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| Predictive value of combined detection of albumin, cystatin C and bilirubin in acute cerebral infarction complicated with acute kidney injury |
| CHI Rui-feng LIN Bing-wei LIN Xi-chun |
| Department of Internal Medicine, the Second People′s Hospital of Jiedong District in Jieyang City, Guangdong Province, Jieyang 515500, China |
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Abstract Objective To investigate the predictive value of combined detection of albumin (ALB), cystatin C (CysC)and bilirubin (TB) in acute cerebral infarction complicated with acute kidney injury (AKI).Methods A total of 30 patients with acute cerebral infarction and AKI admitted to our hospital from January to December 2018 were selected as the acute cerebral infarction+AKI group, 30 patients with acute cerebral infarction without AKI were selected as the acute cerebral infarction group, and another 30 healthy subjects with healthy physical examinations were selected as the controls group.The serum biochemical indicators and the national institutes of health stroke scale (NIHSS) scores were compared among each group of subjects.Logistic regression analysis was performed on the indicators with differences,and the receiver operating characteristic (ROC) curve was used to evaluate the predictive value of the indicators.Results The levels of ALB, CysC, and high-sensitivity C-reactive protein (hs-CRP) in the acute cerebral infarction+AKI group were higher than those in the acute cerebral infarction group and control group, the TB level was lower than that in the acute cerebral infarction group and control group, the NIHSS score in the acute cerebral infarction+AKI group was higher than that in the acute cerebral infarction group, and the differences were statistically significant (P＜0.05).Multivariate Logistic regression analysis showed that ALB, CysC, and TB were risk factors for acute cerebral infarction with AKI (P＜0.05).ROC curve analysis showed that the area under the curve (AUC) of the combined detection of ALB,CysC, and TB was larger than that of ALB, CysC, and TB detection alone, and the differences were statistically significant (P＜0.05).Conclusion ALB, CysC and TB have high predictive value for acute cerebral infarction complicated with AKI, and combined detection can improve prediction sensitivity and specificity.
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| [1] |
孙文斌，梁宗敏.帕瑞昔布钠对急性脑梗死患者疗效、炎症指标及肾功能的影响[J].广西医学，2016，38（11）：1557-1559.
|
| [2] |
王欣，徐玲玲，贾俐聪.急性脑梗死合并急性肾梗死一例[J].中华老年心脑血管病杂志，2016，18（12）：1323-1324.
|
| [3] |
陈后勤，吕秋石，何敏，等.急性腔隙性脑梗死患者慢性肾功能不全与脑微出血的相关性研究[J].医学研究生学报，2017，30（3）：294-297.
|
| [4] |
陈兴东，罗伟良.成人房颤急性脑梗死与非房颤急性脑梗死住院患者肾功能不全的对照分析[J].实用医学杂志，2017，33（7）：1040-1043.
|
| [5] |
江艳柳，王书培，张玉琴.缺血适应对急性脑梗死患者NIHSS评分及血清CysC 水平的影响及相关性[J].中国老年学杂志，2016，36（4）：849-851.
|
| [6] |
中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中华神经科杂志，2010，43（2）：146-153.
|
| [7] |
张琦，牛文彦，李晓亮，等.急性脑梗死患者血浆Hcy、eNOS、sTM、hs-CRP、vWF的变化及意义[J].山东医药，2015，55（1）：17-19.
|
| [8] |
石群.胱抑素C 与急性脑梗死患者病情严重程度及肾功能变化的关系[J].国际检验医学杂志，2015，36（14）：2077-2078，2080.
|
| [9] |
王大成，劳全坤，沈小棋，等.肾病综合征合并脑梗死临床特点及其可能机制[J].中风与神经疾病杂志，2015，32（7）：631-633.
|
| [10] |
肖伟，罗艺，陈薇，等.急性脑梗死合并早期肾损伤患者血清同型半胱氨酸和超敏C反应蛋白联合检测的临床价值[J].海南医学，2018，29（1）：68-70.
|
| [11] |
孙树敏，张力辉，罗晓晨，等.肝、肾功能及血脂指标与急性脑梗死预后的相关性研究[J].国际检验医学杂志，2018，39（10）：1215-1219.
|
| [12] |
李秋，高雅萱，陈嘉峰.肾病综合征合并脑梗死的可能病理机制、临床特点及预防[J].中风与神经疾病杂志，2018，35（6）：572-573.
|
| [13] |
孙庆利，孙阿萍，傅瑜，等.肾病综合征合并急性脑梗死患者临床及影像学特点分析[J].中国脑血管病杂志，2018，15（9）：461-465.
|
| [14] |
董恺，张倩，俞志鹏，等.肾小球滤过率与急性脑梗死患者脑血管病变及预后的相关性研究[J].中国脑血管病杂志，2016，13（8）：421-426.
|
| [15] |
郭柳彩，南光贤.老年急性脑梗死患者血清胆红素水平的变化及临床意义[J].中国老年学杂志，2016，36（10）：2383-2384.
|
| [16] |
王小永，于翔，李永强，等.巨噬细胞移动抑制因子在诊断老年肾病综合征合并脑梗死患者的临床应用[J].中国临床保健杂志，2016，19（4）：392-394.
|
| [17] |
董恺，张倩，俞志鹏，等.肾小球滤过率与急性脑梗死患者脑血管病变及预后的相关性研究[J].中国脑血管病杂志，2016，13（8）：421-426.
|
| [18] |
卢涛声，徐珍瑾，王国军，等.慢性肾功能不全对老年急性脑梗死患者远期预后的影响[J].中华老年心脑血管病杂志，2016，18（9）：934-937.
|
|
|
|
