle-closure glaucoma
WANG Xue-lin; CHANG Jia-tai; SU Wen-hua; HE Liang-fei
Objective To investigate the risk factors of secondary malignant glaucoma after trabeculectomy in patients with primary angle-closure glaucoma (PACG) in order to guide clinical practice.Methods The clinical data of 140 cases of patients with PACG (120 eyes) treated in the ophthalmology department of our hospital from June 2017 to December 2018 were retrospectively analyzed.According to whether secondary malignant glaucoma occurred,the patients were divided into observation group (n=60,60 eyes with secondary malignant glaucoma) and control group (n=80,60 eyes without secondary malignant glaucoma).The relevant data of the two groups of patients were compared,and the factors that might lead to secondary malignant glaucoma were recorded and analyzed.Results There were significant differences in age,axial length,lens thickness,preoperative intraocular pressure,anterior chamber depth and angle structure between the two groups (P<0.05).There were no significant differences in gender,education level,family income per capita,hypertension,diabetes mellitus and coronary heart disease between the two groups (P>0.05).Logistic regression analysis showed that age ≤60 years,high preoperative intraocular pressure,angle closed completely,axial length <22 mm,lens thickness <4.5 mm,and anterior chamber depth ＜2 mm were all risk factors for secondary malignant glaucoma after PACG trabeculectomy (OR>1,P<0.05).Conclusion Age,preoperative intraocular pressure,anterior chamber angle structure,axial length,lens thickness and anterior chamber depth all increase the risk of malignant glaucoma in patients with PACG.For patients with such risk factors,preoperative symptomatic treatment should be actively taken to reduce the risk of malignant glaucoma in patients after surgery and improve the prognosis of patients.
2020 Vol. 27 (2): 145-148 [Abstract] ( 78 ) HTML (32 KB)  PDF  (0 KB)  ( 14 )
149 Clinical application effect of orthodontic treatment combined with implant denture repair in the patients with dentognathic deformities and single tooth loss
ZHANG Xin-yu
Objective To investigate the clinical application effect of orthodontic treatment combined with implant denture repair in the patients with dentognathic deformities and single tooth loss.Methods From January 2016 to November 2017,156 patients with dentognathic deformities and single tooth loss treated in our hospital were enrolled as research objects in the study.According to the random number table method,they were divided into study group and control group,78 cases in each group.Patients in the study group were treated with orthodontic treatment combined with implant denture repair,while patients in the control group were treated with orthodontic treatment.The masticatory function of the two groups before and after treatment was compared and analyzed,and the therapeutic effect and complications of the two groups were compared.Results The excellent and good rate of treatment in the study group(89.74%) was higher than that in the control group (78.21%),and the difference was statistically significant (P<0.05).The total incidence of complications in the study group (6.41%) was lower than that in the control group (19.23%),and the difference was statistically significant (P<0.05).There was no significant difference in masticatory efficiency between the two groups before treatment (P>0.05).The masticatory efficiency in the study group after treatment ([92.55±6.65]%) was higher than that in the control group ([78.30±6.40]%),with statistical significance (P<0.05).There was no significant difference in bite force between the two groups before treatment (P>0.05).The bite force of the study group after treatment ([244.35±12.70] lbs) was higher than that of the control group ([122.60±13.50] lbs),and the difference was statistically significant (P<0.05).Conclusion The application of orthodontic treatment combined with implant denture repair in the treatment of patients with dentognathic deformities and single tooth loss can effectively improve the patients′ chewing function,significantly improve the clinical treatment effect,and the incidence of complications is low,and the safety of treatment is high.It is worthy of popularization and application.
2020 Vol. 27 (2): 149-151转155 [Abstract] ( 77 ) HTML (34 KB)  PDF  (0 KB)  ( 16 )
152 Clinical effect of different dental filling materials in the treatment of tooth wedge-shaped defect
LIU Liang YANG Shuo LI Can-hong MO Zhi-chen
Objective To explore the clinical effect of different dental filling materials in the treatment of tooth wedgeshaped defect.Methods Fifty patients with tooth wedge-shaped defect who underwent filling treatment in the Stomatology Department of Zengcheng Traditional Chinese Medicine Hospital of Guangzhou City from August 2016 to August 2018 were selected as the research objects,and they were divided into control group (n=25) and observation group (n=25) according to the different filling materials.The control group was filled with glass ion,and the observation group was filled with light curing composite resin.The total effective rate of treatment,functional score of filling material,total incidence rate of complications and total satisfaction were compared between the two groups of patients.Results The total effective rate of treatment (96%),total satisfaction (96%),and functional score of filling material ([89.54±7.65] points)of the observation group were higher than those of the control group (68%,68%,[67.92±4.63] points),and the differences were statistically significant (P<0.05).The total incidence rate of complications in the observation group (4%) was lower than that in the control group (24%),and the difference was statistically significant (P<0.05).Conclusion The clinical application effect of light curing composite resin for the treatment of tooth wedge-shaped defect is better,it can improve the effective rate of treatment and the satisfaction of patients,which is worthy of clinical application and promotion.
2020 Vol. 27 (2): 152-155 [Abstract] ( 63 ) HTML (36 KB)  PDF  (0 KB)  ( 14 )
156 Clinical effect of minimally invasive implantation repairing the elderly patients with the loss of free end of the posterior teeth
RONG Zhu-ping
Objective To investigate the clinical effect of minimally invasive implantation repairing the loss of free end of the posterior teeth in the elderly.Methods Sixty elderly patients with the loss of free end of the posterior teeth were enrolled in our hospital from January 2012 to December 2017 as the research objects,and they were randomly divided into conventional implant restoration group (30 cases) and minimally invasive implant restoration group (30 cases).Patients in the conventional implant restoration group adopt conventional implant restoration methods,while patients in the minimally invasive implant restoration group adopt minimally invasive implant restoration methods.The recovery pain (visual analogue scale [VAS]) score,operation time,health survey scale (SF-36) score before and after treatment,masticatory function score and total incidence of complications were compared between the two groups.Results Before treatment,there were no significant difference in SF-36 and masticatory function scores between the two groups (P>0.05).After treatment,the SF-36 and masticatory function scores of the two groups were higher than those before treatment,the differences were statistically significant (P<0.05).After treatment,SF-36 and masticatory function scores of patients in minimally invasive implant restoration group were higher than those in conventional implant restoration group,and the differences were statistically significant (P<0.05).VAS score of patients in minimally invasive implant restoration group was lower than that in conventional implant restoration group,and the operation time was shorter than that in conventional implant restoration group,with statistically significant differences (P<0.05).The total incidence of complications in minimally invasive implant restoration group was lower than that in conventional implant restoration group,and the difference was statistically significant (P<0.05).Conclusion Minimally invasive implantation repairing the elderly patients with the loss of free end of the posterior teeth can achieve better results,and can effectively reduce the pain of patients in repair,shorten the treatment time,improve the health level and chewing function of patients,and reduce the total incidence of complications.
