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| Application effects of nucleus accumbens combined with anterior limb of internal capsule as the target of deep brain stimulation in the treatment of refractory obsessive-compulsive disorder |
| HE Jun-yan |
| Department of Psychiatry,Kangning Hospital of Jinzhou City,Liaoning Province,Jinzhou 121000,China |
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Abstract Objective To explore the application effects of nucleus accumbens combined with anterior limb of internal capsule as the target of deep brain stimulation in the treatment of refractory obsessive-compulsive disorder.Methods A total of 60 patients with refractory obsessive-compulsive disorder admitted to Kangning Hospital of Jinzhou City from July 2017 to July 2018 were selected as the control group,and a total of 58 patients with refractory obsessive-compulsive disorder admitted to Kangning Hospital of Jinzhou City from August 2018 to August 2019 were selected as the observation group.The control group treated with anterior limb of internal capsule as the target of deep brain stimulation,and the observation group treated with nucleus accumbens combined with anterior limb of internal capsule as the target of deep brain stimulation.The improvement of symptoms and the mental states of patients were compared between the two groups,and the recurrence was counted within 6 months after treatment.Results Six months after treatment,the Yale-Brown Obsessive Compulsive Scale(Y-BOCS)score of the observation group were lower than that of the control group,the difference was statistically significant(P＜0.05).Six months after treatment,the Hamilton Anxiety Scale(HAMA)score,Hamilton Depression Scale(HAMD)score,and Symptom Check list 90(SCL-90)scores of the observation group were lower than those of the control group,the differences were statistically significant(P＜0.05).Six months after treatment,the total recurrence rate of the observation group was lower than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion Nucleus accumbens combined with anterior limb of internal capsule as the target of deep brain stimulation for refractory obsessive-compulsive disorder can not only improve the compulsive behaviors,but also effectively reduce the recurrence rate of symptoms.
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| [1] |
王振.强迫症难治性的误区[J].中华精神科杂志，2020，53（2）：75-77.
|
| [2] |
吴芸昊，张陈诚，张莹莹，等.脑深部电刺激在难治性强迫症治疗中的研究进展[J].中华精神科杂志，2020，53（2）：146-150.
|
| [3] |
封洲燕，郭哲杉，王兆祥.深部脑刺激作用机制的研究进展[J].生物化学与生物物理进展，2018，45（12）：1197-1203.
|
| [4] |
刘希垄.伏核的解剖与功能及其磁共振成像研究进展[J].中国临床解剖学杂志，2016，34（2）：235-238.
|
| [5] |
邱畅，董文文，章文斌.脑深部电刺激术治疗帕金森病的脑表面微创伤处理[J].中华神经外科杂志，2019，35（10）：1015-1016.
|
| [6] |
王馨，龚飞龙，高远，等.伏隔核联合内囊前肢脑深部电刺激治疗难治性强迫症（2 例病例报告）[J].立体定向和功能性神经外科杂志，2018，31（4）：18-22.
|
| [7] |
全梓方，武衡，何栋刚，等.人脑伏隔核壳部与核部解剖的差异与临床疾病联系[J].中国临床解剖学杂志，2018，36（3）：354-356.
|
| [8] |
赵英歌，李斐，李德生，等.帕罗西汀与喹硫平联合认知行为疗法治疗强迫症的疗效分析[J].检验医学与临床，2018，15（3）：376-378.
|
| [9] |
马月娇，王东方，刘铁桥.脑深部电刺激在精神障碍治疗中的应用[J].中国临床心理学杂志，2016，14（6）：1059-1063.
|
| [10] |
周连银，汪鲁刚，唐运林，等.多靶点射频损毁术治疗难治性抽动秽语综合征的疗效分析[J].中国医学物理学杂志，2017，34（10）：1078-1080.
|
| [11] |
成洋，段丽娟，贺娟.立体定向双侧内囊前肢毁损术治疗强迫症的护理[J].护士进修杂志，2016，31（21）：1980-1982.
|
| [12] |
王滔，张陈诚，金海燕，等.腹侧内囊前肢小毁损灶治疗难治性强迫症的随访观察[J].中国微侵袭神经外科杂志，2016，21（8）：337-340.
|
| [13] |
龚飞龙，李鹏，王伟.多靶点治疗强迫缓慢型难治性强迫症1 例[J].中国微侵袭神经外科杂志，2016，1（2）：87-88.
|
| [14] |
刘希垄，李龙.伏核的解剖与功能及其磁共振成像研究进展[J].中国临床解剖学杂志，2016，34（2）：235-238.
|
| [15] |
陈小燕，董碧蓉.难治性强迫症治疗的研究进展[J].现代临床医学，2018，44（2）：152-154，157.
|
|
|
|
