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| Risk factors and correlation of type 2 diabetes mellitus complicated with hyperuricemia |
| WANG Dan TIAN Yu GU Xiao-lan |
| Department of Endocrinology, Dalian Municipal Central hospital Affilliated of Dalian Medical University, Liaoning Province, Dalian 116033, China |
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Abstract Objective To investigate the risk factors and correlation of type 2 diabetes mellitus (T2DM) complicated with hyperuricemia. Methods A total of 40 cases with T2DM complicated with hyperuricemia from July 2017 to October 2019 in our endocrinology department were selected as the hyperuricemia group, while 40 cases of T2DM patients without hyperuricemia at the corresponding period were selected as the normal uric acid group. The related data in the two groups were analyzed. Multivariate Logistic regression was used to analyze the independent risk factors of T2DM complicated with hyperuricemia, and the correlation between the prevalence rate of T2DM complicated with hyperuricemia and the independent risk factors was analyzed. Results Univariate analysis showed that the proportion of the age ＞50 years old, the course of disease ＞5 years, smoking history, drinking history and T2DM family history, and the incidence rates of diabetic foot, diabetic nephropathy, diabetic peripheral neuropathy, hyperlipidemia in the hyperuricemia group were higher than those of the normal uric acid group, the differences were statistically significant (P＜0.05). There was no significant difference in gender between the two groups (P＞0.05). Multivariate Logistic regression analysis showed that the influencing factors of T2DM complicated with hyperuricemia included smoking history (β=1.83, OR=1.96, 95%CI=1.03-7.45), drinking history (β=2.92, OR=6.86, 95%CI=1.59-9.24), diabetic foot (β=2.34, OR=2.81, 95%CI=1.21-4.40), diabetic nephropathy (β=0.89, OR=2.44,95%CI=1.38-4.31) and diabetic peripheral neuropathy (β=1.71, OR=5.52, 95%CI=3.10-9.83) were independent risk factors for T2DM complicated with hyperuricemia (P＜0.05). The prevalence of T2DM complicated with hyperuricemia were positively correlated with smoking time, drinking time, diabetic foot course, diabetic nephropathy course and diabetic peripheral neuropathy (r=0.893, 0.839, 0.718,0.925, 0.623, 0.541, P＜0.05). Conclusion For T2DM patients with smoking, drinking, diabetic foot, diabetic nephropathy, diabetic peripheral neuropathy, the possibility of hyperuricemia should be alerted.
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