2020 Vol. 27 (2): 156-158 [Abstract] ( 78 ) HTML (31 KB)  PDF  (0 KB)  ( 11 )
159 Application effect of Dexmedetomidine under general anesthesia in patients undergoing ovarian cancer staging surgery
DU Xue-jun
Objective To investigate the application effect of Dexmedetomidine under general anesthesia in patients undergoing ovarian cancer staging surgery.Methods Fifty patients with ovarian cancer treated in oncology department of our hospital from January 2017 to January 2019 were selected as the research subjects,and they were divided into the experimental group (n=25) and the control group (n=25) by the random double-blind method.Patients in the control group received saline intravenous intervention during staging surgery under general anesthesia,and patients in the experimental group received Dexmedetomidine.The levels of inflammatory factors and T lymphocyte subsets in the two groups of patients at 15 min induction of anesthesia,1 h after surgery,and 24h after surgery were analyzed.The incidence of adverse reactions of the two groups was compared.Results There were no significant differences in the levels of inflammatory factors at 15 min induction of anesthesia of patients between the two groups (P>0.05).The levels of inflammatory factors of the two groups at 1 h after surgery and 24h after surgery were higher than those at 15 min induction of anesthesia,and the differences were statistically significant (P<0.05).The levels of inflammatory factors in the experimental group at 1 h after surgery and 24h after surgery were higher than those in the control group,and the differences were statistically significant (P<0.05).There were no significant differences in the levels of T lymphocyte subsets at 15 min induction of anesthesia of patients between the two groups (P>0.05).The levels of CD3+,CD4+and CD4+/CD8+in the experimental group at 1 and 24h after surgery were higher than those in the control group,and the level of CD8+in the experimental group at 24h after surgery was higher than that in the control group,with statistically significant differences (P<0.05).The incidence rates of agitation and cough in the experimental group were lower than those in the control group,and the differences were statistically significant (P<0.05).Conclusion Dexmedetomidine intervention for patients undergoing staging ovarian cancer under general anesthesia can effectively reduce the level of inflammatory factors and reduce the degree of immune damage in patients,which is worth promoting.
2020 Vol. 27 (2): 159-162 [Abstract] ( 88 ) HTML (39 KB)  PDF  (0 KB)  ( 12 )
163 Application effect of different intubation methods in guiding double lumen endobronchial tube for the thoracic surgery anesthesia intubation in patients with predictable difficult airway
YU Pin-xian； LIN Li-juan； WANG Zhu
Objective To compare the application effect of different intubation methods in guiding double lumen endobronchial tube (DLT) for the thoracic surgery anesthesia intubation in patients with predictable difficult airway.Methods From March 2015 to December 2018,69 patients with predictable difficult airway before anesthesia for thoracic surgery in our hospital were selected as the study subjects.They were divided into group A (23 cases),group B (23 cases) and group C (23 cases) according to the random number table method,three groups of patients were respectively given direct laryngoscope,video laryngoscope,fiberoptic bronchoscopy for DLT intubation.The intubation time,the success rate of one-time intubation,the incidence of intraoperative hypoxemia,the intraoperative DLT translocation rate,and the incidence of postoperative complications after intubation in the three groups were compared.The hemodynamic parameters (mean arterial pressure [MAP],heart rate [HR]) in three groups of patients were recorded before anesthesia (T0),immediately after induction of anesthesia (T1),immediately after intubation (T2),1 minute after intubation(T3),and 5 minutes after intubation (T4).Results The intubation time in group C was shorter than that in group A and group B,and the difference was statistically significant (P<0.05).The success rate of one-time intubation in group C was higher than that in group A,and the difference was statistically significant (P<0.05).The incidence of intraoperative hypoxemia in group C was lower than that in group A,and the difference was statistically significant (P<0.05).The intraoperative DLT translocation rate in group C was lower than that in group A and group B,and the difference was statistically significant (P<0.05).The total incidence of postoperative complications in group C was lower than that in group A,with statistically significant difference (P<0.05).There were no significant differences in MAP and HR at T0and T1among the three groups (P>0.05).The MAP of patients in group C was lower than that in group A and group B at T2,T3,and T4,with statistically significant differences (P<0.05).The HR of group C was lower than that of group A and group B at T2,and the differences were statistically significant (P<0.05).There were no significant differences in HR at T3and T4among the three groups (P>0.05).Conclusion Application of fiberoptic bronchoscopy in guiding DLT for the thoracic surgery anesthesia intubation in patients with predictable difficult airway is safe and feasible,which has short intubation time,few complications after intubation,small hemodynamic fluctuation amplitude,accurate positioning,and low incidence of intraoperative hypoxemia,which is worthy of clinical promotion and application in thoracic surgery.
2020 Vol. 27 (2): 163-167转171 [Abstract] ( 62 ) HTML (54 KB)  PDF  (0 KB)  ( 11 )
168 Effect of Dexmedetomidine combined with Oxycodone on the waking period of patients undergoing gynecological tumor surgery under general anesthesia
DENG Shi-hui； WANG Kai-jun； WANG Jie
Objective To study and analyze the effect of Dexmedetomidine combined with Oxycodone on the waking period of patients undergoing gynecological tumor surgery under general anesthesia.Methods A total of 98 patients who underwent gynecological tumor surgery under general anesthesia in our hospital were selected as the research objects from January 2017 to January 2018,and they were divided into four groups according to the random number table method.Patients in group D (25 cases) were given Dexmedetomidine,patients in group O (24 cases) were given Oxycodone,patients in DO group (24 cases) were given Dexmedetomidine combined with Oxycodone,and patients in group C (25 cases) were given saline.The waking time,extubation time,visual analogue scale (VAS) score at 20 minutes after extubation,cough score and serum pituitary-target gland axis-related hormone (thyroid-stimulating hormone [TSH],cortisol [Cor]) levels were compared in the four groups.Results The waking time in the DO group was shorter than that in the other three groups,and the difference was statistically significant (P<0.05).The extubation time in the DO group was longer than that in the group C,and shorter than that in the group D and group O,with statistically significant differences (P<0.05).The VAS score of the patients in the DO group at 20 minutes after extubation was lower than that in the group D and group C,and the cough score was lower than that in the other three groups,with statistically significant differences (P<0.05).The serum levels of TSH and Cor of patients in the DO group were lower than those in the other three groups,and the differences were statistically significant (P<0.05).Conclusion For patients undergoing gynecological tumor surgery under general anesthesia,Dexmedetomidine combined with Oxycodone can significantly shorten the waking time and extubation time,reduce VAS and cough scores after extubation,and reduce the content of pituitary-target gland axis related hormones in serum.
