小剂量甲强龙联合阿奇霉素治疗儿童难治性肺炎支原体肺炎的效果

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (33 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the effect and safety of low dose Methylprednisolone combined with Azithromycin in the treatment of refractory Mycoplasma pneumoniae pneumonia （RMPP） in children. Methods A total of 84 children with RMPP treated in our hospital from December 2014 to August 2018 were selected as the study subjects.According to the random number table method, the children were divided into observation group （n=43） and control group （n=41）.The children in the two groups were given expectoration, oxygen inhalation, maintenance of water electrolyte and acid-base balance.Azithromycin was given intravenously in the control group, and low dose Methylprednisolone was given in the observation group on the basis of the control group for 7 d.The time of hospitalization, the recovery time of body temperature, the level of C-reactive protein （CRP） before and after treatment and effect in the two groups were compared. Results The time of hospitalization and recovery of body temperature in the observation group were shorter than those in the control group, and the differences were statistically significant （P＜0.05）.There was no significant difference in CRP level between two groups before treatment （P＞0.05）; the CRP level in the observation group was lower than that in the control group after one week of treatment, and the difference was statistically significant （P＜0.05）.The total effective rate in the observation group was 93.0% （40/43）, which was higher than 75.6% （31/41） in the control group （χ2=4.87, P＜0.05）.In the observation group, there was one case of facial flushand and two cases of mild euphoria, but no obvious adverse reactions were observed.In the control group, there was no significant facial flush and euphoria, and the difference between the two groups was not statistically significant （χ2=2.97, P＞0.05）. Conclusion Lowdose Methylprednisolone combined with Azithromycin in the treatment of children with RMPP can effectively shorten the recovery time of body temperature and improve the effect without obvious adverse reactions.Therefore, it is recommended to use in children with RMPP.

Key words： Methylprednisolone Azithromycin Refractory Mycoplasma pneumoniae pneumonia Effect Safety

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHOU Ming-jian
	YE Sheng
	ZHENG Tao
	CHEN Xiang-jian

Cite this article:

ZHOU Ming-jian,YE Sheng,ZHENG Tao, et al. Effect of low dose Methylprednisolone combined with Azithromycin in the treatment of refractory Mycoplasma pneumoniae pneumonia in children[J]. 中国当代医药, 2020, 27(15): 150-152.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I15/150

[3]	Di Marco E.Real-time PCR detection of Mycoplasma pneumoniae in the diagnosis of community-acquired pneumonia[J].Methods Mol Biol，2014，1160：99-105.
[4]	Wang M，Wang Y，Yan Y，et al.Clinical and laboratory profiles of refractory Mycoplasma pneumoniae pneumonia in children[J].Int JInfect Dis，2014，29：18-23.
[5]	Luo Z，Luo J，Liu E，et al，Effects of prednisolone on refractory mycoplasma pneumoniae pneumonia in children[J].Pediatr Pulmonol，2014，49（4）：377-380.
[1]	Jain S，Williams DJ，Amold SR，et al.Community-acquired pneumonia requiring hospitalization among U.S.children[J].N Engl J Med，2015，372（9）：835-845.
[2]	Liu WK，Liu Q，Chen de H，et al.Epidemiology of acute respiratory infections in children in Guangzhou：a three-year study[J].PLoS One，2014，9（5）：e96674.
[6]	中华人民共和国国家健康委员会，国家中医药局.儿童社区获得性肺炎诊疗规范（2019年版）[J].中华临床感染病杂志，2019，12（1）：6-13.
[7]	咸阳，王铁岩，郑纯凤.琥珀酸钠甲泼尼龙联合纤维支气管镜术治疗难治性肺炎支原体肺炎的疗效观察[J].河北医药，2016，38（20）：3072-3075.
[8]	刘金荣，赵顺英.难治性肺炎支原体肺炎的发病机制[J].临床儿科杂志，2013，31（12）：1186-1188.
[9]	侯安存，卢炎，沙莉，等.支原体肺炎患儿辅助性T 淋巴细胞亚群Th1、Th2 细胞状况[J].中华儿科杂志，2003，41（9）：252.
[10]	Davidson MG，Coutts J，Bell G.Flexible bronchoscopy in pe diatric intensive care[J].Pediatr Pulmonol，2008，43（12）：1188-1192.
[11]	Efrati O，Sadeh-Gornik U，Modan-Moses D，et al.Flexible bronchoscopy and bronchoalveolar lavage in pediatric patients with lung disease[J].Pediatr Crit Care Med，2009，10（1）：80-84.
[12]	Laguna P，Gole biowska-Staroszczyk S，Trzaska M，et al.Immunoglobulins and their use in children[J].Adv Clin Exp Med，2015，24（1）：153-159.
[13]	Tagina T，Matsui H，Fushimi K，et al.Intravenous immunoglobulin and mortality in pneumonia patients with septic shock：an observational nationwide study[J].Clin Infect Dis，2015，61（3）：385-392.
[14]	高春燕，贺金娥，屈晖，等，甲泼尼龙辅助治疗儿童难治性支原体肺炎60 例疗效分析[J].陕西医学杂志，2014，43（1）：94-95.
[15]	吴跃进，孙节，张建华，等.糖皮质激素辅助治疗儿童肺炎支原体大叶性肺炎的疗效[J].中国当代儿科杂志，2014，16（4）：401-405.