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| Effect of Atropine combined with hemoperfusion in the treatment of severe organophosphorus pesticide poisoning |
| CHEN Zhi-qiang SU Gan-bin |
| Department of Emergency Internal Medicine,Quanzhou Guangqian Hospital |
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Abstract Objective To investigate the clinical effect of Atropine combined with hemoperfusion in the treatment of severe organophosphorus pesticide poisoning. Methods A total of 90 patients with severe organophosphorus poisoning admitted to the Emergency Internal Medicine Department of Quanzhou Guangqian Hospital from February 2018 to June 2020 were selected and randomly divided into the anticholinergic group (44 cases) and the hemoperfusion combined with anticholinergic group (46 cases) by drawing lots. The anticholinergic group was treated with Atropine on the basis of routine treatment, and the hemoperfusion combined with anticholinergic group was given hemoperfusion therapy on the basis of the anticholinergic group. The curative effect of the two groups were compared, and the changes of blood gas analysis indexes and rehabilitation of the patients were tracked. Results After 3 days of treatment, pH value (7.48±0.20)and arterial partial pressure of oxygen(PaO2)([71.97±5.68]mmHg)in the hemoperfusion combined with anticholinergic group were higher than those in the anticholinergic group [7.20±0.14], [61.25±6.87] mmHg), the differences were statistically significant (t=7.662, 8.083; P＜0.05). The arterial partial pressure of carbon dioxide (PaCO2) in the hemoperfusion combined with anticholinergic group ([36.49±5.13] mmHg) was lower than that of the anticholinergic group ([44.72±4.19] mmHg), and the difference was statistically significant (t=8.314, P＜0.05). The total effective rate in the hemoperfusion combined with anticholinergic group (91.30%) was higher than that in the anticholinergic group (72.73%), and the total incidence of complications in the hemoperfusion combined with anticholinergic group (13.04%) was lower than that in the anticholinergic group (31.82%), and the differences were statistically significant (χ2=5.310, 4.586; P＜0.05).Conclusion Atropine combined with hemoperfusion in the treatment of severe organophosphorus pesticide poisoning can quickly improve the liver function of patients, reduce the risk of complications, improve the severity of the disease,and promote the patients to recover and leave the hospital as soon as possible. It is of high value in the treatment of severe organophosphorus pesticide poisoning.
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