2020 Vol. 27 (2): 168-171 [Abstract] ( 85 ) HTML (35 KB)  PDF  (0 KB)  ( 10 )
172 Application effect of different concentrations of Butorphanol in analgesia after cesarean section for pregnancy with uterine scar
CHEN Yong-hua； YE Li-xian； WANG Jie-ru
Objective To investigate the application effect of different concentrations of Butorphanol in analgesia after cesarean section for pregnancy with uterine scar.Methods A total of 480 pregnant women with uterine scar and cesarean section admitted to our hospital from January to December 2018 were selected as the research subjects.They were divided into three groups according to the random number table method,with 160 cases in each group.Intravenous controlled analgesia was selected.The analgesics in group A were Butorphanol 150 μg/kg,combined with Sufentanil 1 μg/kg and Tropisetron 10 mg,which were then diluted to 100 ml with normal saline,and the controlled analgesia background infusion was 2 ml/h,the automatic dosage was 2 ml and intermittent time was 15 minutes.The concentration of Butorphanol in group B was reduced to 100 μg/kg on the basis of group A.The analgesic was Butorphanol 200 μg/kg,combined with Tropisetron 10 mg in group C.The visual analogue scale(VAS)scores at 4,8,12,24h,and 48 h after surgery and incidence of adverse reactions of the three groups were observed and recorded.Results The VAS scores at 4,8,12,24h,and 48 h after surgery in group A were lower than those in group B and group C,and the differences were statistically significant (P<0.05).There were no significant differences in VAS scores between group B and group C within 48 hours after surgery (P>0.05).There was no significant difference in the total incidence of adverse reactions among the three groups (P>0.05).Conclusion Butorphinol at a dose of 150 μg/kg is safe and effective for analgesia after cesarean section in pregnancy with uterine scar,and it is worth promoting.
2020 Vol. 27 (2): 172-174 [Abstract] ( 95 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
175 Application effect of Remifentanil combined with Propofol in laparoscopic cholecystectomy
SONG Qiang
Objective To investigate the application effect of Remifentanil combined with Propofol in laparoscopic cholecystectomy.Methods A total of 100 patients undergoing laparoscopic cholecystectomy treated in our hospital from January 2018 to January 2019 were selected as the research subjects and randomly divided into the experimental group(n=50) and the control group (n=50) according to the double-blind method.The control group anesthetized with Fentanyl and Propofol,and the experimental group anesthetized with Remifentanil and Propofol.The hemodynamic index levels before and after anesthesia,anesthetic effects and adverse reactions were compared between the two groups.Results There were no significant differences in systolic blood pressure (SBP),mean arterial pressure (MAP),diastolic blood pressure (DBP),heart rate (HR),and blood oxygen saturation (SpO2) levels in the experimental group before and after anesthesia (P>0.05).The levels of SBP,DBP,HR and SpO2after anesthesia in the control group were lower than those of before anesthesia,and the levels of MAP was higher than that of before anesthesia,the differences were statistically significant (P＜0.05).The levels of SBP,DBP,HR,and SpO2in the experimental group after anesthesia were higher than those in the control group,and the levels of MAP was lower than that in the control group,the differences were statistically significant (P＜0.05).The tracheal tube removal time,awake time and spontaneous breathing time of the experimental group were shorter than those of the control group,the differences were statistically significant (P<0.05).The total incidence of adverse reactions in the experimental group (6.00%) was lower than that in the control group (20.00%),the difference was statistically significant (P<0.05).Conclusion Patients undergoing laparoscopic cholecystectomy receive Remifentanil and Propofol combined anesthesia,which can adjust the hemodynamic index level of the patient,shorten the tracheal catheter removal time,wake time and restore spontaneous breathing time,reduce the incidence of adverse reactions,which is worthy of clinical application.
2020 Vol. 27 (2): 175-177转182 [Abstract] ( 78 ) HTML (34 KB)  PDF  (0 KB)  ( 9 )
178 Study on the relationship between atmospheric pollutants and male sperm quality in Shenyang
LIANG Yue； YAN Xin-xin； ZHANG Jin-zhe； MA Hui-ping； GUO Ting-chao； ZHANG Qiang
Objective To study the relationship between the exposure of different atmospheric pollutants in four stages of sperm development and the decline of sperm quality of the man in Shenyang.Methods A randomized survey was conducted on 216 men patients from Liaoning Research Institute of Family Planning who underwent at least one semen examination from September 23 to December 16,2016.According to the semen parameter reference limits of WHO Semen Examination and Processing Laboratory Manual,the study subjects were divided into normal group and decreased group among parameters.The data were strictly screened,statistical methods was used to organize entries and establish databases.Independent-sample t-test,rank sum test,and binary Logistic regression analysis were used to evaluate the relationship between atmospheric pollutants from 0-90 days before semen examination,0-9 days before semen examination,10-14 days before semen examination ,70-90 days before semen examination and sperm motility,forward motile sperm,sperm concentration and sperm count.Results At 0-90 days and 70-90 days before semen collection,CO exposure concentration had a significant effect on sperm concentration and total sperm count,and the difference between normal group and decreased group was statistically significant (P<0.10).At 10-14 days before semen collection,NO2and O3exposure concentration had a significant effect on sperm concentration,and the difference between normal group and decreased group was statistically significant (P<0.10).The concentration of O3exposure had a significant effect on the total number of sperm,and the difference between the normal group and the decreased group was statistically significant (P<0.10).There were no statistically significant differences between the normal group and the decreasing group in the semen parameters of other atmospheric pollutants (P>0.10).Conclusion The exposure of atmospheric pollutants CO,NO2and O3during sperm development have adverse effect on sperm concentration and total sperm count,and O3exposure concentration is a risk factor for decreased sperm concentration.
