初诊缺血性脑卒中患者单核细胞/高密度脂蛋白胆固醇比值与预后关系的临床研究

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Abstract Objective To explore the relationship between the monocyte/high-density lipoprotein cholesterol ratio(MHR)and the prognosis of patients initially diagnosed with cerebral arterial thrombosis.Methods A total of 120 patients with cerebral arterial thrombosis admitted to General Hospital of Pingxiang Mining Group Co.,Ltd.from July 2018 to December 2019 were selected and divided into a good group(60 cases)and a poor group(60 cases)according to the prognosis of the patients during the half-year follow-up.The basic information of the two groups of patients was collected.Routine blood tests and blood lipid tests were carried out,and their MHR was calculated.The basic information and clinical indicators of the two groups were compared,and the relationship between MHR and the prognosis of patients with cerebral arterial thrombosis was analyzed,and the value of MHR in predicting the poor prognosis of patients with cerebral arterial thrombosis.Divide 120 patients into two groups according to the ROC curve for predicting the poor prognosis of patients with cerebral arterial thrombosis was the best value,and compare their prognosis.Results The national institute of health stroke scale(NIHSS)score and MHR values of the good group were lower than those of the poor group,the number of monocytes of the good group was less than that of the poor group,and the high density lipoprotein cholesterol(HDL-C)of the good group was higherr than that of the poor group,the differences were statistically significant(P＜0.05).Age(β=-0.420,OR=1.04,95%CI=1.02-1.08),NIHSS score(β=-0.451,OR=1.32,95%CI=1.18-1.45),MHR(β=-0.562,OR= 2.38,95%CI=1.11-5.24)were the main prognostic factors of the patients with cerebral arterial thrombosis.The area under the ROC curve of MHR predicting poor prognosis of ischemic stroke was 0.694(95%CI=0.636-0.748,P＜0.05),the sensitivity and specificity were 79.41% and 58.33%,and the best cutoff value was 0.48.The recurrence rate and mortality of patients in the MHR＞0.48 group were higher than those in the MHR≤0.48 group,and the differences were statistically significant(P＜0.05).Conclusion The higher the MHR value,the more severe the nerve damage in patients initially diagnosed with ischemic stroke and the worse the prognosis.

Key words： Prognosis High density lipoprotein cholesterol Monocyte Ischemic stroke

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	Articles by authors
	SU Yu-rong
	LI Zhi-yong
	LI Huan-sheng
	YAN Guo-ping
	ZHOU Cong-bin
	WU Wen-xun

Cite this article:

SU Yu-rong,LI Zhi-yong,LI Huan-sheng, et al. Clinical study on the relationship between the monocyte/high-density lipoprotein cholesterol ratio and the prognosis of patients initially diagnosed with cerebral arterial thrombosis[J]. 中国当代医药, 2021, 28(13): 85-88.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I13/85

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