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Abstract Objective To explore the clinical effect of Bushen Jianpi Yiqi Recipe in the treatment of stage 3 chronic kidney disease with spleen and kidney qi deficiency type.Methods One hundred patients with stage 3 chronic kidney disease of spleen and kidney qi deficiency who were admitted to Hubei Provincial Hospital of Traditional Chinese Medicine from March 2016 to December 2017 were selected as the study subjects.They were divided into control group (50 cases) and experimental group (50 cases) according to the random number table method.The patients in the control group were treated with Western medicine, and the patients in the experimental group were treated with Bushen Jianpi Yiqi Recipe on the basis of the control group.The serum creatinine (SCr), blood urea nitrogen (BUN), urea (UA),glomerular filtration rate (eGFR) and urine protein (U-Pro) index before and after treatment, the treatment effect and adverse reactions were compared between the two groups.Results There were no significant differences in SCr, BUN,UA, eGFR and U-Pro between the two groups before treatment (P＞0.05).The levels of SCr, BUN, UA and U-Pro in the experimental group after 12 weeks of treatment were lower than those before treatment, the eGFR was higher than that before treatment, and the differences were statistically significant (P＜0.01).The levels of SCr and UA in the control group after 12 weeks of treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05).There were no significant differences in BUN, eGFR and U-Pro between the control group before treatment and after 12 weeks of treatment (P＞0.05).The levels of SCr, UA and U-Pro in the experimental group after 12 weeks of treatment were lower than those in the control group, the eGFR was higher than that in the control group, and the differences were statistically significant (P＜0.05).There was no significant difference in BUN level between the two groups after 12 weeks of treatment (P＞0.05).The total effective rate of the treatment in the experimental group was 72.92%, which was significantly higher than that in the control group (46.81%), and the difference was statistically significant (P＜0.05).There were no significant adverse reactions in the two groups after the end of the treatment.Conclusion Bushen Jianpi Yiqi Recipe in the treatment of patients with stage 3 chronic kidney disease of spleen and kidney qi deficiency has good clinical effect in improving traditional Chinese medicine symptoms, reducing urine protein and protecting kidney function.

Key words： Bushen Jianpi Yiqi Recipe Stage 3 chronic kidney disease Spleen and kidney qi deficiency Randomized controlled study

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	TIAN Man
	QI Zheng-liang
	LI Jiao

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TIAN Man,QI Zheng-liang,LI Jiao. Clinical effect of Bushen Jianpi Yiqi Recipe in the treatment of stage 3 chronic kidney disease with spleen and kidney qi deficiency type[J]. 中国当代医药, 2019, 26(12): 12-15转25.

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