2020 Vol. 27 (2): 178-182 [Abstract] ( 73 ) HTML (50 KB)  PDF  (0 KB)  ( 9 )
183 Effect of hospital information on patients′ medical experience
HUANG Yong
Objective To explore the effect of hospital information on patients′ medical experience.Methods A total of 98 outpatients in our hospital from December 2017 to December 2018 were selected as the research objects,they were divided into experimental group (59 cases) and control group (59 cases) according to the method of drawing lots.The experimental group intervened by hospital information method,while the control group intervened by routine method.The intervention satisfaction,experience scores,anxiety and depression scores of the two groups were compared.Results The total satisfaction of the experimental group was higher than that of the control group,the difference was statistically significant (P<0.05).The experience scores of registration service,diagnosis and treatment service,nursing service and other services in the experimental group were higher than those in the control group,the differences were statistically significant (P<0.05).The scores of anxiety and depression in the experimental group were lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion Hospital information management can improve patients′ satisfaction and experience,and relieve patients' anxiety and depression,which is worthy of clinical application.
2020 Vol. 27 (2): 183-185 [Abstract] ( 80 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
186 Application value of PDCA management model in hospital medical insurance management
WANG Chang-jun
Objective To analyze the application value of PDCA management model in hospital medical insurance management.Methods A total of 69 patients admitted to our hospital from October 2016 to October 2017 were selected as the control group for routine management.A total of 69 patients admitted to our hospital from November 2017 to October 2018 were selected as the observation group and adopted PDCA management model.Overall satisfaction,total hospital expenses,drug proportion and length of stay were compared under the two management methods.Results The overall satisfaction of the observation group was higher than that of the control group,and the difference was statistically significant (P<0.05).Before management,there were no significant differences in total hospitalization cost,length of hospitalization,and proportion of drugs between the two groups of patients (P>0.05).After management,the total cost of hospitalization of the two groups was lower than that before management,the proportion of drugs was lower than that before management,and the length of hospitalization was shorter than that before management,and the differences were statistically significant (P<0.05).After management,the total cost of hospitalization in the observation group was lower than that of the control group,the proportion of drugs was lower than that of the control group,and the length of hospitalization was shorter than that of the control group,the differences were statistically significant (P<0.05).Conclusion The application of PDCA management in the hospital medical insurance management can effectively improve the overall satisfaction of patients with nursing,control the hospitalization cost,hospitalization time indicators,and has clinical application value.
2020 Vol. 27 (2): 186-188转192 [Abstract] ( 78 ) HTML (33 KB)  PDF  (0 KB)  ( 18 )
189 Application effect of PDCA circulation management method in hospital surgical instruments cleaning
ZHU Wen-qiang； WU Xue-ting
Objective To explore the application effect of PDCA circulation management method in hospital surgical instruments cleaning.Methods From January to December 2018,100 surgical instruments of various types were selected from the disinfection supply center of our hospital,and an observation group was formed with 30 staff members to implement PDCA circulation management method.From January to December 2017,100 pieces of various surgical instruments were selected from the disinfection supply center of our hospital,and a control group was formed with 30 staff members to implement the routine management method.The qualified rate of surgical instrument cleaning,the score of theoretical knowledge and operation skills of department staff,the management of operating room equipment,and the satisfaction of department staff were observed and compared.Results After management,the qualified rate of surgical instrument cleaning in the observation group was higher than that in the control group,with statistically significant difference (P<0.05).The scores of theoretical knowledge and operational skills of the staff in the observation group were higher than those in the control group,with statistically significant differences (P<0.05).The total satisfaction of the staff in the observation group was higher than that in the control group,and the difference was statistically significant (P<0.05).In the observation group,the loss of the number of operating room instruments,the loss of postoperative instruments and the wet bag rate after sterilization were all lower than those in the control group,with statistically significant differences (P<0.05).Conclusion The application of PDCA circular management method in the cleaning of surgical instruments in hospitals can improve the rate of clearance of surgical instruments in hospitals,improve the professional level of staff,improve the satisfaction of departments,and can be vigorously promoted and used in clinical practice.
2020 Vol. 27 (2): 189-192 [Abstract] ( 88 ) HTML (36 KB)  PDF  (0 KB)  ( 18 )
193 Application effect of SHEL model in the safety management of emergency intravenous medication
ZHU Ke； XIA Dong-mei
Objective To explore the application effect of SHEL model in the safety management of emergency intravenous medication.Methods Since February 1,2018,SHEL model hads been applied in the safety management of intravenous medication in the emergency department of our hospital.A total of 83 patients were randomly selected for intravenous administration before and after administration.The nursing safety issues,professional level scores and total nursing satisfaction of 28 nursing staff in our emergency department before implementation (from January 2017 to January 2018) and after implementation (from February 2018 to February 2019) were observed and compared.Results The incidence rates of intravenous medication nursing errors,nurse-patient disputes and complaints in the emergency department after the implementation were lower than those before the implementation,the scores of theoretical knowledge and practical operation were higher than those before the implementation,and the total nursing satisfaction was higher than that before the implementation,the differences were statistically significant (P<0.05).Conclusion The application of SHEL model in the course of intravenous medication in emergency department can effectively improve the safety of drug use,enhance the professionalism and accuracy of nursing behaviors of nurses,improve the quality of intravenous medication and nursing satisfaction of patients.
2020 Vol. 27 (2): 193-195 [Abstract] ( 68 ) HTML (33 KB)  PDF  (0 KB)  ( 14 )
196 Application effect of process quality monitoring in nosocomial infection of hospitalized critical patients
WANG Zhong-yi
Objective To explore the application effect of process quality control in nosocomial infection of hospitalized critical patients.Methods A total of 200 hospitalized critical patients admitted to our hospital from February 2015 to February 2016 were selected as the research objects,and they were divided into observation group and control group according to the method of drawing lots,with 100 cases in each group.The observation group adopted the method of process quality control,while the control group adopted the conventional method of monitoring.The incidence of positive ventilator-associated pneumonia (VAP),catheter-related urinary tract infection,central venous catheter-related blood flow infection and management quality scores were compared between the two groups.Results The VAP infection rate of the observation group was 2.00%,which was lower than that of the control group (10.00%),and the difference was statistically significant (P<0.05).The incidence of catheter-related urinary tract infection in the observation group was 5.00%,which was lower than that in the control group (20.00%),and the difference was statistically significant (P<0.05).The central venous catheter-related bloodstream infection rate was 7.00% in the observation group,which was lower than that in the control group (25.00%),the difference was statistically significant (P<0.05).The management quality score of hospitalized critically ill patients after management of the observation group was (90.12±0.25) points,which was higher than that of the control group for (81.25±2.11) points,and the difference was statistically significant (P<0.05).Conclusion After the implementation of process quality monitoring in hospitalized critical patients,significant results have been achieved,which can not only reduce the incidence of VAP infection,catheter-related urinary tract infection,central venous catheter-related blood flow infection,but also improve the quality of patient management score.
