电休克治疗难治性精神分裂症的效果

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Abstract [Abstract]Objective To investigate the clinical effect of electroconvulsive shock in the treatment of refractory schizophrenia.Methods The clinical data of 50 patients with refractory schizophrenia treated in our hospital from January 2017 to June 2018 were retrospectively analyzed.They were divided into the observation group(25 cases)and the control group (25 cases)according to the different treatment schemes.The patients in control group were treated with Risperidone and the patients in observation group were treated with electroconvulsive shock.The clinical treatment effect,the positive and negative symptom scales(PANSS)scores and the changes in the Wisconsin card sorting test(WCST)Results before and after treatment and the total incidence rate of adverse reactions during treatment were compared between the two groups.Results The total effective rate of the observation group was slightly higher than that of the control group,but the difference was not statistically significant(P>0.05).There were no significant differences in PANSS scores between the two groups at admission(P>0.05).The PANSS scores at 2,5,and 9 weeks after treatment in the two groups were significantly lower than those at admission,and the differences were statistically significant(P<0.05).The PANSS scores at 2,5,and 9 weeks after treatment of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the WCST between the two groups at admission(P>0.05).The total number of tests,the number of false responses and the number of persistent errors at 9 weeks after treatment in the two groups were significantly lower than those at admission,the number of completed classifications was significantly higher than that at admission,and the differences were statistically significant(P<0.05).The total number of tests,the number of false responses and the number of persistent errors at 9 weeks after treatment in the observation group were significantly lower than those in the control group,the number of completed classifications was significantly higher than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence rate of adverse reactions between the two groups during treatment(P>0.05).Conclusion The effect of electroconvulsive shock is similar to that of Risperidone in the treatment of refractory schizophrenia and both have fine safety.However,electroconvulsive shock is more effective in improving the positive and negative symptoms of patients,which is worthy of clinical recommendation.

Key words： Refractory schizophrenia Electroconvulsive shock Risperidone Efficacy Safety

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