芪苈强心胶囊调节Toll样受体治疗急性心肌缺血再灌注后患者的临床效果

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Abstract Objective To study the value of Qili Qiangxin Capsules modulating Toll-like receptors in improving cardiac function in patients after acute myocardial ischemia (MI) and reperfusion. Methods A total of 100 patients after acute MI and reperfusion treated in the Department of Cardiology in Jiangxi Provincial People′s Hospital from January 2017 to December 2018 were selected as subjects.They were divided into control group and observation group according to the random number table method,50 cases in each group.In the control group,standard therapy was used,while in the observation group,standard treatment combined with Qili Qiangxin Capsules was adopted.The cardiac function indicators like N-terminal pro brain natriuretic peptide (NT-proBNP),left ventricular ejection fraction (LVEF),left ventricular end-systolic diameter (LVESD),left ventricular end-diastolic diameter (LVEDD) and inflammatory factors such as chemokines IP-10 (IP-10),interleukin-8 (IL-8),tumor necrosis factor-α (TNF-α) were compared in the two groups.Results Before treatment,there were no significant differences in LVEF,LVESD,LVEDD,and NT-proBNP between the two groups (P＞0.05).After treatment,LVEF in both groups was higher than that before treatment,LVESD,LVEDD and NT-proBNP in both groups were lower than those before treatment,the differences were statistically significant(P＜0.05).After treatment,the LVEF of the observation group was higher than that of the control group,the LVESD,LVEDD and NT-proBNP of the observation group were lower than those of the control group,the differences were statistically significant (P＜0.05).Before treatment,there were no significant differences in IP-10,IL-8 and TNF-α between the two groups (P＞0.05).After treatment,IP-10,IL-8 and TNF-α in both groups were lower than those before treatment,the differences were statistically significant (P＜0.05).After treatment,the IP-10,IL-8 and TNF-α in the observation group were all lower than those of the control group,the differences were statistically significant (P＜0.05).Conclusion Qili Qiangxin Capsules can inhibit the expression of inflammatory factors by regulating Toll-like receptors,so as to improve the cardiac function of patients after acute MI and reperfusion,which is worthy of promotion.

Key words： Qili Qiangxin Capsules Toll-like receptor Acute myocardial ischemia and reperfusion Inflammatory factors Cardiac function

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	Articles by authors
	SHAO Liang
	ZHANG Ping
	CAI Xin-yong
	XIAO Bin
	MEI Song-bei

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SHAO Liang,ZHANG Ping,CAI Xin-yong, et al. Clinical effect of Qili Qiangxin Capsules modulating Toll-like receptors in the treatment of patients after acute myocardial ischemia and reperfusion[J]. 中国当代医药, 2020, 27(1): 4-7.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I1/4

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