2020 Vol. 27 (2): 196-198 [Abstract] ( 70 ) HTML (30 KB)  PDF  (0 KB)  ( 19 )
199 Clinical effect of He-Ne laser irradiation on incision fat liquefaction after inguinal hernia surgery
DENG Zuo-mei； LIU Hua-zhi； WU Lian-xiang； LIU Yue-quan； DUAN Zhen-qi； ZHANG Feng-ying； YI Qiu-xiang
Objective To investigate the clinical effect of He-Ne laser irradiation on incision fat liquefaction after inguinal hernia surgery.Methods A total of 40 patients with incision fat liquefaction after inguinal hernia repair in our hospital from January 2015 to December 2018 were selected as the research objects,and they were divided into control group and observation group by random number table method,20 cases in each group.The control group was treated with conventional dressing change.The observation group was treated with He-Ne laser irradiation on the basis of routine dressing change.The therapeutic effect of the two groups were compared,and the wound healing time and treatment satisfaction of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant (P<0.05),the healing time of incision in the observation group was (6.20±2.35) d,which was shorter than that in the control group (9.25±3.24) d,and the difference was statistically significant (P<0.05);the total satisfaction rate of the observation group was 95.00% (19/20),which was higher than that of the control group 80.00% (16/20),the difference was statistically significant (P<0.05).Conclusion He-Ne laser irradiation in the treatment of incision fat liquefaction after inguinal hernia surgery can achieve good results,promote the healing of incision and improve patient satisfaction.
2020 Vol. 27 (2): 199-201 [Abstract] ( 77 ) HTML (36 KB)  PDF  (0 KB)  ( 17 )
202 Application effect of predictive risk management and nursing in pediatric nursing management
HUANG Li-qun； YAO Shao-ling； YUAN Mei-mei； YANG Yi-fang
Objective To observe the effect of predictive risk management and nursing in pediatric nursing management.Methods A total of 250 patients with pediatrics from April 2016 to May 2018 were selected as study objects.According to the method of drawing lots,they were divided into observation group (125 cases) and control group (125 cases).The control group was received routine nursing,and the observation group was used predictive risk management nursing,the nursing total satisfaction,risk incidence and quality of nursing scores of the two groups were compared.Results The total satisfaction of the observation group was 96.00%,which was higher than that of the control group(88.00%),the difference was statistically significant (P<0.05).The total incidence of nursing risk in the observation group was 4.00%,which was lower than that in the control group (12.00%),and the difference was statistically significant (P<0.05).The quality of nursing scores for critically ill patients,ward management score and basic nursing quality score of the observation group were higher than those of the control group,and the differences were statistically significant (P<0.05).Conclusion The application of predictive risk management in pediatric nursing can reduce the risk of pediatric nursing,and the clinical application and promotion value is high.
2020 Vol. 27 (2): 202-204 [Abstract] ( 76 ) HTML (33 KB)  PDF  (0 KB)  ( 16 )
205 Application effect of alginate combined with hydrocolloid dressing in peri-ostomy dermatitis
LI Yan-xiang； XIE Yu-lan； WANG Xiao-hui； HU Ling-yan
Objective To observe the clinical effect of alginate combined with hydrocolloid dressing in the treatment of peri-ostomy dermatitis.Methods Forty-eight patients with peripheral dermatitis after bowel fistula admitted to our hospital from January to December 2018 were enrolled in the study as subjects.They were divided into observation group(24 cases) and control group (24 cases) according to the order of admission.The observation group used alginate combined with hydrocolloid dressing,and the control group used skin protective film plus skin care powder,the rate of inflammation regression and treatment effect between two group were compared.Results The total effective rate of the observation group was 91.66%,which was higher than that of the control group (66.66%),the difference was statistically significant (P<0.05).There was no significant difference in peristomal skin score tool (DET/AIM) scores between the two groups at 3 and 6 d (P＞0.05).The scores of DET/AIM in the observation group on the 6,9 and 12th d were lower than that treatment for 3 d,the differences were statistically significant (P<0.05).the DET/AIM scores of the control group for 9 and 12 days were lower than the treatment for 3 d,the differences were statistically significant (P<0.05).Conclusion The application of hydrocolloid dressing combined with alginate in peripheral dermatitis after enterostomy has significant therapeutic effect and is of high clinical application and promotion value.
2020 Vol. 27 (2): 205-207 [Abstract] ( 64 ) HTML (31 KB)  PDF  (0 KB)  ( 14 )
208 Application effect of high quality nursing in pediatric clinical nursing
SONG Ping
Objective To explore the application effect of high quality nursing in pediatric clinical nursing.Methods A total of 200 cases of pediatric patients admitted to our hospital from June 2016 to February 2019 were selected.According to the principle of randomized control,they were divided into control group and treatment group,100 cases in each group.The control group adopted the traditional nursing mode,while the treatment group carried out high quality nursing on this basis.The scores of nursing service quality,the compliance of nursing and treatment during hospitalization,the occurrence of nursing errors and the satisfaction of family members at discharge were compared between the two groups.Results The scores of health education,service attitude,communication ability,professional skills,disease understanding,problem solving ability and management of responsible ward in the treatment group were higher than those in the control group,the differences were statistically significant (P<0.05).The total compliance of nursing and treatment during hospitalization in the treatment group was higher than that in the control group,the incidence of nursing errors was lower than that of the control group,the differences were statistically significant (P<0.05).The total satisfaction of the family members in the treatment group was higher than that in the control group,the difference was statistically significant (P<0.05).Conclusion High quality nursing can improve the quality and compliance of paediatric nursing service and reduce the risk of nursing errors,which is worthy of clinical application.
