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| Experimental study on the effect of Silybin on skin quality of nude mice |
| WANG Xue1 FU Wei2 YANG Liu1 LI Jian-min1▲ XU Yan-ming1▲ |
1.Experimental Center,Jiamusi College of Heilongjiang University of Traditional Chinese Medicine,Jiamusi 150047,China;
2.Department of Medicine,Cancer Hospital of Jiamusi City in Heilongjiang Province,Jiamusi154007,China |
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Abstract ObjectiveTo study the influence of Silybin cream on skin damage of nude mice model induced by UVB,including skin moisture,pH value,melanin and heme.Methods40 nude mice were divided into 4 group,they were the blank group,the model group,the positive control group and the Silybin group.The blank group was given a touch every day,and the model group was given UVB exposure every day after touching.Nude mice′s back in the positive control group and the Silybin group was smeared by Shiseido yurao zhenlai and Silybin cream before irradiated by UVB,nude mice in the model group,the positive control group and the silybin group were irradiated by UVB for 15 days continually,each time 20 min,the back of nude mice was damaged,the back was tested by the skin tester produced by German CK company after irradiating.ResultsThe moisture content in the model group decreased distinctively compared with the blank group,pH value increased,melanin and heme content increased,with significant difference(P＜0.05).The moisture content in the positive control group and the Silybin group increased compared with the blank group and the model group,pH value decreased,melanin and heme content decreased,with significant difference(P＜0.05).ConclusionSilybin can increase skin moisture,decrease hyper pigmentation,reduce skin damaged by outside stimulus,and repair damaged skin effectively.
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