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| Clinical application effect comparison of hysteroscopy combined with Dydrogesterone or Mirena in the treatment of perimenopausal abnormal uterine bleeding |
| SONG Yun-jing HUANG Jun |
| Department of Gynecology, Ganzhou People′s Hospital, Jiangxi Province, Ganzhou 341000, China |
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Abstract Objective To explore the clinical application effect of hysteroscopy combined with Dydrogesterone or Mirena in the treatment of perimenopausal abnormal uterine bleeding. Methods A total of 102 patients with perimenopausal abnormal uterine bleeding who were treated in our hospital from January 2016 to June 2018 were selected as study subjects, and they were divided into Mirena group and Dydrogesterone group according to the random number table method, with 51 cases in each group.Dydrogesterone group was given hysteroscopy combined with Dydrogesterone while Mirena group was given hysteroscopy combined with Mirena.The disease-related indexes (endometrial thickness,hemoglobin concentration, pictorial blood loss assessment chart [PBAC]score) before and after treatment and incidence rate of adverse reactions during treatment were compared between the two groups, and the long-term efficacy after 1 year of follow-up was recorded in the two groups. Results Before treatment, there were no significant differences in the endometrial thickness, hemoglobin concentration and PBAC score between the two groups (P＞0.05).After 3 months of treatment, the endometrial thickness and PBAC score in the two groups were lower than those before treatment, the difference was statistically significant (P＜0.05), and the endometrial thickness and PBAC score in the Mirena group were lower than those in Dydrogesterone group, the differences were statistically significant (P＜0.05).After 3 months of treatment, the hemoglobin concentrations in the two groups were higher than those before treatment, the differences were statistically significant (P＜0.05), and the hemoglobin concentration in the Mirena group was high than that in Dydrogesterone group, the difference was statistically significant (P＜0.05).The incidence rate of vaginal spotting bleeding in Mirena group was 15.7%, which was higher than that in Dydrogesterone group (2.0%), the difference was statistically significant (P＜0.05), and there were no statistically significant differences in the incidence rates of other adverse reactions and the total incidence (P＞0.05).After 1 year of follow-up, the clinical efficacy of the Mirena group was better than that of the Diquprogesterone group, and the total effective rate of the Mirena group was higher than that of the Diquprogesterone group, with statistically significant differences (P＜0.05).Conclusion Hysteroscopy combined with Mirena is better than Dydrogesterone in the treatment of menopausal dysfunctional uterine bleeding, and it is prone to vaginal spotting bleeding symptoms
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