2020 Vol. 27 (2): 208-210 [Abstract] ( 68 ) HTML (32 KB)  PDF  (0 KB)  ( 11 )
211 Influence analysis of personalized health education on medical disputes among family members of hospitalized children with hand，foot and mouth disease
CHEN Ming； YU Xiang-lin； WEI Li
Objective To explore the influence of personalized health education on medical disputes among family members of hospitalized children with hand,foot and mouth disease (HFMD).Methods A total of 106 hospitalized children with HFMD treated in our hospital from September 2017 to June 2018 were selected.According to the principle of randomized control,they were divided into group A and group B,53 cases in each group.One family member was designated as caregiver for each child.A total of 106 family members were included in the study.Group B the family members were given routine health education.Group A was given personalized health education for family members.The cognitive level of the family members of the children to the disease,the compliance of the family members to the health behavior of the disease,hospitalization time and nursing satisfaction were observed.Results The cognitive rate of family members of group A was higher than that of group B,the difference was statistically significant (P<0.05).The compliance of family members of group A was higher than that of group B,the difference was statistically significant (P<0.05).The hospitalization time of group A was shorter than that of group B,the difference was statistically significant (P<0.05).The total nursing satisfaction of group A was higher than that of group B,the difference was statistically significant (P<0.05).There was no medical dispute between group A and group B,there was no significance difference in the incidence of medical disputes between the two groups (P＞0.05).Conclusion Personalized health education has a positive effect on the cognition and behavior of family members of hospitalized children with HFMD and has a positive effect on reducing medical disputes.
2020 Vol. 27 (2): 211-213转220 [Abstract] ( 92 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
214 Effect of behavioral and environmental nursing interventions on pain and vital signs in neonatal brachial artery collection
LI Jian-zhang； YE Jian-zhong； XIE Yu-fang
Objective To analyze the effect of behavioral and environmental nursing intervention on pain and vital signs in neonatal radial artery blood collection.Methods A total of 200 neonates treated in Guancheng Hospital of Dongguan City from March 2018 to March 2019.were selected,they were randomly divided into control group and study group,100 cases in each group.All neonates were selected for radial artery blood collection.The control group was given routine nursing,the study group was given behavioral and environmental nursing intervention based on routine nursing.The pain and vital signs of the two groups were compared.Results The neonatal pain score of the study group was(2.70±0.69)points and that of the control group was(7.78±1.77)points.The neonatal pain score of the study group was lower than that of the control group,the difference was statistically significant (P<0.05).The heart rate,mean arterial pressure,oxygen saturation and respiratory rate of the study group before and after blood collection had no statistically significance(P＞0.05).The heart rate,mean arterial pressure and oxygen saturation of the control group after blood collection were higher than those before blood collection,and the respiratory rate was lower than that before blood collection，with statistical differences(P<0.05);The heart rate,mean arterial pressure and respiratory rate of the study group after blood collection were lower than those of the control group,and the oxygen saturation of blood was higher than that of the control group,the differences were statistically significant(P<0.05).The duration of crying during blood collection in the study group was (7.55±3.10) s,while that in the control group was (15.44±6.99) s.The duration of crying in the study group was shorter than that in the control group,the difference was statistically significant (P<0.05).Conclusion For newborns,the application of behavioral and environmental nursing intervention in radial artery blood collection can not only alleviate pain,but also keep vital signs stable.It has significant clinical value and is worth popularizing and applying.
2020 Vol. 27 (2): 214-216 [Abstract] ( 86 ) HTML (34 KB)  PDF  (0 KB)  ( 12 )
217 Application effect of rehabilitation nursing in elderly patients with intertrochanteric fractures
WANG Jing; WANG Tian-tian; RONG Feng-ju; KANG Li-na; DING Ying-ying
Objective To explore the applicatiion effect of rehabilitation nursing in elderly patients with intertrochanteric fractures.Methods From July 2015 to April 2017,200 cases of elderly patients with femoral intertrochanteric fracture treated Hongqi Hospital Affiliated to Mudanjiang Medical University were selected as the research objects,according to random number table method,they were divided into the control group (100 cases) and observation group (100 cases).The control group was given routine nursing method,the observation group was given rehabilitation nursing.Surgery,hospitalization,complications,and hip function score (Harris) were compared between the two groups.Results Intraoperative blood loss in the observation group was less than that in the control group,and the difference was statistically significant (P<0.05).The operation time and hospitalization of the observation group were shorter than those of the control group,and the differences were statistically significant (P<0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant (P<0.05).Harris score in the observation group was higher than that in the control group,and the difference was statistically significant (P<0.05).Conclusion The application of rehabilitation nursing in elderly patients with intertrochanteric fractures is effective,which can reduce intraoperative blood loss,shorten the duration of surgery and hospitalization,reduce the incidence of complications and promote the recovery of joint function.
2020 Vol. 27 (2): 217-220 [Abstract] ( 83 ) HTML (36 KB)  PDF  (0 KB)  ( 13 )
221 Application effect of comprehensive nursing intervention on children′s inguinal hernia in perioperative period
WU Ping-ping
Objective To observe the effect of comprehensive nursing intervention in perioperative period of inguinal hernia in children.Methods Clinical data of 50 pediatric inguinal hernia patients admitted from March 2018 to September were selected and divided into observation group (n=25) and control group (n=25) according to different nursing methods.The children in the control group was given routine nursing mode for intervention.The children in the observation group was given comprehensive nursing mode for intervention.The postoperative time of leaving bed and hospitalization,postoperative pain,complications and nursing satisfaction of the two groups were compared.Results The time of leaving bed and hospitalization in the observation group were shorter than those in the control group,the differences were statistically significant (P<0.05).The degree of postoperative pain in the observation group was lower than that in the control group,and the difference was statistically significant (P<0.05).The total incidence of postoperative complications in the observation group (4.00%) was lower than that in the control group (28.00%),and the difference was statistically significant (P<0.05).The total postoperative nursing satisfaction of the observation group was 96.00%,which was higher than that of the control group (76.00%),and the difference was statistically significant (P<0.05).Conclusion The application of comprehensive nursing intervention in perioperative period of pediatric inguinal hernia is beneficial to reduce the incidence of pain and complications,shorten the hospitalization,improve the family′s satisfaction with nursing services,which is worthy of clinical promotion.
