复方氟米松对进展期寻常型银屑病患者Th17细胞相关细胞因子表达的影响

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Abstract Objective To investigate the effect of Compound Flumetasone in the treatment of psoriasis on the expression of helper T (Th17)cell associated cytokines.Methods A total of 52 patients with psoriasis who were admitted to the Dermatology Clinic of the Fifth Affiliated Hospital of Guangzhou Medical University from January 2016 to June 2018 were selected as the research group,and 52 healthy people who underwent the physical examination were randomly selected as the control group.The venous blood of the research group was collected before treatment(T1),1 week after treatment(T2),and 4 weeks after treatment(T3),and the venous blood collection time of the control group was the time of the physical examination(T4).The serum levels of interleukin-17A(IL-17A),interleukin-17F(IL-17F),interleukin-17E/25(IL-17E/-25),interleukin-6(IL-6)and tumor necrosis factor-α (TNF-α)were detected.The treatment effect of patients in the research group was evaluated according to the psoriasis area and severity index (PASI)score.Results The serum levels of Th17 cell associated cytokines at T3in the research group were lower than those at T2and T1,T2was lower than T1,and the differences were statistically significant(P＜0.05).The serum levels of Th17 cell associated cytokines at T1and T2in the research group were higher than those in the control group,and the differences were statistically significant(P＜0.05).There were no significant differences in serum levels of Th17 cell associated cytokines between the research group at T3and the control group (P＞0.05).The total effective rate of treatment at T2in the research group was 76.92%,and the total effective rate of treatment at T3in the research group was 92.31%.The total effective rate of treatment at T3in the research group was higher than that at T2,and the difference was statistically significant(P＜0.05).Conclusion Compound Flumetasone has a good therapeutic effect on patients with advanced vulgaris psoriasis,it can significantly reduce the PASI score and the expression of Th17 cell associated cytokines in the body of patients,which is worthy of clinical promotion.

Key words： Psoriasis Th17 cells Cytokines Compound Flumetasone

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	Articles by authors
	HUANG Mei-xing
	ZHU Lu
	FENG Lei
	LEI Shui-sheng

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HUANG Mei-xing,ZHU Lu,FENG Lei, et al. Effect of Compound Flumetasone on the expression of Th17 cell associated cytokines in patients with advanced vulgaris psoriasis[J]. 中国当代医药, 2019, 26(17): 9-11转25.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I17/9

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