腹腔镜袖状胃切除手术治疗肥胖合并2型糖尿病患者的效果及对其胃肠激素水平的影响

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Abstract Objective To investigate the effect of laparoscopic sleeve gastrectomy (LSG) in the treatment of obesity complicated with type 2 diabetes and its effect on gastrointestinal hormone levels.Methods A total of 88 patients with obesity and type 2 diabetes treated in our hospital from January 2017 to January 2018 were selected as subjects, they were divided into control group and LSG group according to random number table method, with 44 cases in each group.Patients in the control group were given conventional hypoglycemic drugs and symptomatic treatment.The patients in the observation group were treated with LSG on the basis of the control group.The body mass index(BMI),serum glycosylated hemoglobin (HbA1c), insulin, glucagon-like polypeptide-1 (GLP-1), intestinal inhibitory peptide (GIP), and gastrin were compared between the two groups.Results After treatment, the BMI and HbA1c levels in the LSG group were lower than those in the control group, the differences were statistically significant (P<0.05).The insulin and gastrin levels in the LSG group were lower than those in the control group, and GLP-1 level was higher than that in the control group, the differences were statistically significant (P<0.05).There was no significant difference in GIP level between the two groups after treatment (P>0.05).Conclusion LSG is effective in the treatment of obesity complicated with type 2 diabetes, and significantly improves its gastrointestinal hormone levels, which is worthy of clinical application.

Key words： Sleeve gastrectomy Obesity Type 2 diabetes Gatrogen hormone

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	XU Feng
	ZHANG Qi-min
	ZHOU Xin-qi▲

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XU Feng,ZHANG Qi-min,ZHOU Xin-qi▲. Effect of laparoscopic sleeve gastrectomy in the treatment of obesity complicated with type 2 diabetes and its effect on gastrointestinal hormone levels[J]. 中国当代医药, 2020, 27(12): 74-76.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I12/74

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