2020 Vol. 27 (2): 221-223 [Abstract] ( 77 ) HTML (32 KB)  PDF  (0 KB)  ( 14 )
224 Application effect of holistic nursing mode in patients with gallstone surgery
LI Ye-qing; HAN Xi
Objective To analyze the application effect of holistic nursing mode in patients with gallstone surgery.Methods A total of 94 patients with gallstone surgery admitted to our hospital from January 2017 to January 2019 were selected and randomly divided into the control group (n=47) and the observation group (n=47).The control group was given routine nursing,the observation group was given holistic nursing based on the control group.The nursing effects of the two groups were compared.Results The scores of pain and negative emotion in the observation group were lower than those in the control group,and the scores of physical comfort,psychological comfort,social comfort and environmental comfort were all higher than those in the control group,with statistical differences (P<0.05).Conclusion It is of high clinical value to adopt holistic nursing for the patients after the operation of gallstones to reduce the degree of postoperative pain and improve the psychological state of the patients
2020 Vol. 27 (2): 224-226 [Abstract] ( 79 ) HTML (34 KB)  PDF  (0 KB)  ( 15 )
227 Application effect of cross opening method for foam dressing on the prevention of stress injury in patients with cardiology
YU Ling; WANG Dan; GAO Li
Objective To observe the clinical application effect of cross opening method in preventing pressure injury with foam dressing.Methods From January 2016 to July 2018,114 patients admitted in our hospital with Braden score less than 18 points and no or less stress injury patients were selected and randomly divided into observation group and control group,57 cases in each group.Both groups were given normal stress injury prevention nursing,and foam dressings to be used to protect in cases.In the observation group,foam dressing was also used in prone areas of pressure injury.In the observation group,the foam dressing was applied after the cross window method was applied,the control group was pasted completely.Incidence of pressure damage,frequency of foam dressing change and nursing satisfaction between two group were compared.Results Comparison of the incidence of pressure injury between the observation group and the control group,the difference had no statistical significance (P＞0.05),but the frequency of dressing change was lower than that of the control group,and the total nursing satisfaction of the observation group was higher than that of the control group,the differences were statistically significant (P<0.05).Conclusion The cross opening method can effectively prevent the occurrence of pressure injury in the clinical application of foam dressing for the prevention of patients with stress injury,and reduce the frequency of dressing replacement,in order to reduce the cost of patients and the occurrence of nursing complications,improve nursing satisfaction.
2020 Vol. 27 (2): 227-229 [Abstract] ( 69 ) HTML (32 KB)  PDF  (0 KB)  ( 15 )
230 Application effect of comfortable nursing in patients with hyperbaric oxygen therapy
HUANG Zhuo-ling; CHEN Ying-rou; ZHANG Xu-tian
Objective To investigate the application effect of comfortable nursing in patients with hyperbaric oxygen(HBO) therapy.Methods A total of 300 patients with HBO treatment in our hospital from January 2017 to December 2018 were selected as subjects.By random number table method,they were divided into observation group and control group,150 cases in each group.In the control group,the basic nursing was used,while in the observation group,comfortable nursing was added besides the basic nursing.The self-rating depression scale (SDS) and the anxiety self-rating scale (SAS) scores of the two groups were compared before and after treatment.The total incidence of middle ear barotrauma and the number of treatments were also compared in the two groups.Results Comparison of SDS and SAS scores between two groups before nursing,the differences were no statistically significant (P＞0.05).After nursing,the SDS and SAS scores of the two groups were lower than those before the nursing,the SDS and SAS scores of the observation group after nursing were lower than those of the control group,with statistical differences (P<0.05).The incidence of middle ear barotrauma in the observation group was lower than that in the control group,the difference was statistically significant (P<0.05).The number of treatments in the observation group was less than that in the control group,the difference was statistically significant (P<0.05).Conclusion Comfortable nursing can effectively alleviate patient′s anxiety,reduce the incidence of adverse reactions and the incidence of middle ear barotraumas,and improve the treatment effect.
2020 Vol. 27 (2): 230-232 [Abstract] ( 72 ) HTML (31 KB)  PDF  (0 KB)  ( 13 )
233 Application effect of targeted nursing on prevention of infection in patients with continuous blood purification
LIANG Jian-yi; WU Yan-hua
Objective To explore the effect of targeted nursing on the prevention of infection in patients with continuous blood purification (CBP).Methods A total of 49 patients with CBP treated in our hospital from September 2017 to July 2018 were selected as subjects.The patients were divided into treatment group (28 cases) and control group (21 cases)according to random number table method.The control group was given emergency room general nursing,the treatment group was given targeted nursing intervention.The changes of serological indexes before and after the intervention of the two groups,the incidence of infection,and health knowledge mastery of the two groups after the intervention were compared.Results After the intervention,interleukin-6(IL-6),interleukin-10(IL-10)and tumor necrosis factor-α (TNFα) in the treatment group were lower than that before the intervention,and IL-6,IL-10 and TNF-α in the treatment group were lower than those in the control group,the differences were statistically significant (P<0.05).The total incidence of infection in the treatment group was lower than that in the control group,the difference was statistically significant (P<0.05),and the health knowledge mastery rate of the treatment group was higher than that in the control group,the difference was statistically significant (P<0.05).Conclusion Targeted nursing can improve the serological indexes of patients with CBP,reduce the probability of infection,improve the overall health knowledge mastery of patients.
2020 Vol. 27 (2): 233-235 [Abstract] ( 76 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
236 Application effect of equipment nurse′s targeted nursing in cesarean section
GUO Fang; SONG Qing-jie; YI Li-li
Objective To explore the application effect of targeted nursing by equipment nurses in cesarean section.Methods A total of 80 cases with undergoing cesarean section in the lower uterine segment admitted in our hospital from January 2016 to September 2018 were selected and divided into control group and observation group according to random number table method,40 cases in each group.The control group was given routine intervention during the operation,and the observation group was given targeted nursing.Follow-up for 6 months,then the operation-related indexes were compared,and the abdominal and pelvic pain numerical score (NRS) for 6 months after the operation was counted.The clinical symptoms and diagnosis of endometriosis were definitely found in the follow-up in the two groups.Results The operation time and hospitalization time in the observation group were shorter than those of the control group,and the intraoperative blood loss was less than that the control group,the differences were statistically significant (P<0.05).The NRS scores in the observation group were lower than those of the control group at discharge and 1,6 months after operation,the differences were statistically significant (P<0.05).The incidence of postoperative abdominal pain and lower abdominal drop in the observation group were lower than those of the control group,and the incidence of endometriosis was lower than that of the control group,the differences were statistically significant (P<0.05).Conclusion Effective nursing training for equipment nurses undergoing cesarean section can shorten the operation time and hospitalization time of patients,and it can reduce postoperative pain and reduce the incidence of postoperative endometriosis.
