丙戊酸钠负荷剂量与奥氮平治疗双相Ⅰ型躁狂发作的随机对照研究

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Abstract Objective To investigate the efficacy and safety of loading dose of Sodium Valproate combined with Olanzapine in the treatment of bipolar type Ⅰ disorder patients with manic episode.Methods Altogether 80 cases of bipolar type Ⅰ disorder patients with manic episode who were treated in our hospital from January 2015 to October 2016 were randomly divided into treatment group and control group,with 40 cases in each group.Control group was treated with olanzapine;while,treatment group was treated with the loading dose of Sodium Valproate.The therapeutic effects of the two groups were compared.Results The effective rate of treatment group were 82.50% versus control group′s 77.50%,without statistically significant difference between the two groups (P>0.05).The postoperative YMRS (Young Manic Rating Scale) and BPRS (Brief psychiatric Rating Scale) scores of treatment group were (7.4±5.3) and (8.8±3.5) score,compared with control group [(9.8±3.5),(13.5±7.4)scores],with statistically significant difference (P<0.05).The HAMD (Hamilton Rating Scale for Depression) score (4.5±1.7) of treatment group was lower than that of control group (4.7±2.7),without statistically significant difference (P>0.05).The incidence of adverse reactions of treatment group was 7.50% versus control group′s 25.00%,with statistically significant difference between the two groups (P<0.05).Conclusion The efficacy of application of the loading dose of Sodium Valproate is similar to that of Olanzapine in the treatment of bipolar type Ⅰ disorder patients with manic episode,which has less adverse reactions and is worthy of wide clinical use.

Key words： Sodium valproate Olanzapine Bipolar type Ⅰ manic episode Treatment outcome

Received: 17 May 2017

PACS:

R749.4

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	YU Hua
	WAN Jian-guo

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YU Hua,WAN Jian-guo. Randomized controlled study of loading dose of Sodium Valproate and Olanzapine in treatment of bipolar Type Ⅰ disorder patients with manic episode[J]. 中国当代医药, 2017, 24(25): 39-41.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I25/39

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