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| Effect of regular micro-pumped urokinase as a thrombolytic therapy on maintenance hemodialysis patients |
| ZHANG Min-qiu CHENG Jing▲ |
| Department of Hemodialysis,the First Affiliated Hospital of Nanchang University,Jiangxi Province,Nanchang 330006,China |
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Abstract ObjectiveTo investigate the effect of regular micro-pumped urokinase as a thrombolytic therapy on maintenance hemodialysis(MHD)patients.MethodsFrom December 2015 to March 2017,36 MHD patients who were indwelled with dual-lumen catheter with a Dacron cuff for over 3 months in hemodialysis center in our hospital were selected.By random lot-drawing,they were evenly divided into observation group(micro-pumped urokinase as a thrombolytic therapy)and control group (retained urokinase at regular time as a thrombolytic therapy),18 cases in each group In the observation group,micro-pumped urokinase(125 000 U each time)and NS(100 ml)for one continuous hour of dripping,once every two weeks,while in the control group,urokinase(125 000 U each time)and NS(12 ml)were injected into a sealed tube for thrombolytic treatment at three times,one hour once,and once every two weeks.The courses of treatment lasted for 3 months.The blood flow volume,and the changes of venous pressure and KT/V before and after therapy were observed and compared in the two groups.The cuff tube thrombosis,tube infection,and catheter dysfunction were recorded in both groups.ResultsAfter therapy,the venous pressure in the observation group was(68.0±30.5)mmHg,much lower than that in the control group [(162.0±37.5)mmHg],with a statistical difference (P＜0.05).The blood flow volume and value of KT/V in the observation group were both superior to those in the control group with statistical differences(P＜0.05).After therapy,the cuff tube thrombosis,tube infection,and obstruction of catheter sucking were all lower than those in the control group with statistical differences(P＜0.05).The incidence of hemorrhage was not displayed significance difference after therapy(P＞0.05).ConclusionRegular micro-pumped urokinase as a thrombolytic therapy can effectively maintain the function of cuff catheter,prolong the use of catheter,and improve the efficiency of dialysis,which is a safe and effective therapeutic mode.
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