2020 Vol. 27 (2): 236-238 [Abstract] ( 71 ) HTML (34 KB)  PDF  (0 KB)  ( 11 )
239 Application effect of compound thermal insulation nursing after children complex congenital heart surgery
XIONG Ying； YANG Shuang
Objective To investigate application effect of compound thermal insulation nursing after children complex congenital heart surgery.Methods A total of 68 children with congenital heart disease were selected in our hospital from December 2012 to December 2016，they were divided into control group and observation group by random number table method,34 cases in each group.The control group received routine nursing,the observation group received composite thermal insulation nursing.Changes of vital signs (body temperature,heart rate,mean arterial pressure) during perioperative period (beginning of operation,30，60,90 minutes,and the end of operation),comfort degree,complications were compared between two groups.Results Temperature and mean arterial pressure at times of operation 30,60,90 min,and the end of operation in observation group were higher than those of the control group,while differences were statistically significant (P<0.05).Heart rate at times of operation 30,60,90 min,and the end of operation in observation group were lower than those of the control group,while differences were statistically significant (P<0.05).Perioperative comfort degree in observation group was better than that of the control group,while difference was statistically significant (P<0.05).The incidence of complications in observation group was 2.9%,which was lower than that of the control group 20.6%,while difference was statistically significant (P<0.05).Conclusion Composite thermal insulation nursing can improve perioperative safety in children with complex congenital heart disease,which can stable hemodynamics and worth of clinical use.
2020 Vol. 27 (2): 239-241转249 [Abstract] ( 76 ) HTML (36 KB)  PDF  (0 KB)  ( 11 )
242 Effectof comprehensive nursing on deep venous thrombosis of lower extremity in elderly patients with lower extremity fractures
ZHU Dong-mei； ZHANG Jia-xiong； LIU Yi-shang
Objective To investigate the effect of comprehensive nursing on the deep venous thrombosis (DVT) of lower extremity in elderly patients with lower extremity fractures.Methods A total of 167 elderly patients with lower extremity fractures in our hospital were selected from June 2017 to June 2018.According to random envelope method,they were divided into the comprehensive nursing group (85 cases) and routine nursing group (82 cases).All patients in the routine nursing group were given routine nursing,the patients in comprehensive nursing group were given comprehensive nursing including health education,psychological care,diet management and early rehabilitation nursing besides routine nursing.Incidence of DVT,psychological status and nursing satisfaction between two groups were compared.Results The incidence of DVT in the comprehensive nursing group was 2.35%,which was lower than 12.20% in the routine nursing group,the difference was statistically significant (P<0.05).The self-rating anxiety scale (SAS) score after comprehensive nursing was lower than that in the routine nursing group,the difference was statistically significant(P<0.05).The satisfaction score with nursing in the comprehensive nursing group was higher than that in the routine nursing group,the difference was statistically significant (P<0.05).Conclusion Comprehensive nursing can effectively reduce the incidence of DVT in elderly patients with lower extremity fractures,relieve patients′ anxiety and improve patient satisfaction with nursing.
2020 Vol. 27 (2): 242-245 [Abstract] ( 70 ) HTML (37 KB)  PDF  (0 KB)  ( 17 )
246 Effect of targeted nursing intervention on mental state and recovery in uterine fibroid patients
WANG Jian-ying
Objective To observe the effect of targeted nursing intervention on mental state and recovery in uterine fibroid patients.Methods A total of 76 cases of uterine fibroid patient treated in our hospital from January 2016 to May 2018 were selected and divided into control group and observation group by random number table method,38 cases in each group.The control group took routine nursing,while the observation group was given targeted nursing intervention.The mental state,postoperative gastrointestinal recovery,postoperative complications,nursing satisfaction,quality of life scale (QOL) in the two groups were compared.Results The scores of self-rating depression scale (SDS) and self-rating anxiety scale (SAS) in observation group were lower than that of the control group,the differences were statistically significant (P<0.05).The exhaust time,recovery time of bowel sound,defection time,eating time in observation group were shorter than those of the control group,the differences were statistically significant (P<0.05).The total incidence of vaginal bleeding,urinary system infection,incision infection,abdominal pain and distention in observation group was lower than that in the control group,the difference was statistically significant (P<0.05).The nursing total satisfaction and QOL scores in observation group were higher than those of the control group,the differences were statistically significant (P<0.05).Conclusion Targeted nursing intervention for uterine fibroid patients can relieve anxiety,reduce postoperative complications,promote recovery,increase nursing satisfaction and living quality,which is worthy of clinical application and promotion.
2020 Vol. 27 (2): 246-249 [Abstract] ( 89 ) HTML (33 KB)  PDF  (0 KB)  ( 11 )
250 Application effect of continuous nursing mode based on Wechat platform in PICC management of cancer patients
LI Jia; LI Li-hui; ZOU Dan-feng
Objective To study the application effect of Wechat platform in the continuous nursing of patients with tumors discharged from central vein catheterization via peripheral vein (PICC) tube.Methods From November 2017 to November 2018,100 patients with tumors who were treated with PICCcatheter and discharged from our hospital were enrolled in the study.They were randomly divided into control group and experimental group use the envelope,50 cases in each group.The patients in the control group were treated with routine continuation after discharge.The patients in the experimental group were given continuous nursing intervention based on Wechat platform after discharge,and the complication rate and nursing satisfaction of the two groups were compared.Results The complication rate of the experimental group was 10.00% (5/50),which was lower than that of the control group (26.00%),the difference was statistically significant (P<0.05).The total satisfaction of the experimental group was 96.00%,which was higher than that of the control group (70.00%),the difference was statistically significant (P<0.05).Conclusion The application of Wechat platform in the continuous nursing of patients with tumors discharged from the PICCtube can reduce the occurrence of complications and greatly improve the satisfaction of patients with tumors discharged from the hospital.It is worthy of clinical promotion.
2020 Vol. 27 (2): 250-252 [Abstract] ( 78 ) HTML (32 KB)  PDF  (0 KB)  ( 13 )
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