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| Clinical effect of different doses of Budesonide combined with Ipratropium Bromide Inhalation on elderly patients with AECOPD |
| LI Li1 JIANG Lan2 |
1.Department of Pharmacy,the Fifth People′s Hospital of Jingdezhen City,Jiangxi Province,Jingdezhen 333000,China;
2.Department of Respiratory,the Fifth People′s Hospital of Jingdezhen City,Jiangxi Province,Jingdezhen 333000,China |
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Abstract ObjectiveTo observe the clinical effect of different doses of Budesonide combined with Ipratropium Bromide Inhalation on Elderly patients with AECOPD and the influence on Pulmonary function and arterial blood gas.Methods88 patients with AECOPD from January 2016 to January 2017 were enrolled in this study,which were randomly divided into 44 cases of the observation group and 44 cases of the control group according to the order of the random.The control group were given low dose of Budesonide combined with Ipratropium bromide Inhalation,the observation group were treated with high dose of Budesonide combined with ipratropium bromide Inhalation,both groups had been treated for 7 days.the remission time of symptoms and signs of both group were recorded.The levels of arterial blood gas(PaO2,PaCO2)and pulmonary function (FEV1%predicted,FEV1/FVC)were measured before and 7 days after treatment.After the end of treatment，the clinical efficacy were evaluated,the occurrence of adverse reactions were observed.ResultsThe remission time of symptoms(Wheezing,shortness of breath,coughing)and signs(wheeze,wet rales)in the observation group were significantly shorter than those in the control group,the difference was statistically significant(P＜0.05).ThePaO2,FEV1% predicted value,FEV1/FVC of both group after treatment were significantly higher than before treatment(P＜0.05),the PaCO2was significantly lower than before treatment(P＜0.05),，and The PaO2,FEV1%predicted value,FEV1/FVC of the observation group after treatment were significantly higher than those in the control group(P＜0.05),the PaCO2was significantly lower than that in the control group(P＜0.05).The total effective rate of the observation group was significantly higher than the control group,the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P＞0.05).ConclusionHigh doses of budesonide combined with ipratropium bromide inhalation can improve the lung function and arterial blood gas in the treatment of elderly patients with AECOPD,and shorten the time of symptom and symptom relief,improve the clinical treatment effect,but not increase the adverse reaction rate.
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