二甲双胍联合克罗米芬治疗多囊卵巢综合征的效果观察

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Abstract ObjectiveTo investigate the therapeutic effect of Metformin combined with Clomiphene on polycystic ovary syndrome.Methods116 patients with polycystic ovarian syndrome treated in our hospital from March 2015 to January 2017 were selected as objects and were randomly divided into the observation group and the control group,58 in each group.The control group was given Clomiphene treatment,observation group on the basis of the combination of Metformin.The two groups of patients with hormone,degree of change,endometrial thickness level of ovulation rate and pregnancy rate and the incidence of adverse drug reactions were compared.ResultsAfter 3 courses of treatment,in the observation group,the changes of FINS,T,FSH,LH,endometrial thickness were better than those in the control group,the differences were statistically significant (P＜0.05).The observation group ovulation rate (72.41%),the pregnancy rate(39.66%)were higher than those of the control group,the differences were statistically significant(P＜0.05).The observation group occurred in 9 cases of adverse drug reactions,while in the control group of 7 cases,the difference was not statistically significant(P＞0.05).ConclusionThe combination of Metformin and Clomiphene on polycystic ovarian syndrome comprehensive clinical effect is good,can improve the ovulation rate and pregnancy rate,safe and effective,worthy of further clinical application.

Key words： Metformin Clomiphene Polycystic ovarian syndrome Clinical effect

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	HE Jie
	SHU Ru-ming▲

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HE Jie,SHU Ru-ming▲. Effect observation of Metformin combined with Clomiphene in treatment of polycystic ovarian syndrome[J]. 中国当代医药, 2017, 24(30): 92-94.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I30/92

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