Cysc、mAlb/Cr及Ⅳ-C检测在2型糖尿病肾病诊断中的价值

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Abstract ObjectiveTo investigate the value of the serum cystatin (Cysc),urinary albumin/creatinine (mAlb/Cr)and typeⅣ collagen (Ⅳ-C)in the early diagnosis of type 2 diabetic nephropathy.MethodsFrom January 2016 to January 2017,60 patients with type 2 diabetes mellitus in our hospital were selected and divided into the observation group A(microalbuminuria)and the observation group B (large proteinuria)according to the different urine protein,30 cases in each group.At the same time,30 healthy volunteers in outpatient department of our hospital were randomly selected as the control group.The level of serum Cysc was determined by enhanced turbidimetry,the mAlb value of urine was determined by immune scattering method,the urinary Cr was determined by alkaline picric acid method,theⅣ-C value was determined by ELISA method.The detection rates of Cysc,mAlb/Cr and IV-C of combined determination and single determination were recorded,The sensitivity,specificity,false positive rate and false negative rate of Cysc,mAlb/Cr andⅣ-C of combined determination and single determination were compared.ResultsThe level of Cysc,mAlb/Cr andⅣ-C of the observation group A and group B increased significantly compared with the control group,while the level of Cysc,mAlb/Cr andⅣ-C of the observation group B increased significantly compared with the observation group A (P＜0.05).Combined with the single determination,the sensitivity and specificity in the combined determination significantly increased (P＜0.05).Compared with the single index measurement,the false positive rate and the false negative rate of combined determination was significantly lower (P＜0.05).ConclusionCompared with the single determination of the three indicators,the clinical application of combined determination of Cysc,mAlb/Cr andⅣ-C index in the early diagnosis of type 2 diabetic nephropathy were significantly improved,and the accuracy and specificity were higher,with clinical application and promotion significance.

Key words： Serum cystatin Urinary microalbuminuria Creatinine

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LAI Xin. Value of Cysc,mAlb/Cr andⅣ-C detection in the diagnosis of type 2 diabetic nephropathy[J]. 中国当代医药, 2017, 24(30): 136-138.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I30/136

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