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| Pathogenic characteristics of children with lower respiratory tract infection in our hospital |
| LI Zi-qiang1 LIU Xiao-yue2 Huang Yi-shuang1 LANG Xin-ling1 LIU Xi1 HUANG Wei-dong3 |
1.Department of Pediatrics,Shenzhen Bao′an District Maternal and Child Health Hospital,Guangdong Province,Shenzhen 518000,China;
2.Department of Laboratory,Shenzhen Bao′an District Maternal and Child Health Hospital,Guangdong Province,Shenzhen 518000,China;
3.Department of Pediatric Respiratory Medicine,Shenzhen Bao′an District Maternal and Child Health Hospital,Guangdong Province,Shenzhen 518000,China |
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Abstract Objective To study the etiological characteristics of children with lower respiratory infection (LRI)in our hospital.Methods A total of 435 children with clinical diagnosis of LRI from September 2016 to September 2018 were selected in our study.Childrens were examined and treated with Olympus BF-XP260 bronchoscopy(2.8 mm/4.0 mm).Bacteria in the sputum were separated,identified and tested by Bd PhoenixTMM50 automatic microbial identification and drug sensitivity analysis system.Results At least one pathogen was detected in 113 out of 435 patients and the overall positive rate was 25.98%.A total of 421 strains were obtained,among which 331 strains were gram-negative strains(78.62%),90 strains were gram-positive strains (21.38%).Gram-negative pathogens were insensitive to most antibiotics,especially to ampicillin.Among gram-positive pathogens,Staphylococcus aureus(MRSA)was sensitive to vancomycin and insensitive to other antibiotics;Streptococcus pneumoniae was insensitive to erythromycin and sensitive to other antibiotics.The detection rates of MRSA,multi-drug resistant pseudomonas (MDR-PA),multidrug-resistant acinetobacter baamannii(MDR-AB),extended-spectrum lactamasa klebsiella peeumoniac(ESBLs)(Klebsiella pneumoniae and Escherichia coli)were 52.46%,32.53%,34.72%,35.29%and 32.26%respectively.The effective rate of subbronchial therapy was 100% (98/98).Conclusion Gram-negative bacteria is more common during these two years in our hospital.Bacterias were insensitive to most antibiotics.It is effective to treat children with LRI by clinical infusion of Ambroxol Hydrochloride under bronchoscope.
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