血清miR- 125a 表达水平在慢性阻塞性肺疾病早期诊断中的应用价值

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Abstract Objective To investigate the value of serum miR-125a as a biomarker in the early diagnosis of chronic obstructive pulmonary disease (COPD).Methods A total of 50 patients with COPD who were admitted to our hospital from January 2017 to June 2018 were selected as the COPD group.Another 50 normal people were selected as the healthy control group and 50 severe smokers were used as the severe smoking group.The peripheral serum samples and clinical basic data were collected of three groups.The expression levels of miR-125a in peripheral blood of the three groups were detected by real-time fluorescence quantitative method, the ROC curve of serum miR-125a expression was analyzed and the wound healing rate of the three groups was recorded.Results The mRNA expression level of serum miR-125a in the COPD group was significantly lower than that in the severe smoking group, the mRNA expression level of miR-125a in the severe smoking group was significantly lower than that in the healthy control group, and the differences were statistically significant (P＜0.05).The area under the ROC curve of the severe smoking group was larger than that of the COPD group, and the area under the ROC curve of the COPD group was larger than that of the healthy control group, with statistically significant differences (P＜0.05).The wound healing rate of the severe smoking group and the COPD group was lower than that of the healthy control group, and the difference was statistically significant(P＜0.05).Conclusion The expression levels of serum miR-125a decrease in patients with COPD and severe smoking,and serum miR-125a can be used as a biomarker for the early diagnosis of COPD to provide a basis for prevention.

Key words： Chronic obstructive pulmonary disease miR-125a Biomarkers Early diagnosis

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