中老年人群碘营养状况监测与桥本甲状腺炎影响因素的调查研究

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Abstract Objective To clarify the iodine nutritional status of middle-aged and elderly people,to guide the residents to supplement iodine scientifically,and to explore the risk factors of Hashimoto′s thyroiditis,so as to provide scientific basis for the prevention and treatment of thyroid diseases.Methods Stratified sampling was used to select 600 middleaged and elderly people who were hospitalized and underwent health check-ups in Changqing People′s Hospital of Ji′nan City from May 2019 to January 2020.The survey subjects were from the permanent residents of various towns and streets in Changqing District,the clinical data of gender,age,medical history,blood pressure,blood lipids,thyroid function and thyroid ultrasound examination were collected,and urine iodine test was performed.A total of 56 patients who met the diagnostic criteria for Hashimoto′s thyroiditis were regarded as the Hashimoto group,and 401 subjects with no significant difference in age structure from the Hashimoto group were selected as the control group.Single factor analysis and multivariate Logistic regression were used to analyze the possible influencing factors for incidence of Hashimoto′s thyroiditis.Results The median urinary iodine was 152.7 μg/L,61 cases(10.17%)were iodine deficient,and 39 cases(6.50%)were iodine excess.There were statistically significant differences in the incidence of hypertension and the proportion of no comorbidities between the two groups(P＜0.05).There were no significant differences in gender,age,smoking history,drinking history,dyslipidemia,cerebral infarction,coronary heart disease,diabetes between the two groups(P＞0.05).There were statistically significant differences in the serum thyroid stimulating hormone(TSH),thyroglobulin antibody(TGAb)and thyroid peroxidase antibody(TPOAb)levels between the two groups(P＜0.05).There were no significant differences in the levels of free triiodothyronine(FT3),free thyroxine(FT4)and urine iodine between the two groups(P＞0.05).The results of multivariate Logistic regression analysis showed that TSH(OR=1.251,95%CI: 1.163-1.346, P＜0.05),TGAb(OR=1.016,95%CI: 1.012-1.020, P＜0.05),TPOAb(OR=1.010,95%CI:1.006-1.014, P＜0.05)were risk factors for incidence of Hashimoto′s thyroid,no comorbidities were protection factors for incidence of Hashimoto′s thyroid(OR=0.188,95%CI: 0.054-0.653, P＜0.05).Conclusion Population surveyed are generally at the appropriate level of iodine nutrition,with large individual differences.Some iodine deficient people are caused by blindly avoiding iodine diet.No comorbidities are the protective factor of Hashimoto′s thyroiditis,and TSH,TGAb and TPOAb are the risk factors of Hashimoto′s thyroiditis.The risk of Hashimoto′s thyroiditis increases by 1.251 times when TSH increases by 1 unit.

Key words： Iodine nutrition Urinary iodine Hashimoto&prime s thyroiditis Thyroid function

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	Articles by authors
	WU Xia-wen
	DUAN Zong-mei
	ZHUANG Xiu-yun
	HAN Ting-ping
	YE Guang-li

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WU Xia-wen,DUAN Zong-mei,ZHUANG Xiu-yun, et al. Monitoring of iodine nutritional status in middle-aged and elderly population and investigation research on the influencing factors of Hashimoto′s thyroiditis[J]. 中国当代医药, 2021, 28(17): 206-210.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I17/206

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