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| Effect of nebulized inhalation and intravenous Penehyclidine on preoperative lavage of side lung in patients with large volume lung lavage |
| WEI Yun-hai |
| Department of Anesthesiology, Guangxi Zhuang Autonomous Region Workers′ Hospital, Nanning 530722, China |
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Abstract Objective To investigate the effect of nebulized inhalation and intravenous Penehyclidine on preoperative lavage of side lung in patients with large volume lung lavage.Methods A total of 109 patients who needed to be treated with large volume lung lavage admitted to the First and Second ward of pneumoconiosis in our hospital from January 2018 to June 2019 were selected as the study objects, the patients were divided into the experimental group (50 cases)and the control group (59 cases) according to the order of treatment.The experimental group was given nebulized inhalation of Penehyclidine, and the control group was given intravenous injection of Penehyclidine.The peak airway pressure and pulmonary compliance of the two groups were observed at 30 min (T1), 60 min (T2) and 90 min (T3) after lavage.The pulmonary function (FVC, FEV1, PEF) and arterial blood gas (PaO2, PaCO2) of the two groups were compared before and after operation.Results The peak airway pressures at T2 and T3 in the two groups were lower than those at T1, the pulmonary compliance at T2 and T3 in the two groups were higher than those at T1, the differences were statistically significant (P＜0.05).The peak airway pressure at T2 and T3 in the experimental group was lower than that in the control group, the difference was statistically significant (P＜0.05).The pulmonary compliance of the experimental group at T2 and T3 was higher than that of the control group, the difference was statistically significant (P＜0.05).The level of PEF, FVC, FEV1 in the experimental group after operation were higher than those in the control group, the differences were statistically significant (P＜0.05).The level of PaO2 in the experimental group after operation was significantly higher than that in the control group, and the level of PaCO2 in the experimental group after operation was significantly lower than that in the control group, the difference was statistically significant (P＜0.05).Conclusion The clinical treatment effect of atomization inhalation or intravenous injection of Penehyclidine in the lavage side of patients with large volume lung lavage before operation is ideal, which can improve the pulmonary compliance at different time points after operation, reduce the peak airway pressure and improve the pulmonary function.
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| [1] |
朱佑明，甘易玲，夏薇.大容量全肺灌洗术对尘肺病合并慢性阻塞性肺疾病的疗效分析[J].临床和实验医学杂志，2017，16（23）：2326-2329.
|
| [2] |
李钢，陈旭.盐酸戊乙奎醚对缺血再灌注损伤大鼠海马CA1 区神经细胞及TNF-α、IL-10 表达的影响[J].中国临床研究，2018，31（1）：51-55.
|
| [3] |
张龙，许伟，黄崇健.沙丁胺醇与噻托溴铵联合治疗对慢性阻塞性肺疾病急性加重期患者肺功能和呼吸动力学的影响[J].宁夏医科大学学报，2018，40（1）：37-41.
|
| [4] |
毛洁，窦红，彭伊.大容量全肺灌洗术中持续心电监护对手术安全性评估的意义[J].中国医学创新，2018，15（13）：136-139.
|
| [5] |
闫书梅，孙玉香，肖新宇.大容量肺灌洗术中精确调节肺通气量的影响[J].职业与健康，2018，34（15）：2035-2038.
|
| [6] |
索南吉.支气管肺泡灌洗技术对急性呼吸衰竭患者肺功能、呼吸动力学及氧代谢的影响[J].宁夏医科大学学报，2018，40（5）：562-565.
|
| [7] |
田峰利.汉防己甲素片联合大容量全肺灌洗术治疗尘肺的临床效果[J].智慧健康，2017，3（1）：21-23.
|
| [8] |
李德鸿.尘肺病诊断标准GBZ70-2009[C]//2010 尘肺病影像诊断新进展研讨会论文集[A].中国疾病预防控制中心职业卫生与中毒控制所，2010：12-26.
|
| [9] |
段晶，陈燕，邵勇平.麻醉前使用盐酸戊乙奎醚对腰硬联合麻醉腹部手术患者血液动力学及牵拉反应的影响研究[J].河北医药，2017，39（4）：567-569，572.
|
| [10] |
刘荣，李洁.清肺消炎汤联合纤维支气管镜灌洗术治疗重症肺炎（痰热壅肺证）的临床观察[J].中国中医急症，2019，28（4）：688-690.
|
| [11] |
张永贵，何丁秀，黄天堃.盐酸右美托咪定对大容量全肺灌洗术患者血流动力学的影响及肺保护作用[J].中外医学研究，2017，15（25）：32-34.
|
| [12] |
黄建忠，张文清，黄巧文，等.肺泡蛋白沉积症行大容量单侧肺灌洗术的麻醉处理[J].福建医药杂志，2017，39（4）：143-145.
|
| [13] |
袁项英.大容量全肺灌洗术联合粉防己碱片序贯治疗对Ⅱ期尘肺患者生命质量及氧化应激的影响[J].医疗装备，2017，30（20）：139-140.
|
| [14] |
夏梦，赵维珊，雷钧，等.盐酸戊乙奎醚不同给药方式对大容量肺灌洗患者术后呼吸动力学的影响[J].国际麻醉学与复苏杂志，2017，38（8）：702-704，727.
|
| [15] |
刘羿，张守华，杜晓红，等.盐酸戊乙奎醚预处理对大鼠肝脏缺血-再灌注损伤的影响[J].临床麻醉学杂志，2016，32（7）：684-687.
|
|
|
|
