鞘内注射与静脉滴注抗生素治疗重型颅脑损伤继发颅内感染的临床效果

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Abstract Objective To investigate the clinical efficacy of intrathecal injection and intravenous drip of antibiotics in the treatment of secondary intracranial infection after severe craniocerebral injury.Methods A total of 120 patients with severe craniocerebral injury secondary intracranial infection admitted to Zhongshan Torch Development Zone Hospital were selected as the research objects.They were divided into observation group and control group by random number table method,with 60 cases in each group.The control group was given systemic intravenous drip of vancomycin and meropenem on the basis of conventional treatment,while the observation group was given intrathecal injection of vancomycin and meropenem on the basis of conventional treatment.The clinical therapeutic effect,prognosis and safety of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,the time of fever reduction,white blood cell return to normal and cure time were shorter than that of the control group,and the total cost of treatment was lower than that of the control group,the differences were statistically significant(P＜0.05).Before treatment,there were no significant differences in the indexes of high mobility group protein-1(HMGB-1)and receptor for advanced glycation end products(RAGE)in cerebrospinal fluid of the two groups(P＞0.05),the HMGB-1 and RAGE indexes of the observation group were lower than those of the control group after 7 days of treatment,the differences were statistically significant(P＜0.05).The incidence of adverse reactions and sequelae in observation group was lower than that in control group,and the difference was statistically significant(P＜0.05).Conclusion Intrasheath injection of antibiotics in the treatment of intracranial infection secondary to severe craniocerebral injury can effectively and quickly control the patient′s infection condition,with more significant clinical efficacy and lower risk of adverse reactions and sequelae after treatment,which has clinical application and promotion value.

Key words： Intrathecal injection Systemic intravenous drip Antibiotic therapy Severe craniocerebral injury Clinical efficacy Adverse reaction Sequela

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	LYU Zhi-gui
	LIN Xian-jie

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LYU Zhi-gui,LIN Xian-jie. Clinical effects of intrathecal injection and intravenous drip of antibiotics in the treatment of secondary intracranial infection after severe craniocerebral injury[J]. 中国当代医药, 2021, 28(13): 102-105.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I13/102

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