血清雌二醇、β-绒毛膜促性腺激素及孕酮水平检测在早期先兆流产结局预测中的应用价值

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Abstract Objective To explore the application value of serum estradiol (E2),β-chorionic gonadotropin (β-HCG) and progesterone (P) levels detection in predicting the outcomes of early threatened abortion.Methods Clinical data of 52 pregnant women with early threatened abortion who were admitted to Maternity and Child Health Family Planning Service Center in Yingde City,Guangdong Province from August 2019 to July 2020 was selected and divided into continued pregnancy group (36 cases) and pregnancy failure group (16 cases) according to the different pregnancy outcomes.Another 36 normal pregnant women who underwent routine check-ups in Maternity and Child Health Family Planning Service Center in Yingde City,Guangdong Province during the same period were selected as the control group.During enrollment,participants in the three groups were collected 5 mL fasting venous blood for measuring the serum E2,β-HCG and P levels.The serum E2,β-HCG and P levels of the three groups of pregnant women were compared.The positive rate of early threatened abortion predicted by the serum E2,β-HCG and P levels alone or in combination as well as its value was compared and analyzed among the three groups.Results The levels of E2,β-HCG and P in the pregnancy failure group were lower than those in the continued pregnancy group and the control group,the levels of E2,β-HCG and P in the continued pregnancy group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The diagnostic positive rates of E2,β-HCG and P alone and in combination in the pregnancy failure group and continued pregnancy group were higher than that of the control group,and thedifferences were statistically significant (P＜0.05).The diagnostic positive rate of E2,β-HCG and P alone and in combination in the pregnancy failure group was higher than that in the continued pregnancy group,and the difference was statistically significant (P＜0.05).The sensitivity (93.24%) and specificity (89.10%) in combined diagnosis of E2,β-HCG and P for early threatened abortion prediction were higher than those in single diagnosis,and the differences were statistically significant (P＜0.05).Conclusion E2,β-HCG and P are all effective indicators for judging early threatened abortion and predicting pregnancy outcomes.Combined diagnosis can increase the diagnostic accordance rate and can be used as an effective indicator for predicting the occurrence of early threatened abortion and pregnancy outcome.

Key words： Early threatened abortion Estradiol &beta -chorionic gonadotropin Progesterone

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