血凝四项在不同程度弥散性血管内凝血中的对比研究

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Abstract Objective Through the detection of prothrombin time (PT), activated partial prothrombin time (APTT), fibrinogen (FIB) content and thrombin time (TT) in different stages of disseminated intravascular coagulation (DIC), to discuss the relationship between the degree of DIC and the four levels of blood coagulation, and to evaluate the value of four items of blood coagulation in the clinical diagnosis of DIC.Methods From March 2018 to April 2019, 90 patients with known DIC related basic diseases were selected.According to early diagnosis, they were divided into hypercoagulable group, the lysozyme group and the fibrinolytic group, with 30 cases in each group.In addition, 30 healthy volunteers in the same period were randomly selected as the control group, and four blood coagulation levels in each group were measured, and the relationship between the four items of hemagglutination and the course of DIC was analyzed.Results PT and APTT of the hypercoagulable group, the lysozyme group and the fibrinolytic group were longer than those of the control group, and the differences were statistically significant (P＜0.05).TT of the lysozyme group and the fibrinolytic group were longer than that of the control group, and FIB was lower than that of the control group, the differences were statistically significant (P＜0.05).There was no significant difference in TT and FIB content between the hypercoagulant group and the control group (P＞0.05).The APTT of the lysozyme group was longer than that of the hypercoagulant group, and the FIB content of the lysozyme group was lower than that of the hypercoagulant group, the differences were statistically significant (P＜0.05).PT, APTT and TT in the fibrinolytic group were longer than those in the hypercoagulant group, and the content of FIB was lower than those in the hypercoagulant group, with statistically significant difference (P＜0.05).PT, APTT and TT in the fibrinolytic group were longer than those in the lysozyme group, and the content of FIB in the fibrinolytic group was lower than that in the lysozyme group, with statistically significant difference (P＜0.05).Linear correlation analysis showed that PT, APTT were positively correlated with the course of DIC (r=0.81, 0.77; P＜0.05).FIB was negatively correlated with the course of DIC (r=-0.72, P＜0.05).TT was not correlated with the course of DIC (P＞0.05).Conclusion The four indexes of hemagglutination have significant differences in different periods of DIC.The early detection and analysis of each index is helpful to the clinical diagnosis of early DIC and the prediction of the development period of DIC.

Key words： Disseminated intravascular coagulation Four items of hemagglutination Prothrombin time Activated partial prothrombin time Fibrinogen

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	JING Feng

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JING Feng. Comparative study of four items of hemagglutination in different degrees of diffuse intravascular coagulation[J]. 中国当代医药, 2020, 27(8): 162-165.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I8/162

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