中西医结合促肝脏细胞再生治疗肝硬化的效果分析

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Abstract Objective To explore the effect of promoting liver cell regeneration by integrated traditional Chinese and western medicine in the treatment of liver cirrhosis.Methods A total of 224 patients with decompensated cirrhosis from June 2013 to October 2016 were selected as the study subjects.They were divided into experimental group and control group according to random number table method,112 cases in each group.The patients in the control group were given routine treatment,while those in the experimental group were given integrated traditional Chinese and western medicine to promote liver cell regeneration.The clinical therapeutic effect and drug safety were compared and analyzed.The indexes of liver function and serum hepatic fibrosis were compared between the two groups.Results The total effective rate was 90.18%in the experimental group,which was significantly higher than 80.36%in the control group (P＜0.05).After treatment,the level of alpha-fetoprotein(AFP)in the experimental group was(17.00±2.31)U/ml,which was significantly lower than that in the control group([27.0±2.34]U/ml)(P＜0.05);the level of aspartate amino transferase(AST)was(43.62±7.69)U/L,which was significantly lower than that in the control group([86.47±12.58]U/L)(P＜0.05);the level of TBIL was(21.96±4.09)mol/L,which was significantly lower than that in the control group ([64.29±9.72]mol/L)(P＜0.05);the white ball ratio(A/G)was(0.80±0.37),significantly higher than that of the control group(0.60±0.21)(P＜0.05).After treatment,hyaluronic acid(HA)level in the experimental group was(300.53±107.53)μg/L,significantly lower than that in the control group([537.19±128.46]μg/L)(P＜0.05);laminin(LN)level was(96.33±26.17)μg/L,significantly lower than that in the control group([128.74±30.51]μg/L)(P＜0.05);Ⅲ procollagen(PCⅢ)level was(142.63±31.05)μg/L,significantly lower than that in the control group([167.49±40.11]μg/L)(P＜0.05).There was no significant difference in the incidence of side effects between the two groups after treatment(P＞0.05),and the side effects disappeared after symptomatic treatment.Conclusion The combination of traditional Chinese and western medicine in promoting liver cell regeneration in the treatment of liver cirrhosis has significant clinical effect,significantly reduces the biochemical indicators of patients,and the incidence of side effects is low,so it has high application clinical value.

Key words： Liver cirrhosis Activating blood circulation to dissipate blood stasis Liver cell regeneration Combination of TCM and western medicine

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	Articles by authors
	CUI Shu-wang
	SUN Zhan-hai
	DONG Ya-juan
	LIU Hai-tao
	SUN Zhong-xing

Cite this article:

CUI Shu-wang,SUN Zhan-hai,DONG Ya-juan, et al. Effect analysis of promoting hepatocyte regeneration by integrated traditional Chinese and western medicine in the treatment of liver cirrhosis[J]. 中国当代医药, 2019, 26(17): 169-171转175.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I17/169

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