腹腔镜射频消融与腹腔镜肝切除治疗慢性乙型肝炎相关特殊部位原发性肝癌的临床效果比较

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Abstract Objective To evaluate the effect and safety of laparoscopic radiofrequency ablation (LRFA) and laparoscopic hepatectomy (LH) in the treatment of chronic hepatitis B virus related special location primary liver cancer. Methods A retrospective analysis of 97 patients with chronic hepatitis B-related special site HCC patients admitted to the Affiliated Hospital of Guangdong Medical University from January 2012 to December 2017 was made，a total of 116 nodules. According to different treatment methods，they were divided into two groups. LRFA group (45 cases) received LRFA treatment，LH group (52 cases) received LH method，and were followed up for 2 years after surgery. The overall survival rate，postoperativ，liver function changes，hospital stay and incidence of complications were compared between two groups. Results The complete ablation rate of tumors in the LRFA group was 100%. The 1- and 2-year overall survival rates in the LRFA group were 90.7% and 84.0%，and those in the LH group were 91.4% and 82.5%. There was no significant difference between the two groups (P＞0.05). The level of alanine aminotransferase after LRFA was lower than that of LH group，the difference was statistically significant (P＜0.05). The hospital stay in the LRFA group was shorter than that in the LH group，and the difference was statistically significant (P＜0.05). The incidence of complications between the two groups was not statistically significant (P＞0.05).Conclusion For chronic hepatitis B virus related special location small primary liver cancer，both LRFA and LH are effective. However，LRFA not only has less liver function damage and fewer complications，but also broadens the scope of application of radiofrequency ablation，which is more advantageous for treating special location liver cancer.

Key words： Chronic hepatitis B Primary liver cancer Laparoscopic surgery Liver resection Radiofrequency ablation Overall survival rate

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	Articles by authors
	DAI Wei
	MO Cong
	SHA Rong-gui
	DAI Jia-liang
	CAI Guan-he
	MIAO Hui-lai
	BAO Shi-ting
	CHEN Ming
	TAN Xiao-yu
	LI Ming-yi
	CHEN Nian-ping

Cite this article:

DAI Wei,MO Cong,SHA Rong-gui, et al. Clinical effect comparison of laparoscopic radiofrequency ablation and laparoscopic hepatectomy in the treatment of chronic hepatitis B virus related special location small primary liver cancer[J]. 中国当代医药, 2020, 27(18): 42-45.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I18/42

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